Hyperhomocysteinemia among Omani autistic children: A case-control study

Amanat Ali, Mostafa I. Waly, Yahya M. Al-Farsi, Musthafa M. Essa, Marwan M. Al-Sharbati, Richard C. Deth

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

High serum homocysteine (Hcy) level is regarded as an indicator for impairment of folate-dependent methionine cycle and is associated with oxidative stress. In a case control study, we evaluated eighty 3-5 years old Omani children (40 diagnosed with Autism Spectrum Disorder and 40 their age and gender matched controls) for their fasting serum homocysteine levels as a biomarker of Autism Spectrum Disorder (ASD). Serum folate and vitamin B12 status were also evaluated. The serum homocysteine was measured using an enzyme immunoassay (EIA) technique whereas folate and vitamin B12 were measured using an automated random access immune-assay system. The results indicated that mean serum Hcy levels were significantly (P <0.05) higher in autistic children (20.1 ± 3.3 μmol/L) as compared to controls (9.64 ± 2.1 μmol/L). Significantly (P <0.05) lower serum folate (1.8 ± 0.4 μg/L) and vitamin B12 (191.1 ± 0.9 pg/mL) levels were observed in autistic children as compared to controls (6.1 ± 0.6 μg/L and 288.9 ± 1.3 pg/mL, respectively). The levels of homocysteine in autistic children were also much higher as compared to normal reference values (5-15 μmol/L). The results suggest that high fasting serum homocysteine and low folate and vitamin B12 levels could be used as clinical biomarkers for an early diagnosis and management of ASD.

Original languageEnglish
Pages (from-to)547-551
Number of pages5
JournalActa Biochimica Polonica
Volume58
Issue number4
Publication statusPublished - 2011

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Hyperhomocysteinemia
Homocysteine
Case-Control Studies
Folic Acid
Vitamin B 12
Serum
Biomarkers
Fasting
Reference Values
Oxidative stress
Methionine
Immunoenzyme Techniques
Assays
Early Diagnosis
Immune System
Oxidative Stress
Enzymes
Autism Spectrum Disorder

Keywords

  • Autistic children
  • Folate
  • Oman
  • Serum homocysteine
  • Vitamin B

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Hyperhomocysteinemia among Omani autistic children : A case-control study. / Ali, Amanat; Waly, Mostafa I.; Al-Farsi, Yahya M.; Essa, Musthafa M.; Al-Sharbati, Marwan M.; Deth, Richard C.

In: Acta Biochimica Polonica, Vol. 58, No. 4, 2011, p. 547-551.

Research output: Contribution to journalArticle

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