TY - JOUR
T1 - Improving outcomes in advanced lung cancer
T2 - Maintenance therapy in non-small-cell lung carcinoma
AU - Furrukh, Muhammad
AU - Burney, Ikram A.
AU - Kumar, Shiyam
AU - Zahid, Khwaja F.
AU - Al-Moundhri, Mansour
PY - 2013/2
Y1 - 2013/2
N2 - Systemic chemotherapy has remained the traditional treatment for metastatic non-small-cell lung carcinoma (NSCLC), enhancing survival rate at 1 year to 29%. The median survival had plateaued at around 10 months until early 2008, and in an attempt to enhance survival in advanced disease, maintenance chemotherapy trials were initiated which had recently demonstrated prolongation of survival by an additional 2-3 months in patients who had performance status (PS) 0-1 and well-preserved organ functions. Suitable patients with any degree of clinical benefit are treated with 4-6 cycles, and then one of the active agents is continued until best response, or toxicity (continued maintenance), or changed to a cross non-resistant single agent (switch maintenance). The article briefly reviews the evolution of systemic therapy and describes key randomised trials of maintenance therapy instituting chemotherapy and targeted agents in an attempt to improve outcomes in advanced metastatic NSCLC, based on certain clinical features, histology, and genetics.
AB - Systemic chemotherapy has remained the traditional treatment for metastatic non-small-cell lung carcinoma (NSCLC), enhancing survival rate at 1 year to 29%. The median survival had plateaued at around 10 months until early 2008, and in an attempt to enhance survival in advanced disease, maintenance chemotherapy trials were initiated which had recently demonstrated prolongation of survival by an additional 2-3 months in patients who had performance status (PS) 0-1 and well-preserved organ functions. Suitable patients with any degree of clinical benefit are treated with 4-6 cycles, and then one of the active agents is continued until best response, or toxicity (continued maintenance), or changed to a cross non-resistant single agent (switch maintenance). The article briefly reviews the evolution of systemic therapy and describes key randomised trials of maintenance therapy instituting chemotherapy and targeted agents in an attempt to improve outcomes in advanced metastatic NSCLC, based on certain clinical features, histology, and genetics.
KW - Carcinoma
KW - Epidermal growth factor
KW - Lung neoplasm
KW - Maintenance chemotherapy
KW - Molecular targeted therapy
KW - Non-small-cell lung
KW - Receptor
KW - Vascular endothelial growth factor A
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UR - http://www.scopus.com/inward/citedby.url?scp=84875138134&partnerID=8YFLogxK
U2 - 10.12816/0003190
DO - 10.12816/0003190
M3 - Review article
AN - SCOPUS:84875138134
SN - 2075-051X
VL - 13
SP - 3
EP - 18
JO - Sultan Qaboos University Medical Journal
JF - Sultan Qaboos University Medical Journal
IS - 1
ER -
