TY - JOUR
T1 - Influence of RANTES, SDF-1 and TGF-β levels on the value of interleukin-7 as a predictor of virological response in HIV-1-infected patients receiving double boosted protease inhibitor-based therapy
AU - Boulassel, M. R.
AU - Smith, G. H.R.
AU - Edwardes, M. D.de B.
AU - Young, M.
AU - Klein, M.
AU - Gilmore, N.
AU - MacLeod, J.
AU - LeBlanc, R.
AU - René, P.
AU - Allan, J.
AU - Lalonde, R. G.
AU - Routy, Jean Pierre
PY - 2005/7
Y1 - 2005/7
N2 - Objectives: Interleukin-7 (IL-7), RANTES (regulated on activation, normal T cell expressed and secreted), stromal cell-derived factor-1 (SDF-1) and transforming growth factor-beta (TGF-β) appear to share certain biological properties in vitro and all are involved in HIV-1 disease progression. Our earlier observations indicated that IL-7 levels decrease upon CD4 T-cell recovery and represent a new, independent predictor of virological response. Here, we examine associations among circulating levels of IL-7, RANTES, SDF-1 and TGF-β in hopes of gaining insight into their contribution to the predictive value of IL-7. Methods: Levels of IL-7, RANTES, SDF-1 and TGF-β, and immune and viral parameters were assessed in HIV-1-infected patients. Results: Cross-sectional (n = 148) and longitudinal (n = 36) analyses showed that levels of IL-7, but not RANTES, SDF-1 or TGF-β, were increased in HIV-1-infected adults compared with those of healthy controls. In the cross-sectional study, levels of IL-7 were correlated with RANTES (r = 0.31, P = 0.002) and TGF-β (r= 0.53, P<0.001) but not with SDF-1 (r=0.12, P=0.22), and these associations were more pronounced in patients with CD4 T-cell counts > 200 cells/μL. In contrast to IL-7, levels of RANTES, SDF-1 and TGF-β were not correlated with CD4 T-cell counts. Longitudinal analysis revealed a marked decline in IL-7 levels accompanied by an increase in CD4 T-cell count following antiretroviral therapy (ART), but no changes in RANTES, SDF-1 or TGF-β levels. Multivariate regression analysis showed no influence of baseline RANTES, SDF-1 or TGF-β levels on the value of IL-7 as a predictor of virological response at 48 weeks. Conclusions: Collectively, these results indicate that changes in IL-7 levels did not induce changes in RANTES, SDF-1 or TGF-β. Furthermore, they indicate that RANTES, SDF-1 or TGF-β levels do not explain the predictor value of IL-7 in patients receiving ART.
AB - Objectives: Interleukin-7 (IL-7), RANTES (regulated on activation, normal T cell expressed and secreted), stromal cell-derived factor-1 (SDF-1) and transforming growth factor-beta (TGF-β) appear to share certain biological properties in vitro and all are involved in HIV-1 disease progression. Our earlier observations indicated that IL-7 levels decrease upon CD4 T-cell recovery and represent a new, independent predictor of virological response. Here, we examine associations among circulating levels of IL-7, RANTES, SDF-1 and TGF-β in hopes of gaining insight into their contribution to the predictive value of IL-7. Methods: Levels of IL-7, RANTES, SDF-1 and TGF-β, and immune and viral parameters were assessed in HIV-1-infected patients. Results: Cross-sectional (n = 148) and longitudinal (n = 36) analyses showed that levels of IL-7, but not RANTES, SDF-1 or TGF-β, were increased in HIV-1-infected adults compared with those of healthy controls. In the cross-sectional study, levels of IL-7 were correlated with RANTES (r = 0.31, P = 0.002) and TGF-β (r= 0.53, P<0.001) but not with SDF-1 (r=0.12, P=0.22), and these associations were more pronounced in patients with CD4 T-cell counts > 200 cells/μL. In contrast to IL-7, levels of RANTES, SDF-1 and TGF-β were not correlated with CD4 T-cell counts. Longitudinal analysis revealed a marked decline in IL-7 levels accompanied by an increase in CD4 T-cell count following antiretroviral therapy (ART), but no changes in RANTES, SDF-1 or TGF-β levels. Multivariate regression analysis showed no influence of baseline RANTES, SDF-1 or TGF-β levels on the value of IL-7 as a predictor of virological response at 48 weeks. Conclusions: Collectively, these results indicate that changes in IL-7 levels did not induce changes in RANTES, SDF-1 or TGF-β. Furthermore, they indicate that RANTES, SDF-1 or TGF-β levels do not explain the predictor value of IL-7 in patients receiving ART.
KW - HIV-1 infection
KW - IL-7
KW - Predictive value
KW - RANTES
KW - SDF-1
KW - TGF-β
UR - http://www.scopus.com/inward/record.url?scp=22644439372&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=22644439372&partnerID=8YFLogxK
U2 - 10.1111/j.1468-1293.2005.00306.x
DO - 10.1111/j.1468-1293.2005.00306.x
M3 - Article
C2 - 16011532
AN - SCOPUS:22644439372
SN - 1464-2662
VL - 6
SP - 268
EP - 277
JO - HIV Medicine
JF - HIV Medicine
IS - 4
ER -
