In vivo evidence of hepato- and reno-protective effect of garlic oil against sodium nitrite-induced oxidative stress

Hanaa A. Hassan, Sherif M. El-Agmy, Rajiv L. Gaur, Augusta Fernando, Madhwa H G Raj, Allal Ouhtit

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Sodium nitrite (NaNO2), a food color fixative and preservative, contributes to carcinogenesis. We investigated the protective role of garlic oil against NaNO2-induced abnormalities in metabolic biochemical parameters and oxidative status in male albino rats. NaNO2 treatment for a period of three months induced a significant increase in serum levels of glucose, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), bilirubin, urea and creatinine as well as hepatic AST and ALT. However, significant decrease was recorded in liver ALP activity, glycogen content, and renal urea and creatinine levels. In parallel, a significant increase in lipid peroxidation, and a decrease in glutathione content and catalase activity were observed in the liver and the kidney. However, garlic oil supplementation showed a remarkable amelioration of these abnormalities. Our data indicate that garlic is a phytoantioxidant with powerful chemopreventive properties against chemically-induced oxidative stress.

Original languageEnglish
Pages (from-to)249-255
Number of pages7
JournalInternational Journal of Biological Sciences
Volume5
Issue number3
Publication statusPublished - Mar 10 2009

Keywords

  • Alanine aminotransfrase
  • Alkaline phoasphatase
  • Aspartate aminotransfrease
  • Food additives
  • Garlic oil
  • Glycogen
  • Liver
  • Oxidative stress
  • Sodium nitrite

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology
  • Molecular Biology
  • Ecology, Evolution, Behavior and Systematics
  • Applied Microbiology and Biotechnology

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  • Cite this

    Hassan, H. A., El-Agmy, S. M., Gaur, R. L., Fernando, A., Raj, M. H. G., & Ouhtit, A. (2009). In vivo evidence of hepato- and reno-protective effect of garlic oil against sodium nitrite-induced oxidative stress. International Journal of Biological Sciences, 5(3), 249-255.