TY - JOUR
T1 - Glucometabolic Perturbations in Type 2 Diabetes Mellitus and Coronavirus Disease 2019: Causes, Consequences, and How to Counter Them Using Novel Antidiabetic Drugs – The CAPISCO International Expert Panel
T2 - Causes, Consequences, and How to Counter Them Using Novel Antidiabetic Drugs – The CAPISCO International Expert Panel
AU - Popovic, Djordje S.
AU - Papanas, Nikolaos
AU - Koufakis, Theocharis
AU - Kotsa, Kalliopi
AU - Al Mahmeed, Wael
AU - Al-Rasadi, Khalid
AU - Al-Alawi, Kamila
AU - Banach, Maciej
AU - Banerjee, Yajnavalka
AU - Ceriello, Antonio
AU - Cesur, Mustafa
AU - Cosentino, Francesco
AU - Firenze, Alberto
AU - Galia, Massimo
AU - Goh, Su Yen
AU - Janez, Andrej
AU - Kalra, Sanjay
AU - Kempler, Peter
AU - Kapoor, Nitin
AU - Lessan, Nader
AU - Lotufo, Paulo
AU - Rizvi, Ali A.
AU - Sahebkar, Amirhossein
AU - Santos, Raul D.
AU - Stoian, Anca Pantea
AU - Toth, Peter P.
AU - Viswanathan, Vijay
AU - Rizzo, Manfredi
N1 - Thieme. All rights reserved.
Publisher Copyright:
© 2023. Thieme. All rights reserved.
PY - 2023/5
Y1 - 2023/5
N2 - The growing amount of evidence suggests the existence of a bidirectional relation between coronavirus disease 2019 (COV-ID-19) and type 2 diabetes mellitus (T2DM), as these two conditions exacerbate each other, causing a significant healthcare and socioeconomic burden. The alterations in innate and adaptive cellular immunity, adipose tissue, alveolar and endothelial dysfunction, hypercoagulation, the propensity to an increased viral load, and chronic diabetic complications are all associated with glucometabolic perturbations of T2DM patients that predispose them to severe forms of COVID-19 and mortality. Severe acute respiratory syndrome coronavirus 2 infection negatively impacts glucose homeostasis due to its effects on insulin sensitivity and β-cell function, further aggravating the preexisting glucometabolic perturbations in individuals with T2DM. Thus, the most effective ways are urgently needed for countering these glucometabolic disturbances occurring during acute COVID-19 illness in T2DM patients. The novel classes of antidiabetic medications (dipeptidyl peptidase 4 inhibitors (DPP-4is), glucagon-like peptide-1 receptor agonists (GLP-1 RAs), and sodium-glucose co-transporter-2 inhibitors (SGLT-2is) are considered candidate drugs for this purpose. This review article summarizes current knowledge regarding glucometabolic disturbances during acute COVID-19 illness in T2DM patients and the potential ways to tackle them using novel antidiabetic medications. Recent observational data suggest that preadmission use of GLP-1 RAs and SGLT-2is are associated with decreased patient mortality, while DPP-4is is associated with increased in-hospital mortality of T2DM patients with COVID-19. Although these results provide further evidence for the widespread use of these two classes of medications in this COVID-19 era, dedicated randomized controlled trials analyzing the effects of in-hospital use of novel antidiabetic agents in T2DM patients with COVID-19 are needed.
AB - The growing amount of evidence suggests the existence of a bidirectional relation between coronavirus disease 2019 (COV-ID-19) and type 2 diabetes mellitus (T2DM), as these two conditions exacerbate each other, causing a significant healthcare and socioeconomic burden. The alterations in innate and adaptive cellular immunity, adipose tissue, alveolar and endothelial dysfunction, hypercoagulation, the propensity to an increased viral load, and chronic diabetic complications are all associated with glucometabolic perturbations of T2DM patients that predispose them to severe forms of COVID-19 and mortality. Severe acute respiratory syndrome coronavirus 2 infection negatively impacts glucose homeostasis due to its effects on insulin sensitivity and β-cell function, further aggravating the preexisting glucometabolic perturbations in individuals with T2DM. Thus, the most effective ways are urgently needed for countering these glucometabolic disturbances occurring during acute COVID-19 illness in T2DM patients. The novel classes of antidiabetic medications (dipeptidyl peptidase 4 inhibitors (DPP-4is), glucagon-like peptide-1 receptor agonists (GLP-1 RAs), and sodium-glucose co-transporter-2 inhibitors (SGLT-2is) are considered candidate drugs for this purpose. This review article summarizes current knowledge regarding glucometabolic disturbances during acute COVID-19 illness in T2DM patients and the potential ways to tackle them using novel antidiabetic medications. Recent observational data suggest that preadmission use of GLP-1 RAs and SGLT-2is are associated with decreased patient mortality, while DPP-4is is associated with increased in-hospital mortality of T2DM patients with COVID-19. Although these results provide further evidence for the widespread use of these two classes of medications in this COVID-19 era, dedicated randomized controlled trials analyzing the effects of in-hospital use of novel antidiabetic agents in T2DM patients with COVID-19 are needed.
KW - glucagon-like peptide-1 receptor agonist
KW - coronavirus disease 2019
KW - sodium-glucose co-transporter-2 inhibitor
KW - type 2 diabetes mellitus
KW - dipeptidyl peptidase 4 inhibitor
KW - COVID-19/complications
KW - Humans
KW - Glucose
KW - Sodium-Glucose Transporter 2 Inhibitors/therapeutic use
KW - Diabetes Mellitus, Type 2/complications
KW - Glucagon-Like Peptide 1/therapeutic use
KW - Hypoglycemic Agents/pharmacology
KW - Dipeptidyl-Peptidase IV Inhibitors/therapeutic use
UR - http://www.scopus.com/inward/record.url?scp=85153756990&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85153756990&partnerID=8YFLogxK
U2 - 10.1055/a-2019-1111
DO - 10.1055/a-2019-1111
M3 - Review article
C2 - 36693416
SN - 0947-7349
VL - 131
SP - 260
EP - 267
JO - Experimental and Clinical Endocrinology and Diabetes
JF - Experimental and Clinical Endocrinology and Diabetes
IS - 5
ER -