Impact of nutrition on serum levels of docosahexaenoic acid among Omani children with autism

Yahya M. Al-Farsi; Mostafa I. Waly; Richard C. Deth; Marwan M. Al-Sharbati; Mohammed Al-Shafaee; Omar Al-Farsi; Maha M. Al-Khaduri; Samir Al-Adawi; Nathaniel W. Hodgson; Ishita Gupta; Allal Ouhtit

doi:10.1016/j.nut.2013.03.009

Impact of nutrition on serum levels of docosahexaenoic acid among Omani children with autism

Yahya M. Al-Farsi, Mostafa I. Waly, Richard C. Deth, Marwan M. Al-Sharbati, Mohammed Al-Shafaee, Omar Al-Farsi, Maha M. Al-Khaduri, Samir Al-Adawi, Nathaniel W. Hodgson, Ishita Gupta, Allal Ouhtit^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

Objectives: Autism is a lifelong neurodevelopmental disorder of early childhood. Dietary supplementation of the ω-3 fatty acid (docosahexaenoic acid [DHA]) during prenatal and postnatal life is considered a protective dietary intervention strategy to minimize the risk for autism spectrum disorder (ASD). To our knowledge, no relevant studies have been conducted in the Middle East investigating the status of DHA among children with autism during early childhood. The aim of this study was to investigate the serum levels and dietary intake status of DHA among Omani children recently diagnosed with ASD. Methods: The present case-control study involved 80 Omani children (<5 y), 40 cases and 40 controls matched for age and sex. A semi-quantitative food frequency questionnaire was used to assess dietary intake of all the participants, while serum levels of DHA were measured using high-performance liquid chromatography. Results: Our results showed that children with ASD had lower dietary consumption of foodstuff containing DHA, as well as lower serum levels of DHA than controls. Conclusion: The present finding from Oman supports the view of other studies that there are low serum levels of DHA among children with ASD.

Original language	English
Pages (from-to)	1142-1146
Number of pages	5
Journal	Nutrition
Volume	29
Issue number	9
DOIs	https://doi.org/10.1016/j.nut.2013.03.009
Publication status	Published - Sep 2013
Externally published	Yes

Keywords

Autism
Diet
Docosahexaenoic acid
Omani children

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Nutrition and Dietetics

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10.1016/j.nut.2013.03.009

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Impact of nutrition on serum levels of docosahexaenoic acid among Omani children with autism. / Al-Farsi, Yahya M.; Waly, Mostafa I.; Deth, Richard C.; Al-Sharbati, Marwan M.; Al-Shafaee, Mohammed; Al-Farsi, Omar; Al-Khaduri, Maha M.; Al-Adawi, Samir; Hodgson, Nathaniel W.; Gupta, Ishita; Ouhtit, Allal.

In: Nutrition, Vol. 29, No. 9, 09.2013, p. 1142-1146.

Research output: Contribution to journal › Article › peer-review

Al-Farsi, Yahya M. ; Waly, Mostafa I. ; Deth, Richard C. ; Al-Sharbati, Marwan M. ; Al-Shafaee, Mohammed ; Al-Farsi, Omar ; Al-Khaduri, Maha M. ; Al-Adawi, Samir ; Hodgson, Nathaniel W. ; Gupta, Ishita ; Ouhtit, Allal. / Impact of nutrition on serum levels of docosahexaenoic acid among Omani children with autism. In: Nutrition. 2013 ; Vol. 29, No. 9. pp. 1142-1146.

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title = "Impact of nutrition on serum levels of docosahexaenoic acid among Omani children with autism",

abstract = "Objectives: Autism is a lifelong neurodevelopmental disorder of early childhood. Dietary supplementation of the ω-3 fatty acid (docosahexaenoic acid [DHA]) during prenatal and postnatal life is considered a protective dietary intervention strategy to minimize the risk for autism spectrum disorder (ASD). To our knowledge, no relevant studies have been conducted in the Middle East investigating the status of DHA among children with autism during early childhood. The aim of this study was to investigate the serum levels and dietary intake status of DHA among Omani children recently diagnosed with ASD. Methods: The present case-control study involved 80 Omani children (<5 y), 40 cases and 40 controls matched for age and sex. A semi-quantitative food frequency questionnaire was used to assess dietary intake of all the participants, while serum levels of DHA were measured using high-performance liquid chromatography. Results: Our results showed that children with ASD had lower dietary consumption of foodstuff containing DHA, as well as lower serum levels of DHA than controls. Conclusion: The present finding from Oman supports the view of other studies that there are low serum levels of DHA among children with ASD.",

keywords = "Autism, Diet, Docosahexaenoic acid, Omani children",

author = "Al-Farsi, {Yahya M.} and Waly, {Mostafa I.} and Deth, {Richard C.} and Al-Sharbati, {Marwan M.} and Mohammed Al-Shafaee and Omar Al-Farsi and Al-Khaduri, {Maha M.} and Samir Al-Adawi and Hodgson, {Nathaniel W.} and Ishita Gupta and Allal Ouhtit",

note = "Funding Information: The authors extend their appreciation to all the staff at the outpatient clinic, both the Behavioral Medicine and the Child Health departments, Sultan Qaboos Univerity Hospital, for their cooperation and dedicated effort to complete this study. This study was supported by His Majesty Sultan Qaboos Grant (SR/MED/FMCO/11/01) and the Internal Grant (AGR/Food/IG/10/01) funds.",

year = "2013",

month = sep,

doi = "10.1016/j.nut.2013.03.009",

language = "English",

volume = "29",

pages = "1142--1146",

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T1 - Impact of nutrition on serum levels of docosahexaenoic acid among Omani children with autism

AU - Al-Farsi, Yahya M.

AU - Waly, Mostafa I.

AU - Deth, Richard C.

AU - Al-Sharbati, Marwan M.

AU - Al-Shafaee, Mohammed

AU - Al-Farsi, Omar

AU - Al-Khaduri, Maha M.

AU - Al-Adawi, Samir

AU - Hodgson, Nathaniel W.

AU - Gupta, Ishita

AU - Ouhtit, Allal

N1 - Funding Information: The authors extend their appreciation to all the staff at the outpatient clinic, both the Behavioral Medicine and the Child Health departments, Sultan Qaboos Univerity Hospital, for their cooperation and dedicated effort to complete this study. This study was supported by His Majesty Sultan Qaboos Grant (SR/MED/FMCO/11/01) and the Internal Grant (AGR/Food/IG/10/01) funds.

PY - 2013/9

Y1 - 2013/9

N2 - Objectives: Autism is a lifelong neurodevelopmental disorder of early childhood. Dietary supplementation of the ω-3 fatty acid (docosahexaenoic acid [DHA]) during prenatal and postnatal life is considered a protective dietary intervention strategy to minimize the risk for autism spectrum disorder (ASD). To our knowledge, no relevant studies have been conducted in the Middle East investigating the status of DHA among children with autism during early childhood. The aim of this study was to investigate the serum levels and dietary intake status of DHA among Omani children recently diagnosed with ASD. Methods: The present case-control study involved 80 Omani children (<5 y), 40 cases and 40 controls matched for age and sex. A semi-quantitative food frequency questionnaire was used to assess dietary intake of all the participants, while serum levels of DHA were measured using high-performance liquid chromatography. Results: Our results showed that children with ASD had lower dietary consumption of foodstuff containing DHA, as well as lower serum levels of DHA than controls. Conclusion: The present finding from Oman supports the view of other studies that there are low serum levels of DHA among children with ASD.

AB - Objectives: Autism is a lifelong neurodevelopmental disorder of early childhood. Dietary supplementation of the ω-3 fatty acid (docosahexaenoic acid [DHA]) during prenatal and postnatal life is considered a protective dietary intervention strategy to minimize the risk for autism spectrum disorder (ASD). To our knowledge, no relevant studies have been conducted in the Middle East investigating the status of DHA among children with autism during early childhood. The aim of this study was to investigate the serum levels and dietary intake status of DHA among Omani children recently diagnosed with ASD. Methods: The present case-control study involved 80 Omani children (<5 y), 40 cases and 40 controls matched for age and sex. A semi-quantitative food frequency questionnaire was used to assess dietary intake of all the participants, while serum levels of DHA were measured using high-performance liquid chromatography. Results: Our results showed that children with ASD had lower dietary consumption of foodstuff containing DHA, as well as lower serum levels of DHA than controls. Conclusion: The present finding from Oman supports the view of other studies that there are low serum levels of DHA among children with ASD.

KW - Autism

KW - Diet

KW - Docosahexaenoic acid

KW - Omani children

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Impact of nutrition on serum levels of docosahexaenoic acid among Omani children with autism

Abstract

Keywords

ASJC Scopus subject areas

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