In-vitro virucidal and virustatic anti HIV-1 effects of extracts from Persea americana Mill. (avocado) leaves

M. D. Wigg, A. A. Al-Jabri, S. S. Costa, E. Race, B. Bodo, U. S. Oxford

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18 Citations (Scopus)

Abstract

Aqueous (PA1) and methanolic extracts (PA2a-d; PA3) from the tropical tree Persea americana Mill. (Lauraceae), were evaluated for their cellular toxicity and anti-HIV-1 activity both in virustatic and virucidal assays. With the exception of PA3 and PA2d, all extracts showed anti-HIV-1 activity at concentrations which were not toxic for the H9 indicator cells. From the methanol insoluble extract (PA2) four different fractions (PA2a-d) were obtained using reverse-phase column chromatography, and two of the fractions (b and c) showed detectable virucidal effect. One fraction (PA2a) showed virustatic effects inhibiting HIV syncytium formation and Viral p24 antigen formation at concentrations which were not toxic for the indicator cells. The results demonstrate for the first time that extracts from P. americana leaves have moderate anti-HIV-1 activity in vitro.

Original languageEnglish
Pages (from-to)179-183
Number of pages5
JournalAntiviral Chemistry and Chemotherapy
Volume7
Issue number4
Publication statusPublished - 1996

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Keywords

  • Antiviral activity
  • H9 cells
  • HIV
  • In vitro
  • Plant extract

ASJC Scopus subject areas

  • Virology
  • Pharmacology

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