Hemoglobin F as a predictor of health-related quality of life in children with sickle cell anemia

Mohamed Boulassel, Amira Al-Badi, Mohamed Elshinawy, Juhaina Al-Hinai, Muna Al Saadoon, Zahra Al-Qarni, Hammad Khan, Rizwan Nabi Qureshi, Yasser Wali

Research output: Contribution to journalArticle

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Abstract

Purpose: As treatment options for children with sickle cell anemia (SCA) continue to expand survival, evaluation of factors associated with health-related quality of life (HRQoL) is becoming an important aspect for further improving clinical management. Although the general features of SCA are similar, factors influencing HRQoL within a country may differ from those of other countries, therefore this study aimed to explore factors affecting HRQoL in children with SCA living in the Sultanate of Oman. Methods: This was a cross-sectional study in which the PedsQL™ Sickle Cell Disease Module was used to evaluate the overall HRQoL in children with SCA. The socio-demographic data, clinical, and treatment outcomes were collected. Univariate and multivariate linear regression analyses were used to identify predictors of HRQoL. Results: A total of 123 children with SCA, aged from 2 to 16 years were enrolled. The mean total HRQoL score was 52 ± 15% (9–94), where Worry II scale recorded the highest score. The multiple regression analysis revealed that the only predictors of total HRQoL score were hemoglobin F (B = 0.64, 95% confidence interval [CI] 0.149–1.118, P = 0.009) and to a lesser degree white blood cell count (B = − 0.99, 95% CI − 1.761 to − 0.198, P = 0.01), independently of other study parameters such as age, gender, spleen status, and hydroxyurea therapy. Conclusions: Collectively, these findings indicated that hemoglobin F out-weighted white blood cell count in predicting HRQoL in Omani children with SCA. Recognition of these factors could help health professionals to develop effective strategies to improve the overall HRQoL in these young patients.

Original languageEnglish
JournalQuality of Life Research
DOIs
Publication statusAccepted/In press - Jan 1 2018

Fingerprint

Fetal Hemoglobin
Sickle Cell Anemia
Quality of Life
Leukocyte Count
Regression Analysis
Confidence Intervals
Oman
Hydroxyurea
Linear Models
Spleen
Cross-Sectional Studies
Demography

Keywords

  • Hemoglobin F
  • Predictor
  • Quality of life
  • Sickle cell anemia

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Hemoglobin F as a predictor of health-related quality of life in children with sickle cell anemia. / Boulassel, Mohamed; Al-Badi, Amira; Elshinawy, Mohamed; Al-Hinai, Juhaina; Al Saadoon, Muna; Al-Qarni, Zahra; Khan, Hammad; Qureshi, Rizwan Nabi; Wali, Yasser.

In: Quality of Life Research, 01.01.2018.

Research output: Contribution to journalArticle

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abstract = "Purpose: As treatment options for children with sickle cell anemia (SCA) continue to expand survival, evaluation of factors associated with health-related quality of life (HRQoL) is becoming an important aspect for further improving clinical management. Although the general features of SCA are similar, factors influencing HRQoL within a country may differ from those of other countries, therefore this study aimed to explore factors affecting HRQoL in children with SCA living in the Sultanate of Oman. Methods: This was a cross-sectional study in which the PedsQL™ Sickle Cell Disease Module was used to evaluate the overall HRQoL in children with SCA. The socio-demographic data, clinical, and treatment outcomes were collected. Univariate and multivariate linear regression analyses were used to identify predictors of HRQoL. Results: A total of 123 children with SCA, aged from 2 to 16 years were enrolled. The mean total HRQoL score was 52 ± 15{\%} (9–94), where Worry II scale recorded the highest score. The multiple regression analysis revealed that the only predictors of total HRQoL score were hemoglobin F (B = 0.64, 95{\%} confidence interval [CI] 0.149–1.118, P = 0.009) and to a lesser degree white blood cell count (B = − 0.99, 95{\%} CI − 1.761 to − 0.198, P = 0.01), independently of other study parameters such as age, gender, spleen status, and hydroxyurea therapy. Conclusions: Collectively, these findings indicated that hemoglobin F out-weighted white blood cell count in predicting HRQoL in Omani children with SCA. Recognition of these factors could help health professionals to develop effective strategies to improve the overall HRQoL in these young patients.",
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AU - Boulassel, Mohamed

AU - Al-Badi, Amira

AU - Elshinawy, Mohamed

AU - Al-Hinai, Juhaina

AU - Al Saadoon, Muna

AU - Al-Qarni, Zahra

AU - Khan, Hammad

AU - Qureshi, Rizwan Nabi

AU - Wali, Yasser

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N2 - Purpose: As treatment options for children with sickle cell anemia (SCA) continue to expand survival, evaluation of factors associated with health-related quality of life (HRQoL) is becoming an important aspect for further improving clinical management. Although the general features of SCA are similar, factors influencing HRQoL within a country may differ from those of other countries, therefore this study aimed to explore factors affecting HRQoL in children with SCA living in the Sultanate of Oman. Methods: This was a cross-sectional study in which the PedsQL™ Sickle Cell Disease Module was used to evaluate the overall HRQoL in children with SCA. The socio-demographic data, clinical, and treatment outcomes were collected. Univariate and multivariate linear regression analyses were used to identify predictors of HRQoL. Results: A total of 123 children with SCA, aged from 2 to 16 years were enrolled. The mean total HRQoL score was 52 ± 15% (9–94), where Worry II scale recorded the highest score. The multiple regression analysis revealed that the only predictors of total HRQoL score were hemoglobin F (B = 0.64, 95% confidence interval [CI] 0.149–1.118, P = 0.009) and to a lesser degree white blood cell count (B = − 0.99, 95% CI − 1.761 to − 0.198, P = 0.01), independently of other study parameters such as age, gender, spleen status, and hydroxyurea therapy. Conclusions: Collectively, these findings indicated that hemoglobin F out-weighted white blood cell count in predicting HRQoL in Omani children with SCA. Recognition of these factors could help health professionals to develop effective strategies to improve the overall HRQoL in these young patients.

AB - Purpose: As treatment options for children with sickle cell anemia (SCA) continue to expand survival, evaluation of factors associated with health-related quality of life (HRQoL) is becoming an important aspect for further improving clinical management. Although the general features of SCA are similar, factors influencing HRQoL within a country may differ from those of other countries, therefore this study aimed to explore factors affecting HRQoL in children with SCA living in the Sultanate of Oman. Methods: This was a cross-sectional study in which the PedsQL™ Sickle Cell Disease Module was used to evaluate the overall HRQoL in children with SCA. The socio-demographic data, clinical, and treatment outcomes were collected. Univariate and multivariate linear regression analyses were used to identify predictors of HRQoL. Results: A total of 123 children with SCA, aged from 2 to 16 years were enrolled. The mean total HRQoL score was 52 ± 15% (9–94), where Worry II scale recorded the highest score. The multiple regression analysis revealed that the only predictors of total HRQoL score were hemoglobin F (B = 0.64, 95% confidence interval [CI] 0.149–1.118, P = 0.009) and to a lesser degree white blood cell count (B = − 0.99, 95% CI − 1.761 to − 0.198, P = 0.01), independently of other study parameters such as age, gender, spleen status, and hydroxyurea therapy. Conclusions: Collectively, these findings indicated that hemoglobin F out-weighted white blood cell count in predicting HRQoL in Omani children with SCA. Recognition of these factors could help health professionals to develop effective strategies to improve the overall HRQoL in these young patients.

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