TY - JOUR
T1 - Increased markers of oxidative stress in autistic children of the Sultanate of Oman
AU - Essa, Musthafa M.
AU - Guillemin, Gilles J.
AU - Waly, Mostafa I.
AU - Al-Sharbati, Marwan M.
AU - Al-Farsi, Yahya M.
AU - Hakkim, Faruck L.
AU - Ali, Amanat
AU - Al-Shafaee, Mohammed S.
N1 - Funding Information:
Acknowledgments The project was supported by Sultan Qaboos University; Oman in the form of internal grant is gratefully acknowledged (IG/AGR/FOOD/11/02).
PY - 2012/6
Y1 - 2012/6
N2 - Autism spectrum disorder (ASD) is a neurodevelopmental disorder of early childhood, and an enumeration about its etiology and consequences is still limited. Oxidative stress-induced mechanisms are believed to be the major cause for ASD. In this study 19 autistic and 19 age-matched normal Omani children were recruited to analyze their degree of redox status and a prewritten consent was obtained. Blood was withdrawn from subjects in heparin-coated tube, and plasma was separated. Plasma oxidative stress indicators such as nitric oxide (NO), malondialdehyde (MDA), protein carbonyl, and lactate to pyruvate ratio were quantified using commercially available kits. A significant elevation was observed in the levels of NO, MDA, protein carbonyl, and lactate to pyruvate ratio in the plasma of Omani autistic children as compared to their age-matched controls. These oxidative stress markers are strongly associated with major cellular injury and manifest severe mitochondrial dysfunction in autistic pathology. Our results also suggest that oxidative stress might be involved in the pathogenesis of ASD, and these parameters could be considered as diagnostic markers to ensure the prevalence of ASD in Omani children. However, the oxidative stress-induced molecular mechanisms in ASD should be studied in detail.
AB - Autism spectrum disorder (ASD) is a neurodevelopmental disorder of early childhood, and an enumeration about its etiology and consequences is still limited. Oxidative stress-induced mechanisms are believed to be the major cause for ASD. In this study 19 autistic and 19 age-matched normal Omani children were recruited to analyze their degree of redox status and a prewritten consent was obtained. Blood was withdrawn from subjects in heparin-coated tube, and plasma was separated. Plasma oxidative stress indicators such as nitric oxide (NO), malondialdehyde (MDA), protein carbonyl, and lactate to pyruvate ratio were quantified using commercially available kits. A significant elevation was observed in the levels of NO, MDA, protein carbonyl, and lactate to pyruvate ratio in the plasma of Omani autistic children as compared to their age-matched controls. These oxidative stress markers are strongly associated with major cellular injury and manifest severe mitochondrial dysfunction in autistic pathology. Our results also suggest that oxidative stress might be involved in the pathogenesis of ASD, and these parameters could be considered as diagnostic markers to ensure the prevalence of ASD in Omani children. However, the oxidative stress-induced molecular mechanisms in ASD should be studied in detail.
KW - Autism
KW - Lipid peroxidation
KW - Omani children
KW - Oxidative stress
KW - Reactive nitrogen species
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U2 - 10.1007/s12011-011-9280-x
DO - 10.1007/s12011-011-9280-x
M3 - Article
C2 - 22127832
AN - SCOPUS:84861615319
SN - 0163-4984
VL - 147
SP - 25
EP - 27
JO - Biological Trace Element Research
JF - Biological Trace Element Research
IS - 1-3
ER -
