Impact of Digoxin on Mortality in Patients with Atrial Fibrillation Stratified by Heart Failure: Findings from Gulf Survey of Atrial Fibrillation Events in the Middle East

Ibrahim Al-Zakwani, P. Panduranga, M. Zubaid, K. Sulaiman, W. A. Rashed, A. A. Alsheikh-Ali, W. Almahmeed, A. Shehab, A. Al Qudaimi, N. Asaad, H. Amin

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Objective: The use of digoxin in patients having atrial fibrillation (AF) with or without heart failure (HF) is not without controversy. The aim of this study was to examine the impact of digoxin therapy on mortality stratified by HF. Methods: Gulf Survey of Atrial Fibrillation Events was a prospective, multinational, observational registry of consecutive patients with AF recruited from the emergency department of 23 hospitals in 6 countries in the Middle East. Patients were recruited between October 2009 and June 2010 and followed up for 1 year after enrollment. Analyses were performed using univariate and multivariate statistical techniques. Results: The study included a total of 1962 patients with AF, with an overall mean age of 56 ± 16 years, and 52% (n = 1026) were males. At hospital discharge, digoxin was prescribed in 36% (n = 709) of the patients, whereas HF was present in 27% (n = 528) of the cohort. A total of 225 (12.1%) patients died during the 12-month follow-up period after discharge (5.3% [n = 104] were lost to follow-up). Patients with HF were consistently associated with higher mortality at 1 month (5.1% vs 2.1%; P

Original languageEnglish
Pages (from-to)273-279
Number of pages7
JournalJournal of Cardiovascular Pharmacology and Therapeutics
Issue number3
Publication statusPublished - 2015



  • atrial fibrillation
  • digoxin
  • heart failure
  • middle east
  • mortality

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Cardiology and Cardiovascular Medicine

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