Hypertrophic Obstructive Cardiomyopathy in An Infant with Hemophagocytic Lymphohistiocytosis; Answer to a Riddle

Fatma Rabah; Ismail Beshlawi; Yasser Wali; Abdulhakim Al-Rawas; Khalfan Al Senaidi

doi:10.1097/MPH.0000000000000257

Hypertrophic Obstructive Cardiomyopathy in An Infant with Hemophagocytic Lymphohistiocytosis; Answer to a Riddle

Fatma Rabah, Ismail Beshlawi, Yasser Wali, Abdulhakim Al-Rawas, Khalfan Al Senaidi

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1 Citation (Scopus)

Abstract

Familial hemophagocytic lymphohistiocytosis (FHLH) is a hereditary hyperinflammatory condition with T-cell and macrophage activation. Treatment consists of immunosuppressive therapy plus bone marrow transplantation. Cardiac manifestations of FHLH were scarcely mentioned in the literature with conflicting pathophysiological explanations. We report a case of hypertrophic obstructive cardiomyopathy associated with FHLH. Guided by such a case, a clear vision regarding the real cause is thought to be obtained in the cloudy landscape of pathophysiology. ©

Original language	English
Pages (from-to)	459-461
Number of pages	3
Journal	Journal of Pediatric Hematology/Oncology
Volume	37
Issue number	6
DOIs	https://doi.org/10.1097/MPH.0000000000000257
Publication status	Published - Aug 6 2015

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Keywords

FHLH
hemophagocytic lymphohistiocytosis
high dose corticosteroid therapy
HOCM
hypertrophic obstructive cardiomyopathy
severe adverse event

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Oncology
Hematology
Medicine(all)

Cite this

Rabah, F., Beshlawi, I., Wali, Y., Al-Rawas, A., & Al Senaidi, K. (2015). Hypertrophic Obstructive Cardiomyopathy in An Infant with Hemophagocytic Lymphohistiocytosis; Answer to a Riddle. Journal of Pediatric Hematology/Oncology, 37(6), 459-461. https://doi.org/10.1097/MPH.0000000000000257

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Access to Document

10.1097/MPH.0000000000000257