Influence of auto-antibody specificities on the clinical course in patients with chronic and acute ITP

Y. S. Mehta, A. V. Pathare, S. S. Badakere, K. Ghosh, Dipika Mohanty

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

It is now well established that the target antigens of platelet auto-antibodies are the GP IIb/IIIa and GP Ib/IX receptors. In our study, it was observed that the majority of patients had antibodies directed towards the GP IIb/IIIa receptor, whereas the number of patients having antibodies directed towards the GP Ib/IX receptor was much less. Also, we found that the patients in whom the auto-antibodies are directed towards the GP IIb/IIIa receptors usually have mild bleeding. On the other hand, the patients having auto-antibodies directed towards both GP IIb/IIIa and GP Ib/IX receptors have a severe bleeding diathesis, and usually show poor prognosis to treatment with corticosteroids.

Original languageEnglish
Pages (from-to)94-98
Number of pages5
JournalPlatelets
Volume11
Issue number2
Publication statusPublished - 2000

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Inosine Triphosphate
Antibody Specificity
Platelet Membrane Glycoprotein IIb
Antibodies
Hemorrhage
Disease Susceptibility
Adrenal Cortex Hormones
Blood Platelets
Antigens

ASJC Scopus subject areas

  • Cell Biology
  • Hematology

Cite this

Influence of auto-antibody specificities on the clinical course in patients with chronic and acute ITP. / Mehta, Y. S.; Pathare, A. V.; Badakere, S. S.; Ghosh, K.; Mohanty, Dipika.

In: Platelets, Vol. 11, No. 2, 2000, p. 94-98.

Research output: Contribution to journalArticle

Mehta, YS, Pathare, AV, Badakere, SS, Ghosh, K & Mohanty, D 2000, 'Influence of auto-antibody specificities on the clinical course in patients with chronic and acute ITP', Platelets, vol. 11, no. 2, pp. 94-98.
Mehta, Y. S. ; Pathare, A. V. ; Badakere, S. S. ; Ghosh, K. ; Mohanty, Dipika. / Influence of auto-antibody specificities on the clinical course in patients with chronic and acute ITP. In: Platelets. 2000 ; Vol. 11, No. 2. pp. 94-98.
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