High-level chloroquine resistance in Sudanese isolates of Plasmodium falciparum is associated with mutations in the chloroquine resistance transporter gene pfcrt and the multidrug resistance gene pfmdr1

H. A. Babiker, S. J. Pringle, A. Abdel-Muhsin, M. Mackinnon, P. Hunt, D. Walliker

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Abstract

Polymorphisms were examined in 2 Plasmodium falciparum genes, as were chloroquine responses of clones and isolates from a village in eastern Sudan. There was a significant association between an allele of the P. falciparum chloroquine resistance transporter gene (pfcrt-T76) and both in vitro and in vivo resistance. There was a less significant association with the multidrug resistance genepfmdr1-Y86 allele. A significant association between pfmdr1-Y86 and pfcrt-T76 was apparent among resistant isolates, which suggests a joint action of the 2 genes in high-level chloroquine resistance.

Original languageEnglish
Pages (from-to)1535-1538
Number of pages4
JournalJournal of Infectious Diseases
Volume183
Issue number10
DOIs
Publication statusPublished - May 15 2001

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ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

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