Immunoreactivity of ubiqitin in human prostate gland

Ziad M. Bataineh*, Omar Habbal

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Background: Ubiquitin is a low molecular weight protein which has been detected in a variety of normal and cancerous tissues. It is involved in many regulatory processes including protein proteolysis. It has been implicated in tumor pathogenesis. The role of ubiquitin in human prostate gland is investigated in this study. Methods: In this study, we utilized immunohistochemistry technique to localize ubiqitin in human prostate gland and correlate it with different pathological conditions of the prostate. Results: Ubiqitin was localized in normal, benign prostatic hyperplasia (BPH) and prostatic adenocarcinoma with variations in the distribution and intensity. In BPH, ubiquitin immunoreactivity was localized mainly in the nuclei while in the adenocarcinoma was localized mainly in the cytoplasm. Conclusion: The presence of ubiquitin mainly in the nuclei and in the cytoplasm of BPH and prostatic adenocarcinoma, respectively, may suggest a role of ubiquitin in the development of the above mentioned conditions. Ubiquitin could be used as a potential marker for the diagnosis and prognosis of pathological conditions of the prostate.

Original languageEnglish
Pages (from-to)517-522
Number of pages6
JournalNeuroendocrinology Letters
Volume27
Issue number4
Publication statusPublished - Aug 2006

Keywords

  • Benign prostatic hyperplasia
  • Immunohistochemistry
  • Prostatic adenocarcinoma
  • Proteasome
  • Protein degradation

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)

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