Hypertrophic Obstructive Cardiomyopathy in An Infant with Hemophagocytic Lymphohistiocytosis; Answer to a Riddle

Fatma Rabah, Ismail Beshlawi, Yasser Wali, Abdulhakim Al-Rawas, Khalfan Al Senaidi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Familial hemophagocytic lymphohistiocytosis (FHLH) is a hereditary hyperinflammatory condition with T-cell and macrophage activation. Treatment consists of immunosuppressive therapy plus bone marrow transplantation. Cardiac manifestations of FHLH were scarcely mentioned in the literature with conflicting pathophysiological explanations. We report a case of hypertrophic obstructive cardiomyopathy associated with FHLH. Guided by such a case, a clear vision regarding the real cause is thought to be obtained in the cloudy landscape of pathophysiology. ©

Original languageEnglish
Pages (from-to)459-461
Number of pages3
JournalJournal of Pediatric Hematology/Oncology
Volume37
Issue number6
DOIs
Publication statusPublished - Aug 6 2015

Fingerprint

Hemophagocytic Lymphohistiocytosis
Hypertrophic Cardiomyopathy
Macrophage Activation
Immunosuppressive Agents
Bone Marrow Transplantation
T-Lymphocytes
Therapeutics

Keywords

  • FHLH
  • hemophagocytic lymphohistiocytosis
  • high dose corticosteroid therapy
  • HOCM
  • hypertrophic obstructive cardiomyopathy
  • severe adverse event

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Hematology
  • Medicine(all)

Cite this

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AU - Al Senaidi, Khalfan

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