Haemostatic parameters in patients with Behçet's disease

Juma K. Alkaabi, David Gravell, Hamood Al-Haddabi, Anil Pathare

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objectives: This study aimed to evaluate the cause of thrombosis in Behçet's disease (BD) patients, since abnormalities in coagulation and fibrinolytic parameters have shown contradictory results. Methods: Haemostatic parameters were retrospectively evaluated in BD patients treated between January 2007 and January 2011 at Sultan Qaboos University Hospital, Oman. Te blood samples of 35 Omani BD patients and 30 healthy controls were analysed for factor VIII:C levels, activated protein C resistance (APCR), von Willebrand factor (vWF) antigens (Ag), collagen binding and ristocetin co-factor activity (RiCoF), antithrombin (AT), protein C (chromogenic and clotting), protein S, homocysteine, tissue plasminogen activator, plasminogen activator inhibitor, plasminogen, alpha 2-antiplasmin, lupus anticoagulant and anticardiolipin and beta2-glycoprotein-1 antibodies. Results: The mean values of factor VIII:C, vWF Ag, AT and protein S were significantly higher in the patient group (P = 0.01, 0.006, 0.04 and 0.01, respectively). There was no deficiency in protein C. Screening for APCR, anticardiolipin antibodies, anti-beta2-glycoprotein-1 antibodies and lupus anticoagulant was negative and there were no differences in homocysteine levels, nor were there differences between patients with and without thrombosis. Six patients had elevated factor VIII:C levels (>150 IU/dL, P

Original languageEnglish
JournalSultan Qaboos University Medical Journal
Volume14
Issue number2
Publication statusPublished - 2014

Fingerprint

Hemostatics
Antithrombin Proteins
Activated Protein C Resistance
Lupus Coagulation Inhibitor
Protein S
Factor VIII
von Willebrand Factor
Homocysteine
Glycoproteins
Thrombosis
alpha-2-Antiplasmin
Oman
Protein C Deficiency
Ristocetin
Plasminogen Inactivators
Anticardiolipin Antibodies
Antibodies
Plasminogen
Tissue Plasminogen Activator
Protein C

Keywords

  • Behcet syndrome
  • Blood vessels
  • Hemostasis
  • Oman
  • Trombosis
  • Vasculitis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Haemostatic parameters in patients with Behçet's disease. / Alkaabi, Juma K.; Gravell, David; Al-Haddabi, Hamood; Pathare, Anil.

In: Sultan Qaboos University Medical Journal, Vol. 14, No. 2, 2014.

Research output: Contribution to journalArticle

Alkaabi, Juma K. ; Gravell, David ; Al-Haddabi, Hamood ; Pathare, Anil. / Haemostatic parameters in patients with Behçet's disease. In: Sultan Qaboos University Medical Journal. 2014 ; Vol. 14, No. 2.
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