Inclusion complexes of norepinephrine with β-cyclodextrin, 18-crown-6 and cucurbit[7]uril

experimental and molecular dynamics study

Suad K S Al-Burtomani, Fakhr Eldin O Suliman

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The formation of binary and ternary inclusion complexes of norepinephrine, NP, with β-cyclodextrin (βCD), cucurbit[7]uril (CB7) and 18-crown-6 (18C6) have been investigated. Fluorescence spectroscopy revealed the enhancement of emission at around 312 nm from NP in the presence of βCD. However, in the presence of CB7 and 18C6 this band was quenched and the spectra exhibited an excimer emission at longer wavelength due to aggregation of guest molecules. The stoichiometry of the inclusion complexes has been investigated by electrospray mass spectrometry (ESI-MS) revealing the presence of binary and ternary complexes of NP with the hosts studied. On the other hand, the solid complexes prepared by lyophilization were characterized by FT-IR, Raman spectroscopy and powder X-ray crystallography. Our data, taken together, clearly suggest that the three hosts form stable complexes with NP. Additionally, we performed molecular dynamics simulations on these complexes in aqueous media for 15-20 ns. The results obtained indicated that hydrophobic forces together with extensive hydrogen bonding are responsible for the stability of these complexes.

Original languageEnglish
Pages (from-to)9888-9901
Number of pages14
JournalRSC Advances
Volume7
Issue number16
DOIs
Publication statusPublished - 2017

Fingerprint

Norepinephrine
Cyclodextrins
Molecular dynamics
X ray crystallography
Fluorescence spectroscopy
Stoichiometry
Powders
Mass spectrometry
Raman spectroscopy
Hydrogen bonds
Agglomeration
Wavelength
Molecules
Computer simulation
cucurbit(7)uril
18-crown-6

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

Inclusion complexes of norepinephrine with β-cyclodextrin, 18-crown-6 and cucurbit[7]uril : experimental and molecular dynamics study. / Al-Burtomani, Suad K S; Suliman, Fakhr Eldin O.

In: RSC Advances, Vol. 7, No. 16, 2017, p. 9888-9901.

Research output: Contribution to journalArticle

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