HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation

Nicolas Chomont, Mohamed El-Far, Petronela Ancuta, Lydie Trautmann, Francesco A. Procopio, Bader Yassine-Diab, Geneviève Boucher, Mohamed Rachid Boulassel, Georges Ghattas, Jason M. Brenchley, Timothy W. Schacker, Brenna J. Hill, Daniel C. Douek, Jean Pierre Routy, Elias K. Haddad, Rafick Pierre Sékaly

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963 Citations (Scopus)

Abstract

HIV persists in a reservoir of latently infected CD4+ T cells in individuals treated with highly active antiretroviral therapy (HAART). Here we identify central memory (T(CM)) and transitional memory (T(TM)) CD4+ T cells as the major cellular reservoirs for HIV and find that viral persistence is ensured by two different mechanisms. HIV primarily persists in T(CM) cells in subjects showing reconstitution of the CD4+ compartment upon HAART. This reservoir is maintained through T cell survival and low-level antigen-driven proliferation and is slowly depleted with time. In contrast, proviral DNA is preferentially detected in T(TM) cells from aviremic individuals with low CD4+ counts and higher amounts of interleukin-7-mediated homeostatic proliferation, a mechanism that ensures the persistence of these cells. Our results suggest that viral eradication might be achieved through the combined use of strategic interventions targeting viral replication and, as in cancer, drugs that interfere with the self renewal and persistence of proliferating memory T cells.

Original languageEnglish
Pages (from-to)893-900
Number of pages8
JournalNature Medicine
Volume15
Issue number8
DOIs
Publication statusPublished - Aug 2009

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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    Chomont, N., El-Far, M., Ancuta, P., Trautmann, L., Procopio, F. A., Yassine-Diab, B., Boucher, G., Boulassel, M. R., Ghattas, G., Brenchley, J. M., Schacker, T. W., Hill, B. J., Douek, D. C., Routy, J. P., Haddad, E. K., & Sékaly, R. P. (2009). HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation. Nature Medicine, 15(8), 893-900. https://doi.org/10.1038/nm.1972