Indigenous marine diatoms as novel sources of bioactive peptides with antihypertensive and antioxidant properties

Ines Barkia, Lamya Al Haj, Azizah Abdul Hamid, Mutaharah Zakaria, Nazamid Saari, Fahad AL Zadjali

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Several bioactive compounds from microalgae have demonstrated diverse biological activities with positive effects on human health. However, the potential of bioactive peptides as functional foods is still undervalued. Therefore, the exploration of microalgae strains as sources of bioactive peptides could reveal strong and unique bioactivities, especially when these marine sources have never been explored before. For this aim, protein extracts from six indigenous marine diatoms were subjected to enzymatic hydrolysis using four proteases (flavourzyme, pepsin, papain and trypsin). The hydrolysates were then tested for angiotensin converting enzyme (ACE)-inhibitory, antioxidant and antihypertensive properties. Results showed that papain hydrolysates from all microalgae strains exhibited strong ACE-inhibitory activities and antioxidant properties. In particular, protein hydrolysates from Bellerochea malleus were found to reduce blood pressure properties of 17 mmHg after 5 days of oral administration to SHR animals. These results revealed the potential of bioactive peptides from indigenous marine diatoms for use as functional foods or nutraceuticals.

Original languageEnglish
JournalInternational Journal of Food Science and Technology
DOIs
Publication statusAccepted/In press - Jan 1 2018

Fingerprint

Microalgae
Diatoms
antihypertensive agents
Bacillariophyceae
Antioxidants
microalgae
Papain
functional foods
Antihypertensive Agents
Peptides
Functional Food
papain
peptidyl-dipeptidase A
Peptidyl-Dipeptidase A
peptides
Bioactivity
hydrolysates
antioxidants
Bellerochea
Malleus

Keywords

  • ACE-inhibitory activity
  • antihypertensive activity
  • antioxidant activity
  • marine microalgae
  • protein hydrolysates

ASJC Scopus subject areas

  • Food Science
  • Industrial and Manufacturing Engineering

Cite this

Indigenous marine diatoms as novel sources of bioactive peptides with antihypertensive and antioxidant properties. / Barkia, Ines; Al Haj, Lamya; Abdul Hamid, Azizah; Zakaria, Mutaharah; Saari, Nazamid; AL Zadjali, Fahad.

In: International Journal of Food Science and Technology, 01.01.2018.

Research output: Contribution to journalArticle

@article{4d6010eada114a31b55416d56a2ce2f3,
title = "Indigenous marine diatoms as novel sources of bioactive peptides with antihypertensive and antioxidant properties",
abstract = "Several bioactive compounds from microalgae have demonstrated diverse biological activities with positive effects on human health. However, the potential of bioactive peptides as functional foods is still undervalued. Therefore, the exploration of microalgae strains as sources of bioactive peptides could reveal strong and unique bioactivities, especially when these marine sources have never been explored before. For this aim, protein extracts from six indigenous marine diatoms were subjected to enzymatic hydrolysis using four proteases (flavourzyme, pepsin, papain and trypsin). The hydrolysates were then tested for angiotensin converting enzyme (ACE)-inhibitory, antioxidant and antihypertensive properties. Results showed that papain hydrolysates from all microalgae strains exhibited strong ACE-inhibitory activities and antioxidant properties. In particular, protein hydrolysates from Bellerochea malleus were found to reduce blood pressure properties of 17 mmHg after 5 days of oral administration to SHR animals. These results revealed the potential of bioactive peptides from indigenous marine diatoms for use as functional foods or nutraceuticals.",
keywords = "ACE-inhibitory activity, antihypertensive activity, antioxidant activity, marine microalgae, protein hydrolysates",
author = "Ines Barkia and {Al Haj}, Lamya and {Abdul Hamid}, Azizah and Mutaharah Zakaria and Nazamid Saari and {AL Zadjali}, Fahad",
year = "2018",
month = "1",
day = "1",
doi = "10.1111/ijfs.14006",
language = "English",
journal = "International Journal of Food Science and Technology",
issn = "0950-5423",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Indigenous marine diatoms as novel sources of bioactive peptides with antihypertensive and antioxidant properties

AU - Barkia, Ines

AU - Al Haj, Lamya

AU - Abdul Hamid, Azizah

AU - Zakaria, Mutaharah

AU - Saari, Nazamid

AU - AL Zadjali, Fahad

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Several bioactive compounds from microalgae have demonstrated diverse biological activities with positive effects on human health. However, the potential of bioactive peptides as functional foods is still undervalued. Therefore, the exploration of microalgae strains as sources of bioactive peptides could reveal strong and unique bioactivities, especially when these marine sources have never been explored before. For this aim, protein extracts from six indigenous marine diatoms were subjected to enzymatic hydrolysis using four proteases (flavourzyme, pepsin, papain and trypsin). The hydrolysates were then tested for angiotensin converting enzyme (ACE)-inhibitory, antioxidant and antihypertensive properties. Results showed that papain hydrolysates from all microalgae strains exhibited strong ACE-inhibitory activities and antioxidant properties. In particular, protein hydrolysates from Bellerochea malleus were found to reduce blood pressure properties of 17 mmHg after 5 days of oral administration to SHR animals. These results revealed the potential of bioactive peptides from indigenous marine diatoms for use as functional foods or nutraceuticals.

AB - Several bioactive compounds from microalgae have demonstrated diverse biological activities with positive effects on human health. However, the potential of bioactive peptides as functional foods is still undervalued. Therefore, the exploration of microalgae strains as sources of bioactive peptides could reveal strong and unique bioactivities, especially when these marine sources have never been explored before. For this aim, protein extracts from six indigenous marine diatoms were subjected to enzymatic hydrolysis using four proteases (flavourzyme, pepsin, papain and trypsin). The hydrolysates were then tested for angiotensin converting enzyme (ACE)-inhibitory, antioxidant and antihypertensive properties. Results showed that papain hydrolysates from all microalgae strains exhibited strong ACE-inhibitory activities and antioxidant properties. In particular, protein hydrolysates from Bellerochea malleus were found to reduce blood pressure properties of 17 mmHg after 5 days of oral administration to SHR animals. These results revealed the potential of bioactive peptides from indigenous marine diatoms for use as functional foods or nutraceuticals.

KW - ACE-inhibitory activity

KW - antihypertensive activity

KW - antioxidant activity

KW - marine microalgae

KW - protein hydrolysates

UR - http://www.scopus.com/inward/record.url?scp=85056117191&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85056117191&partnerID=8YFLogxK

U2 - 10.1111/ijfs.14006

DO - 10.1111/ijfs.14006

M3 - Article

JO - International Journal of Food Science and Technology

JF - International Journal of Food Science and Technology

SN - 0950-5423

ER -