Idiopathic granulomatous mastitis

Diagnostic strategy and therapeutic implications in Omani patients

Adil Al-Jarrah, Varna Taranikanti, Ritu Lakhtakia, Asma Al-Jabri, Sukhpal Sawhney

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objectives: Idiopathic granulomatous mastitis (IGM) is a rare benign disorder of the breast whose aetiology is controversial, and is often misdiagnosed clinically and radiologically as mammary malignancy; as a result, it may be incorrectly treated. Although no standard treatment is available for this chronic disease, surgery with or without corticosteroids has been tried with controversial results. This study discusses the clinical presentation, diagnosis, management, recurrence, and follow-up data of IGM with a review of relevant literature. Methods: From 2009-2012, the Breast Unit at Sultan Qaboos University Hospital, Oman, conducted a clinical study on 20 patients with breast lumps. Their clinical and radiological examinations were indeterminate, and a diagnosis of granulomatous mastitis was established only by histopathology. Results: The majority of the patients were cases of unknown aetiology, who presented with a unilateral breast mass. A few patients had a mass with an abscess, along with axillary lymphadenopathy. A total of 4 patients were suspected of malignancy using radiology. In all patients, sterilised pus was sent for culture and sensitivity. Microscopy showed the characteristic pattern of granulomatous inflammation. All patients were treated with antibiotics for 6 weeks, and the mean follow-up period was 15 months (11-33 months). All patients had complete remission with no further recurrence. Conclusion: This single largest study of cases of IGM in Oman highlights the pitfalls in diagnosing this non-neoplastic disease of unknown aetiology and uncertain pathogenesis. It emphasises IGM's excellent response to antibiotics, which is crucial, as IGM is a disease which is notoriously difficult and controversial to treat.

Original languageEnglish
Pages (from-to)241-247
Number of pages7
JournalSultan Qaboos University Medical Journal
Volume13
Issue number2
Publication statusPublished - May 2013

Fingerprint

Granulomatous Mastitis
Breast
Oman
Therapeutics
Anti-Bacterial Agents
Recurrence
Suppuration
Diagnostic Errors
Radiology
Abscess
Microscopy
Neoplasms
Adrenal Cortex Hormones
Chronic Disease
Inflammation

Keywords

  • Antibiotics
  • Breast
  • Diagnosis
  • Granulomatous mastitis
  • Immunohistochemistry
  • Mammography
  • Oman
  • Pathology
  • Ultrasonography

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Idiopathic granulomatous mastitis : Diagnostic strategy and therapeutic implications in Omani patients. / Al-Jarrah, Adil; Taranikanti, Varna; Lakhtakia, Ritu; Al-Jabri, Asma; Sawhney, Sukhpal.

In: Sultan Qaboos University Medical Journal, Vol. 13, No. 2, 05.2013, p. 241-247.

Research output: Contribution to journalArticle

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