HLA-A68 and HLA-B15 alleles correlate with poor immune response among AIDS patients on combined antiretroviral therapy

Marah El-Beeli, Samira Hamad Al-Mahrooqi, Randa Mahmoud Youssef, Fahad Zadjali, Abdullah Balkhair, Mohammed Said Al-Balushi, Elias Anthony Said, Sidgi Syed Hasson, Ali Abdullah Al-Jabri*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Around 15–30% of AIDS patients fail to recover their CD4+ T cell levels following combined antiretroviral therapy despite successful inhibition of HIV-1 replication. The exact reasons for this immune recovery failure are not completely understood. HLA alleles are among the candidate that may explain this failure. A total of 65 adult AIDS patients, with viral load of <50 copies per ml were investigated. Viral load and CD4 T cells counts were performed following standard techniques. HLA genotyping was performed using PCR-SSP technique. The Statistical Package for Social Sciences (SPSS version 19) was used for data processing and analysis. A significantly higher proportion of poor immune responders were carrying HLA-A68 (4.8% compared to 25.0%, P = 0.025) and HLA-B15 (2.4% compared to 20.8%, P = 0.023). The etiological fraction (Efe%) among carriers of HLA-A68 was 57.89% (95% CI = 26.79, 75.79) and was 61.35% (95% CI = 35.33, 76.91) among carriers of HLA-B15.

Original languageEnglish
Pages (from-to)490-497
Number of pages8
JournalHuman Immunology
Volume77
Issue number6
DOIs
Publication statusPublished - 2016

Keywords

  • AIDS
  • CART
  • HIV
  • HLA
  • Immune response
  • Oman

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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