HLA-A68 and HLA-B15 alleles correlate with poor immune response among AIDS patients on combined antiretroviral therapy

Marah El-Beeli, Samira Hamad Al-Mahrooqi, Randa Mahmoud Youssef, Fahad Zadjali, Abdullah Balkhair, Mohammed Said Al-Balushi, Elias Anthony Said, Sidgi Syed Hasson, Ali Abdullah Al-Jabri

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Around 15-30% of AIDS patients fail to recover their CD4+ T cell levels following combined antiretroviral therapy despite successful inhibition of HIV-1 replication. The exact reasons for this immune recovery failure are not completely understood. HLA alleles are among the candidate that may explain this failure. A total of 65 adult AIDS patients, with viral load of

Original languageEnglish
JournalHuman Immunology
DOIs
Publication statusAccepted/In press - Feb 5 2014

Fingerprint

HLA-B15 Antigen
Acquired Immunodeficiency Syndrome
Alleles
Viral Load
HIV-1
T-Lymphocytes
Therapeutics

Keywords

  • AIDS
  • CART
  • HIV
  • HLA
  • Immune response
  • Oman

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

@article{1999fff1de4e434fbaa698c80749863b,
title = "HLA-A68 and HLA-B15 alleles correlate with poor immune response among AIDS patients on combined antiretroviral therapy",
abstract = "Around 15-30{\%} of AIDS patients fail to recover their CD4+ T cell levels following combined antiretroviral therapy despite successful inhibition of HIV-1 replication. The exact reasons for this immune recovery failure are not completely understood. HLA alleles are among the candidate that may explain this failure. A total of 65 adult AIDS patients, with viral load of",
keywords = "AIDS, CART, HIV, HLA, Immune response, Oman",
author = "Marah El-Beeli and Al-Mahrooqi, {Samira Hamad} and Youssef, {Randa Mahmoud} and Fahad Zadjali and Abdullah Balkhair and Al-Balushi, {Mohammed Said} and Said, {Elias Anthony} and Hasson, {Sidgi Syed} and Al-Jabri, {Ali Abdullah}",
year = "2014",
month = "2",
day = "5",
doi = "10.1016/j.humimm.2016.04.009",
language = "English",
journal = "Human Immunology",
issn = "0198-8859",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - HLA-A68 and HLA-B15 alleles correlate with poor immune response among AIDS patients on combined antiretroviral therapy

AU - El-Beeli, Marah

AU - Al-Mahrooqi, Samira Hamad

AU - Youssef, Randa Mahmoud

AU - Zadjali, Fahad

AU - Balkhair, Abdullah

AU - Al-Balushi, Mohammed Said

AU - Said, Elias Anthony

AU - Hasson, Sidgi Syed

AU - Al-Jabri, Ali Abdullah

PY - 2014/2/5

Y1 - 2014/2/5

N2 - Around 15-30% of AIDS patients fail to recover their CD4+ T cell levels following combined antiretroviral therapy despite successful inhibition of HIV-1 replication. The exact reasons for this immune recovery failure are not completely understood. HLA alleles are among the candidate that may explain this failure. A total of 65 adult AIDS patients, with viral load of

AB - Around 15-30% of AIDS patients fail to recover their CD4+ T cell levels following combined antiretroviral therapy despite successful inhibition of HIV-1 replication. The exact reasons for this immune recovery failure are not completely understood. HLA alleles are among the candidate that may explain this failure. A total of 65 adult AIDS patients, with viral load of

KW - AIDS

KW - CART

KW - HIV

KW - HLA

KW - Immune response

KW - Oman

UR - http://www.scopus.com/inward/record.url?scp=84964978177&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84964978177&partnerID=8YFLogxK

U2 - 10.1016/j.humimm.2016.04.009

DO - 10.1016/j.humimm.2016.04.009

M3 - Article

C2 - 27067905

AN - SCOPUS:84964978177

JO - Human Immunology

JF - Human Immunology

SN - 0198-8859

ER -