Importance of fluorine in benzazole compounds

Thuraya Al-Harthy*, Wajdi Zoghaib, Raid Abdel-Jalil

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

7 Citations (Scopus)

Abstract

Fluorine-containing heterocycles continue to receive considerable attention due to their unique properties. In medicinal chemistry, the incorporation of fluorine in small molecules imparts a significant enhancement their biological activities compared to non-fluorinated molecules. In this short review, we will highlight the importance of incorporating fluorine as a basic appendage in benzothiazole and benzimidazole skeletons. The chemistry and pharmacological activities of heterocycles containing fluorine during the past years are compiled and discussed.

Original languageEnglish
Article number4677
JournalMolecules
Volume25
Issue number20
DOIs
Publication statusPublished - Oct 2020
Externally publishedYes

Keywords

  • Benzazoles
  • Benzimidazoles
  • Benzothiazoles
  • Benzoxazole
  • Biological activities
  • Fluorine

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this