High-level chloroquine resistance in Sudanese isolates of Plasmodium falciparum is associated with mutations in the chloroquine resistance transporter gene pfcrt and the multidrug resistance gene pfmdr1

H. A. Babiker*, S. J. Pringle, A. Abdel-Muhsin, M. Mackinnon, P. Hunt, D. Walliker

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

200 Citations (Scopus)

Abstract

Polymorphisms were examined in 2 Plasmodium falciparum genes, as were chloroquine responses of clones and isolates from a village in eastern Sudan. There was a significant association between an allele of the P. falciparum chloroquine resistance transporter gene (pfcrt-T76) and both in vitro and in vivo resistance. There was a less significant association with the multidrug resistance genepfmdr1-Y86 allele. A significant association between pfmdr1-Y86 and pfcrt-T76 was apparent among resistant isolates, which suggests a joint action of the 2 genes in high-level chloroquine resistance.

Original languageEnglish
Pages (from-to)1535-1538
Number of pages4
JournalJournal of Infectious Diseases
Volume183
Issue number10
DOIs
Publication statusPublished - May 15 2001

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

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