Haemorrhagic disease of lagomorphs

evidence for a calicivirus

A. Moussa, D. Chasey, A. Lavazza, L. Capucci, B. Šmid, G. Meyers, C. Rossi, H. J. Thiel, R. Vlásak, L. Rønsholt, N. Nowotny, K. McCullough, D. Gavier-Widen

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Studies on the aetiological agents of rabbit haemorrhagic disease (RHD) and European brown hare syndrome show that the viruses responsible for these infections can be placed in the family Caliciviridae. Established members of this group are vesicular exanthema virus (prototype), San Miguel sea lion virus and feline calicivirus. The human hepatitis E virus and the Norwalk agent may soon be included. The RHD virus genome consists of a positive stranded RNA molecule composed of 7437 nucleotides. A major subgenomic RNA of 2.2 kb, colinear with the 3′ end of the genomic RNA, can also be recovered from infected liver tissue, and both RNAs are enclosed within viral capsids formed by a single major protein of approximately 60 kDa. Electron microscopic examination of organ suspensions from diseased animals shows two types of particle; 35-40 nm complete virions have the regularly arranged cup-shaped depressions typical of calicivirus morphology, and 23-25 nm smooth particles resulting from degradation of the outer surface structures of the complete virions.

Original languageEnglish
Pages (from-to)375-381
Number of pages7
JournalVeterinary Microbiology
Volume33
Issue number1-4
DOIs
Publication statusPublished - 1992

Fingerprint

Vesivirus
Lagomorpha
RNA
virion
Virion
Vesicular exanthema of swine virus
vesicular exanthema of swine
Caliciviridae
Rabbit Haemorrhagic Disease Virus
Norwalk virus
Feline Calicivirus
Rabbit hemorrhagic disease virus
Hepatitis E virus
Hares
Feline calicivirus
viruses
Animal Diseases
capsid
Capsid
etiological agents

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Microbiology
  • veterinary(all)

Cite this

Moussa, A., Chasey, D., Lavazza, A., Capucci, L., Šmid, B., Meyers, G., ... Gavier-Widen, D. (1992). Haemorrhagic disease of lagomorphs: evidence for a calicivirus. Veterinary Microbiology, 33(1-4), 375-381. https://doi.org/10.1016/0378-1135(92)90065-2

Haemorrhagic disease of lagomorphs : evidence for a calicivirus. / Moussa, A.; Chasey, D.; Lavazza, A.; Capucci, L.; Šmid, B.; Meyers, G.; Rossi, C.; Thiel, H. J.; Vlásak, R.; Rønsholt, L.; Nowotny, N.; McCullough, K.; Gavier-Widen, D.

In: Veterinary Microbiology, Vol. 33, No. 1-4, 1992, p. 375-381.

Research output: Contribution to journalArticle

Moussa, A, Chasey, D, Lavazza, A, Capucci, L, Šmid, B, Meyers, G, Rossi, C, Thiel, HJ, Vlásak, R, Rønsholt, L, Nowotny, N, McCullough, K & Gavier-Widen, D 1992, 'Haemorrhagic disease of lagomorphs: evidence for a calicivirus', Veterinary Microbiology, vol. 33, no. 1-4, pp. 375-381. https://doi.org/10.1016/0378-1135(92)90065-2
Moussa A, Chasey D, Lavazza A, Capucci L, Šmid B, Meyers G et al. Haemorrhagic disease of lagomorphs: evidence for a calicivirus. Veterinary Microbiology. 1992;33(1-4):375-381. https://doi.org/10.1016/0378-1135(92)90065-2
Moussa, A. ; Chasey, D. ; Lavazza, A. ; Capucci, L. ; Šmid, B. ; Meyers, G. ; Rossi, C. ; Thiel, H. J. ; Vlásak, R. ; Rønsholt, L. ; Nowotny, N. ; McCullough, K. ; Gavier-Widen, D. / Haemorrhagic disease of lagomorphs : evidence for a calicivirus. In: Veterinary Microbiology. 1992 ; Vol. 33, No. 1-4. pp. 375-381.
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