High-throughput method for the analysis of venlafaxine in pharmaceutical formulations and biological fluids, using a tris(2,2′-bipyridyl) ruthenium(II)-peroxydisulphate chemiluminescence system in a two-chip device

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Abstract

A simple, rapid and sensitive chemiluminescent (CL) method for the assay of venlafaxine (VEN) in pharmaceutical formulations and serum samples by a two-chip device is proposed. The method is based on the reaction of this drug with a tris(2,2′-bipyridyl) ruthenium(II)-peroxydisulphate CL system. The optimum chemical conditions for CL emission were investigated. The calibration graph was linear for the concentration range 0.02-8.0 μg/mL. The detection and quantification limits were found to be 0.006 and 0.018 μg/mL, respectively, while the relative standard deviation (RSD) was

Original languageEnglish
Pages (from-to)44-49
Number of pages6
JournalLuminescence
Volume28
Issue number1
DOIs
Publication statusPublished - Jan 2013

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2,2'-Dipyridyl
Drug Compounding
Chemiluminescence
Ruthenium
Luminescence
Throughput
Luminescent Measurements
Equipment and Supplies
Fluids
Pharmaceutical Preparations
Calibration
Limit of Detection
Assays
Serum
Venlafaxine Hydrochloride

Keywords

  • chemiluminescence
  • microfluidics
  • Tris(2,2′-bipyridyl) ruthenium(II)
  • two-chip device
  • venlafaxine

ASJC Scopus subject areas

  • Biophysics
  • Chemistry (miscellaneous)
  • Medicine(all)

Cite this

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abstract = "A simple, rapid and sensitive chemiluminescent (CL) method for the assay of venlafaxine (VEN) in pharmaceutical formulations and serum samples by a two-chip device is proposed. The method is based on the reaction of this drug with a tris(2,2′-bipyridyl) ruthenium(II)-peroxydisulphate CL system. The optimum chemical conditions for CL emission were investigated. The calibration graph was linear for the concentration range 0.02-8.0 μg/mL. The detection and quantification limits were found to be 0.006 and 0.018 μg/mL, respectively, while the relative standard deviation (RSD) was",
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AU - Varma, Gouri B.

AU - Suliman, Fakhr Eldin O

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