Increased markers of oxidative stress in autistic children of the Sultanate of Oman

Musthafa M. Essa, Gilles J. Guillemin, Mostafa I. Waly, Marwan M. Al-Sharbati, Yahya M. Al-Farsi, Faruck L. Hakkim, Amanat Ali, Mohammed S. Al-Shafaee

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Autism spectrum disorder (ASD) is a neurodevelopmental disorder of early childhood, and an enumeration about its etiology and consequences is still limited. Oxidative stress-induced mechanisms are believed to be the major cause for ASD. In this study 19 autistic and 19 age-matched normal Omani children were recruited to analyze their degree of redox status and a prewritten consent was obtained. Blood was withdrawn from subjects in heparin-coated tube, and plasma was separated. Plasma oxidative stress indicators such as nitric oxide (NO), malondialdehyde (MDA), protein carbonyl, and lactate to pyruvate ratio were quantified using commercially available kits. A significant elevation was observed in the levels of NO, MDA, protein carbonyl, and lactate to pyruvate ratio in the plasma of Omani autistic children as compared to their age-matched controls. These oxidative stress markers are strongly associated with major cellular injury and manifest severe mitochondrial dysfunction in autistic pathology. Our results also suggest that oxidative stress might be involved in the pathogenesis of ASD, and these parameters could be considered as diagnostic markers to ensure the prevalence of ASD in Omani children. However, the oxidative stress-induced molecular mechanisms in ASD should be studied in detail.

Original languageEnglish
Pages (from-to)25-27
Number of pages3
JournalBiological Trace Element Research
Volume147
Issue number1-3
DOIs
Publication statusPublished - Jun 2012

Fingerprint

Oman
Oxidative stress
Oxidative Stress
Malondialdehyde
Pyruvic Acid
Plasmas
Lactic Acid
Nitric Oxide
Pathology
Oxidation-Reduction
Heparin
Proteins
Blood
Autism Spectrum Disorder
Wounds and Injuries

Keywords

  • Autism
  • Lipid peroxidation
  • Omani children
  • Oxidative stress
  • Reactive nitrogen species

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Inorganic Chemistry
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism

Cite this

Increased markers of oxidative stress in autistic children of the Sultanate of Oman. / Essa, Musthafa M.; Guillemin, Gilles J.; Waly, Mostafa I.; Al-Sharbati, Marwan M.; Al-Farsi, Yahya M.; Hakkim, Faruck L.; Ali, Amanat; Al-Shafaee, Mohammed S.

In: Biological Trace Element Research, Vol. 147, No. 1-3, 06.2012, p. 25-27.

Research output: Contribution to journalArticle

Essa, Musthafa M. ; Guillemin, Gilles J. ; Waly, Mostafa I. ; Al-Sharbati, Marwan M. ; Al-Farsi, Yahya M. ; Hakkim, Faruck L. ; Ali, Amanat ; Al-Shafaee, Mohammed S. / Increased markers of oxidative stress in autistic children of the Sultanate of Oman. In: Biological Trace Element Research. 2012 ; Vol. 147, No. 1-3. pp. 25-27.
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