Influence of auto-antibody specificities on the clinical course in patients with chronic and acute ITP

Y. S. Mehta; A. V. Pathare; S. S. Badakere; K. Ghosh; Dipika Mohanty

doi:10.1080/09537100075706

Influence of auto-antibody specificities on the clinical course in patients with chronic and acute ITP

Y. S. Mehta^*, A. V. Pathare, S. S. Badakere, K. Ghosh, Dipika Mohanty

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

It is now well established that the target antigens of platelet auto-antibodies are the GP IIb/IIIa and GP Ib/IX receptors. In our study, it was observed that the majority of patients had antibodies directed towards the GP IIb/IIIa receptor, whereas the number of patients having antibodies directed towards the GP Ib/IX receptor was much less. Also, we found that the patients in whom the auto-antibodies are directed towards the GP IIb/IIIa receptors usually have mild bleeding. On the other hand, the patients having auto-antibodies directed towards both GP IIb/IIIa and GP Ib/IX receptors have a severe bleeding diathesis, and usually show poor prognosis to treatment with corticosteroids.

Original language	English
Pages (from-to)	94-98
Number of pages	5
Journal	Platelets
Volume	11
Issue number	2
DOIs	https://doi.org/10.1080/09537100075706
Publication status	Published - 2000
Externally published	Yes

ASJC Scopus subject areas

Hematology

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10.1080/09537100075706

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title = "Influence of auto-antibody specificities on the clinical course in patients with chronic and acute ITP",

abstract = "It is now well established that the target antigens of platelet auto-antibodies are the GP IIb/IIIa and GP Ib/IX receptors. In our study, it was observed that the majority of patients had antibodies directed towards the GP IIb/IIIa receptor, whereas the number of patients having antibodies directed towards the GP Ib/IX receptor was much less. Also, we found that the patients in whom the auto-antibodies are directed towards the GP IIb/IIIa receptors usually have mild bleeding. On the other hand, the patients having auto-antibodies directed towards both GP IIb/IIIa and GP Ib/IX receptors have a severe bleeding diathesis, and usually show poor prognosis to treatment with corticosteroids.",

author = "Mehta, {Y. S.} and Pathare, {A. V.} and Badakere, {S. S.} and K. Ghosh and Dipika Mohanty",

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T1 - Influence of auto-antibody specificities on the clinical course in patients with chronic and acute ITP

AU - Mehta, Y. S.

AU - Pathare, A. V.

AU - Badakere, S. S.

AU - Ghosh, K.

AU - Mohanty, Dipika

PY - 2000

Y1 - 2000

N2 - It is now well established that the target antigens of platelet auto-antibodies are the GP IIb/IIIa and GP Ib/IX receptors. In our study, it was observed that the majority of patients had antibodies directed towards the GP IIb/IIIa receptor, whereas the number of patients having antibodies directed towards the GP Ib/IX receptor was much less. Also, we found that the patients in whom the auto-antibodies are directed towards the GP IIb/IIIa receptors usually have mild bleeding. On the other hand, the patients having auto-antibodies directed towards both GP IIb/IIIa and GP Ib/IX receptors have a severe bleeding diathesis, and usually show poor prognosis to treatment with corticosteroids.

AB - It is now well established that the target antigens of platelet auto-antibodies are the GP IIb/IIIa and GP Ib/IX receptors. In our study, it was observed that the majority of patients had antibodies directed towards the GP IIb/IIIa receptor, whereas the number of patients having antibodies directed towards the GP Ib/IX receptor was much less. Also, we found that the patients in whom the auto-antibodies are directed towards the GP IIb/IIIa receptors usually have mild bleeding. On the other hand, the patients having auto-antibodies directed towards both GP IIb/IIIa and GP Ib/IX receptors have a severe bleeding diathesis, and usually show poor prognosis to treatment with corticosteroids.

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Influence of auto-antibody specificities on the clinical course in patients with chronic and acute ITP

Abstract

ASJC Scopus subject areas

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