Impact of on Hepatic Low-Density Lipoprotein Uptake

Mohammad Jalili-Nik, Khadijeh Mahboobnia, Paul C Guest, Muhammed Majeed, Khalid Al-Rasadi, Tannaz Jamialahmadi, Amirhossein Sahebkar

Research output: Contribution to journalArticlepeer-review

Abstract

Elevated levels of plasma low-density lipoprotein cholesterol (LDL-C) are causally related to atherosclerotic cardiovascular disease. Enhancing the removal of LDL particles from the plasma, mainly by the liver, is the most efficient strategy for reducing LDL-C and the ensuing atherosclerosis. In this context, polyphenolic compounds like curcumin have generated interest owing to their lipid-modifying capacity. The promising effect of curcumin has been studied in attenuating atherosclerosis (in experimental models), and correcting dyslipidemia (in clinical studies). The underlying mechanisms of the effects of curcumin are relatively unknown, and the impact of curcumin on hepatic LDL uptake warrants further investigations. Here, we present a protocol to assess the effects of curcumin on LDL uptake in hepatocytes.

Original languageEnglish
Pages (from-to)395-400
Number of pages6
JournalMethods in molecular biology (Clifton, N.J.)
Volume2343
DOIs
Publication statusPublished - Sep 3 2021

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