High-throughput method for the analysis of venlafaxine in pharmaceutical formulations and biological fluids, using a tris(2,2′-bipyridyl) ruthenium(II)-peroxydisulphate chemiluminescence system in a two-chip device

Haider A J Al Lawati; Gouri B. Varma; Fakhr Eldin O Suliman

doi:10.1002/bio.2334

High-throughput method for the analysis of venlafaxine in pharmaceutical formulations and biological fluids, using a tris(2,2′-bipyridyl) ruthenium(II)-peroxydisulphate chemiluminescence system in a two-chip device

Haider A J Al Lawati^*, Gouri B. Varma, Fakhr Eldin O Suliman

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

A simple, rapid and sensitive chemiluminescent (CL) method for the assay of venlafaxine (VEN) in pharmaceutical formulations and serum samples by a two-chip device is proposed. The method is based on the reaction of this drug with a tris(2,2′-bipyridyl) ruthenium(II)-peroxydisulphate CL system. The optimum chemical conditions for CL emission were investigated. The calibration graph was linear for the concentration range 0.02-8.0 μg/mL. The detection and quantification limits were found to be 0.006 and 0.018 μg/mL, respectively, while the relative standard deviation (RSD) was

Original language	English
Pages (from-to)	44-49
Number of pages	6
Journal	Luminescence
Volume	28
Issue number	1
DOIs	https://doi.org/10.1002/bio.2334
Publication status	Published - Jan 2013

Keywords

chemiluminescence
microfluidics
Tris(2,2′-bipyridyl) ruthenium(II)
two-chip device
venlafaxine

ASJC Scopus subject areas

Biophysics
Chemistry (miscellaneous)
Medicine(all)

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High-throughput method for the analysis of venlafaxine in pharmaceutical formulations and biological fluids, using a tris(2,2′-bipyridyl) ruthenium(II)-peroxydisulphate chemiluminescence system in a two-chip device. / Al Lawati, Haider A J; Varma, Gouri B.; Suliman, Fakhr Eldin O.

In: Luminescence, Vol. 28, No. 1, 01.2013, p. 44-49.

Research output: Contribution to journal › Article › peer-review

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abstract = "A simple, rapid and sensitive chemiluminescent (CL) method for the assay of venlafaxine (VEN) in pharmaceutical formulations and serum samples by a two-chip device is proposed. The method is based on the reaction of this drug with a tris(2,2′-bipyridyl) ruthenium(II)-peroxydisulphate CL system. The optimum chemical conditions for CL emission were investigated. The calibration graph was linear for the concentration range 0.02-8.0 μg/mL. The detection and quantification limits were found to be 0.006 and 0.018 μg/mL, respectively, while the relative standard deviation (RSD) was ",

keywords = "chemiluminescence, microfluidics, Tris(2,2′-bipyridyl) ruthenium(II), two-chip device, venlafaxine",

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High-throughput method for the analysis of venlafaxine in pharmaceutical formulations and biological fluids, using a tris(2,2′-bipyridyl) ruthenium(II)-peroxydisulphate chemiluminescence system in a two-chip device

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Keywords

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