HOXB13, a potential prognostic biomarker for prostate cancer

Allal Ouhtit; Mohammed N. Al-Kindi; Parvathy R. Kumar; Ishita Gupta; Somya Shanmuganathan; Yahya Tamimi

doi:10.2741/e749

HOXB13, a potential prognostic biomarker for prostate cancer

Allal Ouhtit^*, Mohammed N. Al-Kindi, Parvathy R. Kumar, Ishita Gupta, Somya Shanmuganathan, Yahya Tamimi

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

19 Citations (Scopus)

Abstract

HOXB13, a member of the homeobox proteins family, is a key regulator of the epithelial differentiation in the prostate gland. HOXB13 is overexpressed during malignant progression of the prostatic tissue and suspected to contribute in the pathogenesis of the prostate gland. In androgen deprived conditions, HOXB13 is thought to act through inhibition of the tumour suppressor protein p21. Since HOXB13 has a multifaceted role in ventral prostate development, its critical partners in the cascade need to be elucidated for a further understanding of its role in prostate malignancy. In this report, we review the functions attributed to HOXB13, by highlighting the most recent findings supporting the hypothesis that HOXB13 might serve as a novel biomarker for the prognosis of prostate cancer.

Original language	English
Pages (from-to)	40-45
Number of pages	6
Journal	Frontiers in Bioscience - Elite
Volume	8
Issue number	1
DOIs	https://doi.org/10.2741/e749
Publication status	Published - Jan 1 2016

Keywords

Androgen
HOXB13
Prostate cancer
Review

ASJC Scopus subject areas

General Biochemistry,Genetics and Molecular Biology
General Immunology and Microbiology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2741/e749

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abstract = "HOXB13, a member of the homeobox proteins family, is a key regulator of the epithelial differentiation in the prostate gland. HOXB13 is overexpressed during malignant progression of the prostatic tissue and suspected to contribute in the pathogenesis of the prostate gland. In androgen deprived conditions, HOXB13 is thought to act through inhibition of the tumour suppressor protein p21. Since HOXB13 has a multifaceted role in ventral prostate development, its critical partners in the cascade need to be elucidated for a further understanding of its role in prostate malignancy. In this report, we review the functions attributed to HOXB13, by highlighting the most recent findings supporting the hypothesis that HOXB13 might serve as a novel biomarker for the prognosis of prostate cancer.",

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AU - Ouhtit, Allal

AU - Al-Kindi, Mohammed N.

AU - Kumar, Parvathy R.

AU - Gupta, Ishita

AU - Shanmuganathan, Somya

AU - Tamimi, Yahya

PY - 2016/1/1

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N2 - HOXB13, a member of the homeobox proteins family, is a key regulator of the epithelial differentiation in the prostate gland. HOXB13 is overexpressed during malignant progression of the prostatic tissue and suspected to contribute in the pathogenesis of the prostate gland. In androgen deprived conditions, HOXB13 is thought to act through inhibition of the tumour suppressor protein p21. Since HOXB13 has a multifaceted role in ventral prostate development, its critical partners in the cascade need to be elucidated for a further understanding of its role in prostate malignancy. In this report, we review the functions attributed to HOXB13, by highlighting the most recent findings supporting the hypothesis that HOXB13 might serve as a novel biomarker for the prognosis of prostate cancer.

AB - HOXB13, a member of the homeobox proteins family, is a key regulator of the epithelial differentiation in the prostate gland. HOXB13 is overexpressed during malignant progression of the prostatic tissue and suspected to contribute in the pathogenesis of the prostate gland. In androgen deprived conditions, HOXB13 is thought to act through inhibition of the tumour suppressor protein p21. Since HOXB13 has a multifaceted role in ventral prostate development, its critical partners in the cascade need to be elucidated for a further understanding of its role in prostate malignancy. In this report, we review the functions attributed to HOXB13, by highlighting the most recent findings supporting the hypothesis that HOXB13 might serve as a novel biomarker for the prognosis of prostate cancer.

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KW - Review

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HOXB13, a potential prognostic biomarker for prostate cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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