Influence of auto-antibody specificities on the clinical course in patients with chronic and acute ITP

Y. S. Mehta, A. V. Pathare, S. S. Badakere, K. Ghosh, Dipika Mohanty

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

It is now well established that the target antigens of platelet auto-antibodies are the GP IIb/IIIa and GP Ib/IX receptors. In our study, it was observed that the majority of patients had antibodies directed towards the GP IIb/IIIa receptor, whereas the number of patients having antibodies directed towards the GP Ib/IX receptor was much less. Also, we found that the patients in whom the auto-antibodies are directed towards the GP IIb/IIIa receptors usually have mild bleeding. On the other hand, the patients having auto-antibodies directed towards both GP IIb/IIIa and GP Ib/IX receptors have a severe bleeding diathesis, and usually show poor prognosis to treatment with corticosteroids.

Original languageEnglish
Pages (from-to)94-98
Number of pages5
JournalPlatelets
Volume11
Issue number2
Publication statusPublished - 2000

ASJC Scopus subject areas

  • Cell Biology
  • Hematology

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