Abstract
A simple, rapid and sensitive chemiluminescent (CL) method for the assay of venlafaxine (VEN) in pharmaceutical formulations and serum samples by a two-chip device is proposed. The method is based on the reaction of this drug with a tris(2,2′-bipyridyl) ruthenium(II)-peroxydisulphate CL system. The optimum chemical conditions for CL emission were investigated. The calibration graph was linear for the concentration range 0.02-8.0 μg/mL. The detection and quantification limits were found to be 0.006 and 0.018 μg/mL, respectively, while the relative standard deviation (RSD) was
| Original language | English |
|---|---|
| Pages (from-to) | 44-49 |
| Number of pages | 6 |
| Journal | Luminescence |
| Volume | 28 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2013 |
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Keywords
- chemiluminescence
- microfluidics
- Tris(2,2′-bipyridyl) ruthenium(II)
- two-chip device
- venlafaxine
ASJC Scopus subject areas
- Biophysics
- Chemistry (miscellaneous)
- Medicine(all)
Cite this
High-throughput method for the analysis of venlafaxine in pharmaceutical formulations and biological fluids, using a tris(2,2′-bipyridyl) ruthenium(II)-peroxydisulphate chemiluminescence system in a two-chip device. / Al Lawati, Haider A J; Varma, Gouri B.; Suliman, Fakhr Eldin O.
In: Luminescence, Vol. 28, No. 1, 01.2013, p. 44-49.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - High-throughput method for the analysis of venlafaxine in pharmaceutical formulations and biological fluids, using a tris(2,2′-bipyridyl) ruthenium(II)-peroxydisulphate chemiluminescence system in a two-chip device
AU - Al Lawati, Haider A J
AU - Varma, Gouri B.
AU - Suliman, Fakhr Eldin O
PY - 2013/1
Y1 - 2013/1
N2 - A simple, rapid and sensitive chemiluminescent (CL) method for the assay of venlafaxine (VEN) in pharmaceutical formulations and serum samples by a two-chip device is proposed. The method is based on the reaction of this drug with a tris(2,2′-bipyridyl) ruthenium(II)-peroxydisulphate CL system. The optimum chemical conditions for CL emission were investigated. The calibration graph was linear for the concentration range 0.02-8.0 μg/mL. The detection and quantification limits were found to be 0.006 and 0.018 μg/mL, respectively, while the relative standard deviation (RSD) was
AB - A simple, rapid and sensitive chemiluminescent (CL) method for the assay of venlafaxine (VEN) in pharmaceutical formulations and serum samples by a two-chip device is proposed. The method is based on the reaction of this drug with a tris(2,2′-bipyridyl) ruthenium(II)-peroxydisulphate CL system. The optimum chemical conditions for CL emission were investigated. The calibration graph was linear for the concentration range 0.02-8.0 μg/mL. The detection and quantification limits were found to be 0.006 and 0.018 μg/mL, respectively, while the relative standard deviation (RSD) was
KW - chemiluminescence
KW - microfluidics
KW - Tris(2,2′-bipyridyl) ruthenium(II)
KW - two-chip device
KW - venlafaxine
UR - http://www.scopus.com/inward/record.url?scp=84873458133&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84873458133&partnerID=8YFLogxK
U2 - 10.1002/bio.2334
DO - 10.1002/bio.2334
M3 - Article
VL - 28
SP - 44
EP - 49
JO - Luminescence
JF - Luminescence
SN - 1522-7235
IS - 1
ER -