Impact of Clopidogrel on Mortality in Patients With Acute Heart Failure Stratified by Coronary Artery Disease: Findings From the Arabian Gulf Acute Heart Failure Registry (Gulf CARE)

Ibrahim Al-Zakwani, Prashanth Panduranga, Jawad A. Al-Lawati, Kadhim Sulaiman, Alawi A. Alsheikh-Ali, Khalid F. AlHabib, Jassim Al Suwaidi, Wael Al-Mahmeed, Hussam AlFaleh, Omar Alnobani, Ahmed Al-Motarreb, Mustafa Ridha, Bassam Bulbanat, Mohammed Al-Jarallah, Nooshin Bazargani, Nidal Asaad, Haitham Amin

Research output: Contribution to journalArticle

Abstract

We evaluated the impact of clopidogrel use on 3- and 12-months all-cause mortality in patients with acute heart failure (AHF) stratified by coronary artery disease (CAD) in patients admitted to 47 hospitals in 7 Middle Eastern countries with AHF from February to November 2012. Clopidogrel use was associated with significantly lower risk of all-cause mortality at 3 months (adjusted odds ratio [aOR], 0.61; 95% confidence interval [CI]: 0.42-0.87; P =.007) and 12 months (aOR, 0.61; 95% CI: 0.47-0.79; P <.001). When the analysis was stratified by CAD, the clopidogrel group in those with AHF and CAD was also associated with significantly lower risk of all-cause mortality at 3 months (aOR, 0.56; 95% CI: 0.38-0.83; P =.003) and 12 months (aOR, 0.58; 95% CI: 0.44-0.77; P <.001). However, in AHF patients without CAD, clopidogrel use was not associated with any survival advantages, neither at 3 months (aOR, 0.99; 95% CI: 0.32-3.11; P =.987) nor at 12 months (aOR, 0.80; 95% CI: 0.37-1.72; P =.566). Clopidogrel use was associated with short- and long-term all-cause mortality in patients with AHF and CAD. In AHF patients without CAD, clopidogrel use did not offer any survival advantage.

Original languageEnglish
Pages (from-to)884-891
Number of pages8
JournalAngiology
Volume69
Issue number10
DOIs
Publication statusPublished - Nov 1 2018

Keywords

  • Arabs
  • clopidogrel
  • coronary artery disease
  • heart failure
  • Middle East
  • mortality

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Al-Zakwani, I., Panduranga, P., Al-Lawati, J. A., Sulaiman, K., Alsheikh-Ali, A. A., AlHabib, K. F., Suwaidi, J. A., Al-Mahmeed, W., AlFaleh, H., Alnobani, O., Al-Motarreb, A., Ridha, M., Bulbanat, B., Al-Jarallah, M., Bazargani, N., Asaad, N., & Amin, H. (2018). Impact of Clopidogrel on Mortality in Patients With Acute Heart Failure Stratified by Coronary Artery Disease: Findings From the Arabian Gulf Acute Heart Failure Registry (Gulf CARE). Angiology, 69(10), 884-891. https://doi.org/10.1177/0003319718775552