hTR RNA component as a marker of cellular proliferation in oral lichen planus

Cathal Ó Flatharta, Stephen Flint, Mary Toner, Mohamed Mabruk

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Previously, we have shown that the telomerase RNA component hTR is highly expressed in the epithelium of non-dysplastic Oral Lichen Planus (OLP) lesions (11). We concluded that it is possible that this high expression might be related to the increased cellular proliferation seen in OLP rather than being an indicator of potential malignant transformation. In the present study, and in order to confirm our finding in the previous study that hTR might be a marker for cellular proliferation in OLP, we analysed OLP biopsies known to be positive for RNA component of Telomerase (hTR) for the expression of Ki-67 as a marker for cellular proliferation. Fourteen OLP tissue biopsies known to be positive for telomerase RNA component hTR, were investigated using an immunohistochemical approach to determine the rate of cellular proliferation in OLP, looking at the expression of Ki-67 protein as a marker for cellular proliferation. A statistically significant increase was found between Ki-67 expression in OLP in comparison to normal control buccal mucosa samples. The expression of hTR component in OLP might thus be a marker for cellular proliferation.

Original languageEnglish
Pages (from-to)287-290
Number of pages4
JournalAsian Pacific Journal of Cancer Prevention
Volume9
Issue number2
Publication statusPublished - 2008

Keywords

  • Cellular proliferation
  • hTR
  • Marker
  • Oral lichen planus
  • Telomerase RNA component

ASJC Scopus subject areas

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

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