TY - JOUR
T1 - Impact of anemia on in-hospital, one-month and one-year mortality in patients with acute coronary syndrome from the Middle East
AU - Sulaiman, Kadhim
AU - Prashanth, Panduranga
AU - Al-Zakwani, Ibrahim
AU - Al-Mahmeed, Wael
AU - Al-Motarreb, Ahmed
AU - Al Suwaidi, Jassim
AU - Amin, Haitham
AU - Asaad, Nidal
AU - Hersi, Ahmad
AU - Al Faleh, Hussam A.
AU - Al Saif, Shukri A.
AU - Alsheikh-Ali, Alawi A.
AU - Al Lawati, Jawad
AU - Al-Habib, Khalid
PY - 2012/5/1
Y1 - 2012/5/1
N2 - Aim: The aim of this study was to evaluate the impact of admission anemia on in-hospital, one-month, and one-year mortality in patients from the Middle East with acute coronary syndrome (ACS). Methods: Data were analyzed from 7922 consecutive patients admitted to hospitals throughout six Middle-Eastern countries with the final diagnosis of ACS, as part of Gulf RACE II (Registry of Acute Coronary Events II). Anemia at admission was defined according to the World Health Organization definition (<13 g/dL in men and <12 g/dL in women). Analyses were conducted using univariate and multivariate statistical techniques. Results: The median age of the cohort was 56 (48-65) years, with the majority being male (79%). Anemia at admission was present in 2241 patients (28%). Patients with anemia were more likely to have in-hospital complications including heart failure, recurrent ischemia, re-infarction, cardiogenic shock, stroke, and major bleed. Even after adjustment, anemia was still associated with mortality at in-hospital (odds ratio [OR]=1.71, 95% confidence interval [CI], 1.34-2.17; P<0.001), at one-month (OR=1.34, 95% CI, 1.06-1.71; P=0.016), and at one-year (OR=1.22, 95% CI, 1.01-1.49; P=0.049) post- admission with ACS. Conclusions: Admission anemia in patients with ACS from six Middle-Eastern countries was strongly associated with mortality at in-hospital, one-month, and at one-year. Hence, admission anemia must be considered in the initial risk assessment of ACS patients along with other risk scores.
AB - Aim: The aim of this study was to evaluate the impact of admission anemia on in-hospital, one-month, and one-year mortality in patients from the Middle East with acute coronary syndrome (ACS). Methods: Data were analyzed from 7922 consecutive patients admitted to hospitals throughout six Middle-Eastern countries with the final diagnosis of ACS, as part of Gulf RACE II (Registry of Acute Coronary Events II). Anemia at admission was defined according to the World Health Organization definition (<13 g/dL in men and <12 g/dL in women). Analyses were conducted using univariate and multivariate statistical techniques. Results: The median age of the cohort was 56 (48-65) years, with the majority being male (79%). Anemia at admission was present in 2241 patients (28%). Patients with anemia were more likely to have in-hospital complications including heart failure, recurrent ischemia, re-infarction, cardiogenic shock, stroke, and major bleed. Even after adjustment, anemia was still associated with mortality at in-hospital (odds ratio [OR]=1.71, 95% confidence interval [CI], 1.34-2.17; P<0.001), at one-month (OR=1.34, 95% CI, 1.06-1.71; P=0.016), and at one-year (OR=1.22, 95% CI, 1.01-1.49; P=0.049) post- admission with ACS. Conclusions: Admission anemia in patients with ACS from six Middle-Eastern countries was strongly associated with mortality at in-hospital, one-month, and at one-year. Hence, admission anemia must be considered in the initial risk assessment of ACS patients along with other risk scores.
KW - Acute coronary syndrome
KW - Anemia
KW - Hemoglobin
KW - Middle East
KW - Mortality
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U2 - 10.3121/cmr.2011.1032
DO - 10.3121/cmr.2011.1032
M3 - Article
C2 - 22593012
AN - SCOPUS:84861505734
VL - 10
SP - 65
EP - 71
JO - Clinical Medicine and Research
JF - Clinical Medicine and Research
SN - 1539-4182
IS - 2
ER -