Histomorphological spectrum of papillary carcinoma of thyroid in Oman

Asim Qureshi, Ibrahim Al Haddabi, Anna Saparamadu, Asmaa H. Al-Shehhi, Chandu di Silva

Research output: Contribution to journalArticle

Abstract

Thyroid cancer is the commonest endocrine malignancy and is the second most common cancer affecting young females in Oman. The diagnosis of Papillary Thyroid Carcinoma (PTC) is based primarily on histologic architecture and nuclear morphology in routine Haematoxilin and Eosin (H & E) stained slides. Whenever in doubt, immunohistochemistry may be helpful. This retrospective study included 115 cases of PTC diagnosed at a tertiary care center in Oman over 10 years period, from 2001 to 2010. Slides and blocks of these cases were retrieved from the pathology laboratory. Ninety five (95) were females and 20 were males. Papillary Thyroid Carcinoma (PTC) was most commonly seen in the 20 - 50 years of age. The commonest morphologic variant seen in this population was classical papillary variant in 44/115 (38%) followed by papillary micro-carcinoma (n=30/115, 26%) and follicular variant of papillary carcinoma (n=18/115, 15.6%). Out of the 30 micro-carcinoma cases, 18 were diagnosed incidentally in thyroids operated for multi-nodular goiter. Immunohistochemical marker CK-19 was positive in 29/31, HBME-1 and HMW-CK in 15/15 cases; CEA was in one case where it was reported negative. Immunohistochemical stains were useful in cases with atypical /doubtful morphology.

Original languageEnglish
Pages (from-to)467-468
Number of pages2
JournalJournal of the College of Physicians and Surgeons Pakistan
Volume25
Issue number6
Publication statusPublished - 2015

Fingerprint

Oman
Carcinoma, Papillary, Follicular
Nodular Goiter
Second Primary Neoplasms
Papillary Carcinoma
Eosine Yellowish-(YS)
Thyroid Neoplasms
Tertiary Care Centers
Thyroid Gland
Coloring Agents
Retrospective Studies
Immunohistochemistry
Pathology
Carcinoma
Population
Papillary Thyroid cancer
Neoplasms

Keywords

  • Immunohistochemistry
  • Papillary carcinoma
  • Thyroid

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Histomorphological spectrum of papillary carcinoma of thyroid in Oman. / Qureshi, Asim; Haddabi, Ibrahim Al; Saparamadu, Anna; Al-Shehhi, Asmaa H.; di Silva, Chandu.

In: Journal of the College of Physicians and Surgeons Pakistan, Vol. 25, No. 6, 2015, p. 467-468.

Research output: Contribution to journalArticle

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