Influence of diallyl disulphide on temporal patterns of liver marker enzymes in experimental hepatocarcinogenesis in rats

Thamilarasan Manivasagam, Perumal Subramanian, Ganapathy Suthakar, Musthafa Mohamed Essa, Ramar Sivaperumal, Selvaraju Subash

Research output: Contribution to journalArticle

Abstract

The present study aims to investigate the effects of diallyl disulphide (DADS) on the temporal patterns of tumor marker enzymes, such as serum alkaline phosphatase (ALP), alanine transaminase (ALT), aspartate transaminase (AST), and γ-glutamyl transpeptidase (GGT) during N-nitrosodiethylamine (NDEA) induced hepatocarcinogenesis in rats. The acrophase of all marker enzymes was found to be delayed in NDEA-treated rats. The increased mesor, altered amplitude and acrophase of these markers indicated the index of liver damage. Oral treatment of DADS results in normalization of the altered rhythms of these tumor markers (compared with controls) by its anticarcinogenic and antiproliferative effects. Furthermore, this study indicates the necessity of detailed investigation to reveal the temporal interplay between the central biological clock (suprachiasmatic nucleus), peripheral tissue (liver) based oscillators and cancer processes.

Original languageEnglish
Pages (from-to)697-702
Number of pages6
JournalBiologia - Section Cellular and Molecular Biology
Volume60
Issue number6
Publication statusPublished - Nov 2005

Fingerprint

Diethylnitrosamine
Tumor Biomarkers
Liver
Rats
Anticarcinogenic Agents
enzyme
Biological Clocks
Suprachiasmatic Nucleus
gamma-Glutamyltransferase
Enzymes
Aspartate Aminotransferases
Alanine Transaminase
tumor
Alkaline Phosphatase
Clocks
Tissue
Serum
phosphatase
serum
cancer

Keywords

  • Circadian rhythms
  • Diallyl disulphide
  • N-nitrosodiethylamine
  • Tumor marker enzymes

ASJC Scopus subject areas

  • Environmental Science(all)
  • Genetics
  • Clinical Biochemistry
  • Cell Biology

Cite this

Influence of diallyl disulphide on temporal patterns of liver marker enzymes in experimental hepatocarcinogenesis in rats. / Manivasagam, Thamilarasan; Subramanian, Perumal; Suthakar, Ganapathy; Essa, Musthafa Mohamed; Sivaperumal, Ramar; Subash, Selvaraju.

In: Biologia - Section Cellular and Molecular Biology, Vol. 60, No. 6, 11.2005, p. 697-702.

Research output: Contribution to journalArticle

Manivasagam, Thamilarasan ; Subramanian, Perumal ; Suthakar, Ganapathy ; Essa, Musthafa Mohamed ; Sivaperumal, Ramar ; Subash, Selvaraju. / Influence of diallyl disulphide on temporal patterns of liver marker enzymes in experimental hepatocarcinogenesis in rats. In: Biologia - Section Cellular and Molecular Biology. 2005 ; Vol. 60, No. 6. pp. 697-702.
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