Immunobiology of natural killer cells and bone marrow transplantation

Merging of basic and preclinical studies

William J. Murphy, Crystal Y. Koh, Arati Raziuddin, Michael Bennett, Dan L. Longo

Research output: Contribution to journalReview article

61 Citations (Scopus)

Abstract

Natural killer (NK) cells mediate acute rejection of bone marrow, but not solid tissue, allografts in lethally irradiated mice. Precisely how and why this rejection occurs is still unclear. In allogeneic bone marrow transplantation (BMT), a spectrum of results is possible; one result can be marrow graft failure due to host rejection of the graft by NK and T cells and, at the opposite spectrum, the occurrence of graft-versus-host disease (GVHD). Donor NK cells, however, appear capable of improving donor engraftment without giving rise to GVHD and thus may be of use as an immunotherapy following BMT. As NK-cell inhibitory receptors play a role in bone marrow cell rejection, these same inhibitory receptors may also affect NK responses towards tumor cells. It has been demonstrated that blocking the interaction of inhibitory receptors with MHC determinants on tumor cells can result in greater antitumor effects. Thus, NK cells are capable of mediating both positive and negative effects during BMT depending on whether they are of host versus donor origin and their state of activation. Understanding their role in BMT provides insights as to their physiological roles and points the way to potential clinical uses.

Original languageEnglish
Pages (from-to)279-289
Number of pages11
JournalImmunological Reviews
Volume181
DOIs
Publication statusPublished - 2001

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Bone Marrow Transplantation
Natural Killer Cells
Graft vs Host Disease
Bone Marrow
Natural Killer Cell Receptors
Natural Killer T-Cells
Homologous Transplantation
Graft Rejection
Bone Marrow Cells
Immunotherapy
Allografts
Neoplasms
Transplants

ASJC Scopus subject areas

  • Immunology

Cite this

Immunobiology of natural killer cells and bone marrow transplantation : Merging of basic and preclinical studies. / Murphy, William J.; Koh, Crystal Y.; Raziuddin, Arati; Bennett, Michael; Longo, Dan L.

In: Immunological Reviews, Vol. 181, 2001, p. 279-289.

Research output: Contribution to journalReview article

Murphy, William J. ; Koh, Crystal Y. ; Raziuddin, Arati ; Bennett, Michael ; Longo, Dan L. / Immunobiology of natural killer cells and bone marrow transplantation : Merging of basic and preclinical studies. In: Immunological Reviews. 2001 ; Vol. 181. pp. 279-289.
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