Increased vasoocclusive crises in "O" blood group sickle cell disease patients: Association with underlying thrombospondin levels

M. Al Huneini, S. Alkindi, V. Panjwani, K. Al Falahi, B. Al Balushi, D. Gravel, C. H. Ho, R. Krishnamoorthy, A. V. Pathare

Research output: Contribution to journalArticle

1 Citation (Scopus)


Objectives: To explore the incidence of vaso-occlusive crisis (VOC) in Blood Group "O" sickle cell disease (SCD) patients, and correlate it with the blood group and thrombospondin (TSP) levels. Methods: In 89 consecutive SCD patients, blood samples were obtained for von Williebrand factor (vWF:Ag) antigen, collagen binding activity (CBA), ristocetin binding activity (RCo), blood group typing, C-reactive protein (CRP), high performance liquid chromatography (HPLC), Serum TSP 1 and TSP 2 levels, complete blood counts (CBC), lactic dehydrogenase (LDH) levels, liver function (LFT) and renal function tests (RFT) during VOC episodes and in steady state conditions. Results: In steady state SCD patients (n=72), "O" blood group patients (n=37) showed a significantly higher median serum TSP 1 and TSP 2 levels as compared to non-O blood group patients [n=35] [p <0.05, Mann-Whitney test]; with an inverse relation between vWF:Ag, Factor VIII:C and TSP levels. Furthermore, the serum TSP 1 and TSP 2 levels were significantly higher in patients presenting with acute VOC [n=17], as well as in those with repeated VOC's (group 1, n=16), especially amongst blood group "O" patients [p, <0.05, Mann-Whitney test]. Conclusions: The study demonstrates an inverse relation between TSP and vWF levels, in blood group "O" SCD patients, with an upregulation of the TSP levels. Expectedly, during active VOC crisis, the TSP 1 and TSP 2 levels were significantly elevated.

Original languageEnglish
Article numbere2017028
JournalMediterranean Journal of Hematology and Infectious Diseases
Issue number1
Publication statusPublished - 2017



  • Blood groups
  • SCD
  • TSP 1
  • TSP 2
  • VOC
  • vWD

ASJC Scopus subject areas

  • Hematology
  • Infectious Diseases

Cite this