Improvement of endothelial function by pitavastatin: a meta-analysis

Niki Katsiki, Željko Reiner, Eugenia Tedeschi Reiner, Khalid Al-Rasadi, Matteo Pirro, Dimitri P. Mikhailidis, Amirhossein Sahebkar

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objective. Dyslipidemia is commonly associated with endothelial dysfunction and increased cardiovascular risk. Pitavastatin has been shown to reduce total and low-density lipoprotein cholesterol, to increase high-density lipoprotein (HDL)-cholesterol and improve HDL function. Furthermore, several trials explored its effects on flow-mediated dilation (FMD), as an index of endothelial function. The authors evaluated the effect of pitavastatin therapy on FMD. Methods. The authors performed a systematic review and meta-analysis of all clinical trials exploring the impact of pitavastatin on FMD. The search included PubMed-Medline, Scopus, ISI Web of Knowledge and Google Scholar databases. Quantitative data synthesis was performed using a random-effects model, with weighted mean difference (WMD) and 95% confidence interval (CI) as summary statistics. Results. Six eligible studies comprising 7 treatment arms were selected for this meta-analysis. Overall, WMD was significant for the effect of pitavastatin on FMD (2.45%, 95% CI: 1.31, 3.60, p < 0.001) and the effect size was robust in the leave-one-out sensitivity analysis. Conclusion. This meta-analysis of all available clinical trials revealed a significant increase of FMD induced by pitavastatin.

Original languageEnglish
Pages (from-to)279-286
Number of pages8
JournalExpert Opinion on Pharmacotherapy
Volume19
Issue number3
DOIs
Publication statusPublished - Feb 11 2018

Keywords

  • atherosclerosis
  • endothelial function
  • flow-mediated dilation
  • meta-analysis
  • Pitavastatin

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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    Katsiki, N., Reiner, Ž., Tedeschi Reiner, E., Al-Rasadi, K., Pirro, M., Mikhailidis, D. P., & Sahebkar, A. (2018). Improvement of endothelial function by pitavastatin: a meta-analysis. Expert Opinion on Pharmacotherapy, 19(3), 279-286. https://doi.org/10.1080/14656566.2018.1428560