Impact of on Hepatic Low-Density Lipoprotein Uptake

Mohammad Jalili-Nik; Khadijeh Mahboobnia; Paul C Guest; Muhammed Majeed; Khalid Al-Rasadi; Tannaz Jamialahmadi; Amirhossein Sahebkar

doi:10.1007/978-1-0716-1558-4_29

Impact of on Hepatic Low-Density Lipoprotein Uptake

Mohammad Jalili-Nik, Khadijeh Mahboobnia, Paul C Guest, Muhammed Majeed, Khalid Al-Rasadi, Tannaz Jamialahmadi, Amirhossein Sahebkar

Biochemistry

Research output: Contribution to journal › Article › peer-review

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Abstract

Elevated levels of plasma low-density lipoprotein cholesterol (LDL-C) are causally related to atherosclerotic cardiovascular disease. Enhancing the removal of LDL particles from the plasma, mainly by the liver, is the most efficient strategy for reducing LDL-C and the ensuing atherosclerosis. In this context, polyphenolic compounds like curcumin have generated interest owing to their lipid-modifying capacity. The promising effect of curcumin has been studied in attenuating atherosclerosis (in experimental models), and correcting dyslipidemia (in clinical studies). The underlying mechanisms of the effects of curcumin are relatively unknown, and the impact of curcumin on hepatic LDL uptake warrants further investigations. Here, we present a protocol to assess the effects of curcumin on LDL uptake in hepatocytes.

Original language	English
Pages (from-to)	395-400
Number of pages	6
Journal	Methods in molecular biology (Clifton, N.J.)
Volume	2343
DOIs	https://doi.org/10.1007/978-1-0716-1558-4_29
Publication status	Published - Sept 3 2021

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title = "Impact of on Hepatic Low-Density Lipoprotein Uptake",

abstract = "Elevated levels of plasma low-density lipoprotein cholesterol (LDL-C) are causally related to atherosclerotic cardiovascular disease. Enhancing the removal of LDL particles from the plasma, mainly by the liver, is the most efficient strategy for reducing LDL-C and the ensuing atherosclerosis. In this context, polyphenolic compounds like curcumin have generated interest owing to their lipid-modifying capacity. The promising effect of curcumin has been studied in attenuating atherosclerosis (in experimental models), and correcting dyslipidemia (in clinical studies). The underlying mechanisms of the effects of curcumin are relatively unknown, and the impact of curcumin on hepatic LDL uptake warrants further investigations. Here, we present a protocol to assess the effects of curcumin on LDL uptake in hepatocytes.",

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doi = "10.1007/978-1-0716-1558-4_29",

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T1 - Impact of on Hepatic Low-Density Lipoprotein Uptake

AU - Jalili-Nik, Mohammad

AU - Mahboobnia, Khadijeh

AU - Guest, Paul C

AU - Majeed, Muhammed

AU - Al-Rasadi, Khalid

AU - Jamialahmadi, Tannaz

AU - Sahebkar, Amirhossein

PY - 2021/9/3

Y1 - 2021/9/3

N2 - Elevated levels of plasma low-density lipoprotein cholesterol (LDL-C) are causally related to atherosclerotic cardiovascular disease. Enhancing the removal of LDL particles from the plasma, mainly by the liver, is the most efficient strategy for reducing LDL-C and the ensuing atherosclerosis. In this context, polyphenolic compounds like curcumin have generated interest owing to their lipid-modifying capacity. The promising effect of curcumin has been studied in attenuating atherosclerosis (in experimental models), and correcting dyslipidemia (in clinical studies). The underlying mechanisms of the effects of curcumin are relatively unknown, and the impact of curcumin on hepatic LDL uptake warrants further investigations. Here, we present a protocol to assess the effects of curcumin on LDL uptake in hepatocytes.

AB - Elevated levels of plasma low-density lipoprotein cholesterol (LDL-C) are causally related to atherosclerotic cardiovascular disease. Enhancing the removal of LDL particles from the plasma, mainly by the liver, is the most efficient strategy for reducing LDL-C and the ensuing atherosclerosis. In this context, polyphenolic compounds like curcumin have generated interest owing to their lipid-modifying capacity. The promising effect of curcumin has been studied in attenuating atherosclerosis (in experimental models), and correcting dyslipidemia (in clinical studies). The underlying mechanisms of the effects of curcumin are relatively unknown, and the impact of curcumin on hepatic LDL uptake warrants further investigations. Here, we present a protocol to assess the effects of curcumin on LDL uptake in hepatocytes.

U2 - 10.1007/978-1-0716-1558-4_29

DO - 10.1007/978-1-0716-1558-4_29

M3 - Article

C2 - 34473340

SN - 1064-3745

VL - 2343

SP - 395

EP - 400

JO - Methods in molecular biology (Clifton, N.J.)

JF - Methods in molecular biology (Clifton, N.J.)

ER -

Impact of on Hepatic Low-Density Lipoprotein Uptake

Abstract

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