Abstract
Fluorine-containing heterocycles continue to receive considerable attention due to their unique properties. In medicinal chemistry, the incorporation of fluorine in small molecules imparts a significant enhancement their biological activities compared to non-fluorinated molecules. In this short review, we will highlight the importance of incorporating fluorine as a basic appendage in benzothiazole and benzimidazole skeletons. The chemistry and pharmacological activities of heterocycles containing fluorine during the past years are compiled and discussed.
Original language | English |
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Article number | 4677 |
Journal | Molecules |
Volume | 25 |
Issue number | 20 |
DOIs | |
Publication status | Published - Oct 2020 |
Keywords
- Benzazoles
- Benzimidazoles
- Benzothiazoles
- Benzoxazole
- Biological activities
- Fluorine
ASJC Scopus subject areas
- Analytical Chemistry
- Chemistry (miscellaneous)
- Molecular Medicine
- Pharmaceutical Science
- Drug Discovery
- Physical and Theoretical Chemistry
- Organic Chemistry