Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function

María Soler Artigas; Daan W. Loth; Louise V. Wain; Sina A. Gharib; Ma'En Obeidat; Wenbo Tang; Guangju Zhai; Jing Hua Zhao; Albert Vernon Smith; Jennifer E. Huffman; Eva Albrecht; Catherine M. Jackson; David M. Evans; Gemma Cadby; Myriam Fornage; Ani Manichaikul; Lorna M. Lopez; Toby Johnson; Melinda C. Aldrich; Thor Aspelund; Ins Barroso; Harry Campbell; Patricia A. Cassano; David J. Couper; Gudny Eiriksdottir; Nora Franceschini; Melissa Garcia; Christian Gieger; Gauti Kjartan Gislason; Ivica Grkovic; Christopher J. Hammond; Dana B. Hancock; Tamara B. Harris; Adaikalavan Ramasamy; Susan R. Heckbert; Markku Heliövaara; Georg Homuth; Pirro G. Hysi; Alan L. James; Stipan Jankovic; Bonnie R. Joubert; Stefan Karrasch; Norman Klopp; Beate Koch; Stephen B. Kritchevsky; Lenore J. Launer; Yongmei Liu; Laura R. Loehr; Kurt Lohman; Ruth J.F. Loos; Thomas Lumley; Khalid A. Al Balushi; Wei Q. Ang; R. Graham Barr; John Beilby; John D. Blakey; Mladen Boban; Vesna Boraska; Jonas Brisman; John R. Britton; Guy G. Brusselle; Cyrus Cooper; Ivan Curjuric; Santosh Dahgam; Ian J. Deary; Shah Ebrahim; Mark Eijgelsheim; Clyde Francks; Darya Gaysina; Raquel Granell; Xiangjun Gu; John L. Hankinson; Rebecca Hardy; Sarah E. Harris; John Henderson; Amanda Henry; Aroon D. Hingorani; Albert Hofman; Patrick G. Holt; Jennie Hui; Michael L. Hunter; Medea Imboden; Karen A. Jameson; Shona M. Kerr; Ivana Kolcic; Florian Kronenberg; Jason Z. Liu; Jonathan Marchini; Tricia McKeever; Andrew D. Morris; Anna Carin Olin; David J. Porteous; Dirkje S. Postma; Stephen S. Rich; Susan M. Ring; Fernando Rivadeneira; Thierry Rochat; Avan Aihie Sayer; Ian Sayers; Peter D. Sly; George Davey Smith; Akshay Sood; John M. Starr; André G. Uitterlinden; Judith M. Vonk; S. Goya Wannamethee; Peter H. Whincup; Cisca Wijmenga; O. Dale Williams; Andrew Wong; Massimo Mangino; Kristin D. Marciante; Wendy L. McArdle; Bernd Meibohm; Alanna C. Morrison; Kari E. North; Ernst Omenaas; Lyle J. Palmer; Kirsi H. Pietiläinen; Isabelle Pin; Ozren Polašek; Anneli Pouta; Bruce M. Psaty; Anna Liisa Hartikainen; Taina Rantanen; Samuli Ripatti; Jerome I. Rotter; Igor Rudan; Alicja R. Rudnicka; Holger Schulz; So Youn Shin; Tim D. Spector; Ida Surakka; Veronique Vitart; Henry Völzke; Nicholas J. Wareham; Nicole M. Warrington; H. Erich Wichmann; Sarah H. Wild; Jemma B. Wilk; Matthias Wjst; Alan F. Wright; Lina Zgaga; Tatijana Zemunik; Craig E. Pennell; Fredrik Nyberg; Diana Kuh; John W. Holloway; H. Marike Boezen; Debbie A. Lawlor; Richard W. Morris; Nicole Probst-Hensch; Jaakko Kaprio; James F. Wilson; Caroline Hayward; Mika Kähönen; Joachim Heinrich; Arthur W. Musk; Deborah L. Jarvis; Sven Gläser; Marjo Riitta Järvelin; Bruno H. Ch Stricker; Paul Elliott; George T. O'Connor; David P. Strachan; Stephanie J. London; Ian P. Hall; Vilmundur Gudnason; Martin D. Tobin

doi:10.1038/ng.941

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function

María Soler Artigas, Daan W. Loth, Louise V. Wain, Sina A. Gharib, Ma'En Obeidat, Wenbo Tang, Guangju Zhai, Jing Hua Zhao, Albert Vernon Smith, Jennifer E. Huffman, Eva Albrecht, Catherine M. Jackson, David M. Evans, Gemma Cadby, Myriam Fornage, Ani Manichaikul, Lorna M. Lopez, Toby Johnson, Melinda C. Aldrich, Thor AspelundIns Barroso, Harry Campbell, Patricia A. Cassano, David J. Couper, Gudny Eiriksdottir, Nora Franceschini, Melissa Garcia, Christian Gieger, Gauti Kjartan Gislason, Ivica Grkovic, Christopher J. Hammond, Dana B. Hancock, Tamara B. Harris, Adaikalavan Ramasamy, Susan R. Heckbert, Markku Heliövaara, Georg Homuth, Pirro G. Hysi, Alan L. James, Stipan Jankovic, Bonnie R. Joubert, Stefan Karrasch, Norman Klopp, Beate Koch, Stephen B. Kritchevsky, Lenore J. Launer, Yongmei Liu, Laura R. Loehr, Kurt Lohman, Ruth J.F. Loos, Thomas Lumley, Khalid A. Al Balushi, Wei Q. Ang, R. Graham Barr, John Beilby, John D. Blakey, Mladen Boban, Vesna Boraska, Jonas Brisman, John R. Britton, Guy G. Brusselle, Cyrus Cooper, Ivan Curjuric, Santosh Dahgam, Ian J. Deary, Shah Ebrahim, Mark Eijgelsheim, Clyde Francks, Darya Gaysina, Raquel Granell, Xiangjun Gu, John L. Hankinson, Rebecca Hardy, Sarah E. Harris, John Henderson, Amanda Henry, Aroon D. Hingorani, Albert Hofman, Patrick G. Holt, Jennie Hui, Michael L. Hunter, Medea Imboden, Karen A. Jameson, Shona M. Kerr, Ivana Kolcic, Florian Kronenberg, Jason Z. Liu, Jonathan Marchini, Tricia McKeever, Andrew D. Morris, Anna Carin Olin, David J. Porteous, Dirkje S. Postma, Stephen S. Rich, Susan M. Ring, Fernando Rivadeneira, Thierry Rochat, Avan Aihie Sayer, Ian Sayers, Peter D. Sly, George Davey Smith, Akshay Sood, John M. Starr, André G. Uitterlinden, Judith M. Vonk, S. Goya Wannamethee, Peter H. Whincup, Cisca Wijmenga, O. Dale Williams, Andrew Wong, Massimo Mangino, Kristin D. Marciante, Wendy L. McArdle, Bernd Meibohm, Alanna C. Morrison, Kari E. North, Ernst Omenaas, Lyle J. Palmer, Kirsi H. Pietiläinen, Isabelle Pin, Ozren Polašek, Anneli Pouta, Bruce M. Psaty, Anna Liisa Hartikainen, Taina Rantanen, Samuli Ripatti, Jerome I. Rotter, Igor Rudan, Alicja R. Rudnicka, Holger Schulz, So Youn Shin, Tim D. Spector, Ida Surakka, Veronique Vitart, Henry Völzke, Nicholas J. Wareham, Nicole M. Warrington, H. Erich Wichmann, Sarah H. Wild, Jemma B. Wilk, Matthias Wjst, Alan F. Wright, Lina Zgaga, Tatijana Zemunik, Craig E. Pennell, Fredrik Nyberg, Diana Kuh, John W. Holloway, H. Marike Boezen, Debbie A. Lawlor, Richard W. Morris, Nicole Probst-Hensch, Jaakko Kaprio, James F. Wilson, Caroline Hayward, Mika Kähönen, Joachim Heinrich, Arthur W. Musk, Deborah L. Jarvis, Sven Gläser, Marjo Riitta Järvelin, Bruno H. Ch Stricker, Paul Elliott, George T. O'Connor, David P. Strachan, Stephanie J. London, Ian P. Hall, Vilmundur Gudnason, Martin D. Tobin^*

^*Corresponding author for this work

Pharmacology & Clinical Pharmacy

Research output: Contribution to journal › Article › peer-review

321 Citations (Scopus)

Abstract

Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P < 5 ×-10^-8) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function.

Original language	English
Pages (from-to)	1082-1090
Number of pages	9
Journal	Nature Genetics
Volume	43
Issue number	11
DOIs	https://doi.org/10.1038/ng.941
Publication status	Published - Nov 2011

ASJC Scopus subject areas

Genetics

Access to Document

10.1038/ng.941

Cite this

Artigas, M. S., Loth, D. W., Wain, L. V., Gharib, S. A., Obeidat, ME., Tang, W., Zhai, G., Zhao, J. H., Smith, A. V., Huffman, J. E., Albrecht, E., Jackson, C. M., Evans, D. M., Cadby, G., Fornage, M., Manichaikul, A., Lopez, L. M., Johnson, T., Aldrich, M. C., ... Tobin, M. D. (2011). Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nature Genetics, 43(11), 1082-1090. https://doi.org/10.1038/ng.941

Artigas, MS, Loth, DW, Wain, LV, Gharib, SA, Obeidat, ME, Tang, W, Zhai, G, Zhao, JH, Smith, AV, Huffman, JE, Albrecht, E, Jackson, CM, Evans, DM, Cadby, G, Fornage, M, Manichaikul, A, Lopez, LM, Johnson, T, Aldrich, MC, Aspelund, T, Barroso, I, Campbell, H, Cassano, PA, Couper, DJ, Eiriksdottir, G, Franceschini, N, Garcia, M, Gieger, C, Gislason, GK, Grkovic, I, Hammond, CJ, Hancock, DB, Harris, TB, Ramasamy, A, Heckbert, SR, Heliövaara, M, Homuth, G, Hysi, PG, James, AL, Jankovic, S, Joubert, BR, Karrasch, S, Klopp, N, Koch, B, Kritchevsky, SB, Launer, LJ, Liu, Y, Loehr, LR, Lohman, K, Loos, RJF, Lumley, T, Al Balushi, KA, Ang, WQ, Barr, RG, Beilby, J, Blakey, JD, Boban, M, Boraska, V, Brisman, J, Britton, JR, Brusselle, GG, Cooper, C, Curjuric, I, Dahgam, S, Deary, IJ, Ebrahim, S, Eijgelsheim, M, Francks, C, Gaysina, D, Granell, R, Gu, X, Hankinson, JL, Hardy, R, Harris, SE, Henderson, J, Henry, A, Hingorani, AD, Hofman, A, Holt, PG, Hui, J, Hunter, ML, Imboden, M, Jameson, KA, Kerr, SM, Kolcic, I, Kronenberg, F, Liu, JZ, Marchini, J, McKeever, T, Morris, AD, Olin, AC, Porteous, DJ, Postma, DS, Rich, SS, Ring, SM, Rivadeneira, F, Rochat, T, Sayer, AA, Sayers, I, Sly, PD, Smith, GD, Sood, A, Starr, JM, Uitterlinden, AG, Vonk, JM, Wannamethee, SG, Whincup, PH, Wijmenga, C, Williams, OD, Wong, A, Mangino, M, Marciante, KD, McArdle, WL, Meibohm, B, Morrison, AC, North, KE, Omenaas, E, Palmer, LJ, Pietiläinen, KH, Pin, I, Polašek, O, Pouta, A, Psaty, BM, Hartikainen, AL, Rantanen, T, Ripatti, S, Rotter, JI, Rudan, I, Rudnicka, AR, Schulz, H, Shin, SY, Spector, TD, Surakka, I, Vitart, V, Völzke, H, Wareham, NJ, Warrington, NM, Wichmann, HE, Wild, SH, Wilk, JB, Wjst, M, Wright, AF, Zgaga, L, Zemunik, T, Pennell, CE, Nyberg, F, Kuh, D, Holloway, JW, Boezen, HM, Lawlor, DA, Morris, RW, Probst-Hensch, N, Kaprio, J, Wilson, JF, Hayward, C, Kähönen, M, Heinrich, J, Musk, AW, Jarvis, DL, Gläser, S, Järvelin, MR, Ch Stricker, BH, Elliott, P, O'Connor, GT, Strachan, DP, London, SJ, Hall, IP, Gudnason, V & Tobin, MD 2011, 'Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function', Nature Genetics, vol. 43, no. 11, pp. 1082-1090. https://doi.org/10.1038/ng.941

@article{49ef0741f12f47eebb67ad9346c8129c,

title = "Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function",

abstract = "Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P < 5 ×-10-8) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function.",

author = "Artigas, {Mar{\'i}a Soler} and Loth, {Daan W.} and Wain, {Louise V.} and Gharib, {Sina A.} and Ma'En Obeidat and Wenbo Tang and Guangju Zhai and Zhao, {Jing Hua} and Smith, {Albert Vernon} and Huffman, {Jennifer E.} and Eva Albrecht and Jackson, {Catherine M.} and Evans, {David M.} and Gemma Cadby and Myriam Fornage and Ani Manichaikul and Lopez, {Lorna M.} and Toby Johnson and Aldrich, {Melinda C.} and Thor Aspelund and Ins Barroso and Harry Campbell and Cassano, {Patricia A.} and Couper, {David J.} and Gudny Eiriksdottir and Nora Franceschini and Melissa Garcia and Christian Gieger and Gislason, {Gauti Kjartan} and Ivica Grkovic and Hammond, {Christopher J.} and Hancock, {Dana B.} and Harris, {Tamara B.} and Adaikalavan Ramasamy and Heckbert, {Susan R.} and Markku Heli{\"o}vaara and Georg Homuth and Hysi, {Pirro G.} and James, {Alan L.} and Stipan Jankovic and Joubert, {Bonnie R.} and Stefan Karrasch and Norman Klopp and Beate Koch and Kritchevsky, {Stephen B.} and Launer, {Lenore J.} and Yongmei Liu and Loehr, {Laura R.} and Kurt Lohman and Loos, {Ruth J.F.} and Thomas Lumley and {Al Balushi}, {Khalid A.} and Ang, {Wei Q.} and Barr, {R. Graham} and John Beilby and Blakey, {John D.} and Mladen Boban and Vesna Boraska and Jonas Brisman and Britton, {John R.} and Brusselle, {Guy G.} and Cyrus Cooper and Ivan Curjuric and Santosh Dahgam and Deary, {Ian J.} and Shah Ebrahim and Mark Eijgelsheim and Clyde Francks and Darya Gaysina and Raquel Granell and Xiangjun Gu and Hankinson, {John L.} and Rebecca Hardy and Harris, {Sarah E.} and John Henderson and Amanda Henry and Hingorani, {Aroon D.} and Albert Hofman and Holt, {Patrick G.} and Jennie Hui and Hunter, {Michael L.} and Medea Imboden and Jameson, {Karen A.} and Kerr, {Shona M.} and Ivana Kolcic and Florian Kronenberg and Liu, {Jason Z.} and Jonathan Marchini and Tricia McKeever and Morris, {Andrew D.} and Olin, {Anna Carin} and Porteous, {David J.} and Postma, {Dirkje S.} and Rich, {Stephen S.} and Ring, {Susan M.} and Fernando Rivadeneira and Thierry Rochat and Sayer, {Avan Aihie} and Ian Sayers and Sly, {Peter D.} and Smith, {George Davey} and Akshay Sood and Starr, {John M.} and Uitterlinden, {Andr{\'e} G.} and Vonk, {Judith M.} and Wannamethee, {S. Goya} and Whincup, {Peter H.} and Cisca Wijmenga and Williams, {O. Dale} and Andrew Wong and Massimo Mangino and Marciante, {Kristin D.} and McArdle, {Wendy L.} and Bernd Meibohm and Morrison, {Alanna C.} and North, {Kari E.} and Ernst Omenaas and Palmer, {Lyle J.} and Pietil{\"a}inen, {Kirsi H.} and Isabelle Pin and Ozren Pola{\v s}ek and Anneli Pouta and Psaty, {Bruce M.} and Hartikainen, {Anna Liisa} and Taina Rantanen and Samuli Ripatti and Rotter, {Jerome I.} and Igor Rudan and Rudnicka, {Alicja R.} and Holger Schulz and Shin, {So Youn} and Spector, {Tim D.} and Ida Surakka and Veronique Vitart and Henry V{\"o}lzke and Wareham, {Nicholas J.} and Warrington, {Nicole M.} and Wichmann, {H. Erich} and Wild, {Sarah H.} and Wilk, {Jemma B.} and Matthias Wjst and Wright, {Alan F.} and Lina Zgaga and Tatijana Zemunik and Pennell, {Craig E.} and Fredrik Nyberg and Diana Kuh and Holloway, {John W.} and Boezen, {H. Marike} and Lawlor, {Debbie A.} and Morris, {Richard W.} and Nicole Probst-Hensch and Jaakko Kaprio and Wilson, {James F.} and Caroline Hayward and Mika K{\"a}h{\"o}nen and Joachim Heinrich and Musk, {Arthur W.} and Jarvis, {Deborah L.} and Sven Gl{\"a}ser and J{\"a}rvelin, {Marjo Riitta} and {Ch Stricker}, {Bruno H.} and Paul Elliott and O'Connor, {George T.} and Strachan, {David P.} and London, {Stephanie J.} and Hall, {Ian P.} and Vilmundur Gudnason and Tobin, {Martin D.}",

note = "Funding Information: We thank the many colleagues who contributed to collection and phenotypic characterization of the clinical sampling, genotyping and analysis of the data. We especially thank those who kindly agreed to participate in the studies. Major funding for this work is from the following sources (alphabetical): Academy of Finland (project grants 104781, 120315, 129269, 1114194, Center of Excellence in Complex Disease Genetics (213506 and 129680) and SALVE); Althingi (Icelandic Parliament); Arthritis Research Campaign; Asthma UK; AstraZeneca; AXA Research Fund; Biotechnology and Biological Sciences Research Council (BBSRC) (BB/F019394/1, G20234); British Heart Foundation (PG/97012, PG/06/154/22043, FS05/125); British Lung Foundation; Canadian Institutes of Health Research (Grant ID MOP-82893); Cancer Research United Kingdom; Funding Information: N01-HC-48050, N01-HC-45134, N01-HC-05187, N01-HC-45205, N01-HC-45204, N01 HC-25195, N01-HC-95159 through N01-HC-95169, RR-024156, N02-HL-6-4278, R01 HL-071022, R01 HL-077612, R01 HL-074104, RC1 HL100543, HHSN268201100005C, HHSN268201100006C, HHSN268201100007C, HHSN268201100008C, HHSN268201100009C, HHSN268201100010C, HHSN268201100011C and HHSN268201100012C, grants HL080295, HL087652, HL105756, R01-HL-084099, R01HL087641, R01HL59367, R01HL086694, HL088133, HL075336 5R01HL087679-02 through the STAMPEED program (1RL1MH083268-01), 1K23HL094531-01); US NIH National Institute of Allergy and Infectious Diseases (NIAID); US NIH National Institute of Child Health and Human Development (NICHD); US NIH National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (DK063491); US NIH National Institute of Environmental Health Sciences (NIEHS) (ZO1 ES49019, ES015794); US NIH National Institute of Mental Health (NIMH) (5R01MH63706:02); US NIH National Institute of Neurological Disorders and Stroke (NINDD); US NIH National Institute on Aging (NIA) (R01 AG032098, RC1 AG035835, N01AG12100, N01AG62101, N01AG62103, N01AG62106, 1R01AG032098-01A1, AG-023269, AG-15928, AG-20098, AG-027058); Wellcome Trust (077016/Z/05/Z, GR069224, 068545/Z/02, 076113/B/04/Z, 079895). Funding Information: Chief Scientist Office, Scottish Government Health Directorate (CZD/16/6); Croatian Institute for Public Health; UK Department of Health; Dutch Kidney Foundation; Erasmus Medical Center and Erasmus University, Rotterdam; Estonian Genome Center, University of Tartu, Estonia (SF0180142s08); EU funding (GABRIEL GRANT Number: 018996, ECRHS II Coordination Number: QLK4-CT-1999-01237); European Commission (DG XII, EURO-BLCS, FP-5 QLG1-CT-2000-01643, FP-6 LSHB-CT-2006-018996 (GABRIEL), FP-6 LSHG-CT-2006-018947 (EUROSPAN), FP-6 GenomEUtwin project QLG2-CT-2002-01254, FP7/2007-2013: HEALTH-F2-2008-201865, GEFOS, HEALTH-F2-2008-35627, TREAT-OA, HEALTH-F4-2007-201413 (ENGAGE)); Finnish Foundation for Cardiovascular Research; Flight Attendant Medical Research Institute (FAMRI); German Asthma and COPD Network (COSYCONET: BMBF grant 01GI0883); German Bundesministerium fuer Forschung und Technology (01 AK 803 A-H, 01 IG 07015 G); German Federal Ministry of Education and Research (BMBF) (03ZIK012, 01ZZ9603, 01ZZ0103 and 01ZZ0403): German National Genome Research Network (NGFN-2 and NGFN-plus); German Ministry of Cultural Affairs; GlaxoSmithKline; Gyllenberg Foundations; Healthway, Western Australia; Helmholtz Zentrum M{\"u}nchen, German Research Center for Environmental Health, Neuherberg, Germany; Healthcare and Bioscience iNet (funded by the East Midlands Development Agency, partially financed by the European Regional Development Fund, delivered by Medilink East Midlands); Higher Education Funding Council for England (HEFCE); Hjartavernd (Icelandic Heart Association); Innsbruck Medical University; Institute for Anthropological Research in Zagreb; International Osteoporosis Foundation; Intramural Research Program of the NIH, National Institute on Aging and National Institute of Environmental Health Sciences; Jalmari and Rauha Ahokas Foundation; Juvenile Diabetes Research Foundation International (JDRF); Lifelong Health and Wellbeing Initiative (G0700704/84698); Medical Research Council UK (G1000861, G0501942, G0902313, G0000934, G0800582, G0500539, G0600705, PrevMetSyn/SALVE, G9901462); Medical Research Fund of the Tampere University Hospital; Ministry of Science, Education and Sport of the Republic of Croatia (108-1080315-0302); Medical Research Council Human Genetics Unit; Medisearch–The Leicester Medical Research Foundation; Munich Center of Health Sciences (MC Health) as part of LMUinnovativ; National Health and Medical Research Council of Australia (Grant ID 403981 and ID 003209); National Human Genome Research Institute (NHGRI) (U01-HG-004729, U01-HG-004402); National Institute for Health Research (NIHR) Comprehensive Biomedical Research Centres (Guy{\textquoteright}s & St. Thomas{\textquoteright} NHS Foundation Trust in partnership with King{\textquoteright}s College London and Cambridge University Hospitals NHS Foundation Trust in partnership with the University of Cambridge); Netherlands Genomics Initiative (NGI)/Netherlands Organisation for Scientific Research (NWO) (050-060-810); Netherlands Organization for the Health Research and Development (ZonMw); Netherlands Organization of Scientific Research NOW (1750102007006, 175.010.2005.011, 911-03-012); Northern Netherlands Collaboration of Provinces (SNN); Norwegian University of Science and Technology; Novo Nordisk; Ontario Institute of Cancer Research and Canadian Cancer Society Research Institute (CCSRI 020214); Republic of Croatia Ministry of Science, Education and Sports research grants (108-1080315-0302); Research Institute for Diseases in the Elderly (RIDE) (014-93-015: RIDE2); Research Into Ageing (251); Siemens Healthcare, Erlangen, Germany and the Federal State of Mecklenburg–West Pomerania; Social Ministry of the Federal State of Mecklenburg–West Pomerania; Structure Enhancing Fund (FES) of the Dutch government; Swedish Heart and Lung Foundation grant 20050561; Swedish Research Council for Worklife and Social research (FAS), grants 2001-0263, 2003-0139; Swiss National Science Foundation (grants no. 4026-28099,3347CO-108796, 3247BO-104283, 3247BO-104288, 3247BO-104284, 32-65896.01,32-59302.99, 32-52720.97, 32-4253.94); The Asthma, Allergy and Inflammation Research Trust; The Great Wine Estates of the Margaret River region of Western Australia; The Netherlands{\textquoteright} Ministry of Economic Affairs, Ministry of Education, Culture and Science and Ministry for Health, Welfare and Sports; The Royal Society; The University of Split and Zagreb Medical Schools; Troms{\o} University; U01 DK062418; UBS Wealth Foundation Grant BA29s8Q7-DZZ; UK Department of Health Policy Research Programme; University Hospital Oulu, Biocenter, University of Oulu, Finland (75617); University Medical Center Groningen; University of Bristol; University of Leicester HEFCE CIF award; University of Nottingham; US National Institutes of Health (NIH) (1P50 CA70907, RO1 CA121197, U19 CA148127, CA55769, CA127219, R01HL071051, R01HL071205, R01HL071250, R01HL071251, R01HL071252, R01HL071258, R01HL071259, UL1RR025005, contracts HHSN268200625226C, HHSN268200782096C, R01-HL084099); US NIH National Cancer Institute (RO1CA111703); US NIH National Center for Research Resources (grants M01-RR00425 and 5M01 RR00997); US NIH National Eye Institute (NEI); US NIH National Heart, Lung and Blood Institute (contracts N01-HC-85079 through N01-HC-85086, N01-HC-35129, N01 HC-15103, N01 HC-55222, N01-HC-75150, N01-HC-45133, N01-HC-95095, N01-HC-48047, N01-HC-48048, N01-HC-48049,",

year = "2011",

month = nov,

doi = "10.1038/ng.941",

language = "English",

volume = "43",

pages = "1082--1090",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Publishing Group",

number = "11",

}

TY - JOUR

T1 - Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function

AU - Artigas, María Soler

AU - Loth, Daan W.

AU - Wain, Louise V.

AU - Gharib, Sina A.

AU - Obeidat, Ma'En

AU - Tang, Wenbo

AU - Zhai, Guangju

AU - Zhao, Jing Hua

AU - Smith, Albert Vernon

AU - Huffman, Jennifer E.

AU - Albrecht, Eva

AU - Jackson, Catherine M.

AU - Evans, David M.

AU - Cadby, Gemma

AU - Fornage, Myriam

AU - Manichaikul, Ani

AU - Lopez, Lorna M.

AU - Johnson, Toby

AU - Aldrich, Melinda C.

AU - Aspelund, Thor

AU - Barroso, Ins

AU - Campbell, Harry

AU - Cassano, Patricia A.

AU - Couper, David J.

AU - Eiriksdottir, Gudny

AU - Franceschini, Nora

AU - Garcia, Melissa

AU - Gieger, Christian

AU - Gislason, Gauti Kjartan

AU - Grkovic, Ivica

AU - Hammond, Christopher J.

AU - Hancock, Dana B.

AU - Harris, Tamara B.

AU - Ramasamy, Adaikalavan

AU - Heckbert, Susan R.

AU - Heliövaara, Markku

AU - Homuth, Georg

AU - Hysi, Pirro G.

AU - James, Alan L.

AU - Jankovic, Stipan

AU - Joubert, Bonnie R.

AU - Karrasch, Stefan

AU - Klopp, Norman

AU - Koch, Beate

AU - Kritchevsky, Stephen B.

AU - Launer, Lenore J.

AU - Liu, Yongmei

AU - Loehr, Laura R.

AU - Lohman, Kurt

AU - Loos, Ruth J.F.

AU - Lumley, Thomas

AU - Al Balushi, Khalid A.

AU - Ang, Wei Q.

AU - Barr, R. Graham

AU - Beilby, John

AU - Blakey, John D.

AU - Boban, Mladen

AU - Boraska, Vesna

AU - Brisman, Jonas

AU - Britton, John R.

AU - Brusselle, Guy G.

AU - Cooper, Cyrus

AU - Curjuric, Ivan

AU - Dahgam, Santosh

AU - Deary, Ian J.

AU - Ebrahim, Shah

AU - Eijgelsheim, Mark

AU - Francks, Clyde

AU - Gaysina, Darya

AU - Granell, Raquel

AU - Gu, Xiangjun

AU - Hankinson, John L.

AU - Hardy, Rebecca

AU - Harris, Sarah E.

AU - Henderson, John

AU - Henry, Amanda

AU - Hingorani, Aroon D.

AU - Hofman, Albert

AU - Holt, Patrick G.

AU - Hui, Jennie

AU - Hunter, Michael L.

AU - Imboden, Medea

AU - Jameson, Karen A.

AU - Kerr, Shona M.

AU - Kolcic, Ivana

AU - Kronenberg, Florian

AU - Liu, Jason Z.

AU - Marchini, Jonathan

AU - McKeever, Tricia

AU - Morris, Andrew D.

AU - Olin, Anna Carin

AU - Porteous, David J.

AU - Postma, Dirkje S.

AU - Rich, Stephen S.

AU - Ring, Susan M.

AU - Rivadeneira, Fernando

AU - Rochat, Thierry

AU - Sayer, Avan Aihie

AU - Sayers, Ian

AU - Sly, Peter D.

AU - Smith, George Davey

AU - Sood, Akshay

AU - Starr, John M.

AU - Uitterlinden, André G.

AU - Vonk, Judith M.

AU - Wannamethee, S. Goya

AU - Whincup, Peter H.

AU - Wijmenga, Cisca

AU - Williams, O. Dale

AU - Wong, Andrew

AU - Mangino, Massimo

AU - Marciante, Kristin D.

AU - McArdle, Wendy L.

AU - Meibohm, Bernd

AU - Morrison, Alanna C.

AU - North, Kari E.

AU - Omenaas, Ernst

AU - Palmer, Lyle J.

AU - Pietiläinen, Kirsi H.

AU - Pin, Isabelle

AU - Polašek, Ozren

AU - Pouta, Anneli

AU - Psaty, Bruce M.

AU - Hartikainen, Anna Liisa

AU - Rantanen, Taina

AU - Ripatti, Samuli

AU - Rotter, Jerome I.

AU - Rudan, Igor

AU - Rudnicka, Alicja R.

AU - Schulz, Holger

AU - Shin, So Youn

AU - Spector, Tim D.

AU - Surakka, Ida

AU - Vitart, Veronique

AU - Völzke, Henry

AU - Wareham, Nicholas J.

AU - Warrington, Nicole M.

AU - Wichmann, H. Erich

AU - Wild, Sarah H.

AU - Wilk, Jemma B.

AU - Wjst, Matthias

AU - Wright, Alan F.

AU - Zgaga, Lina

AU - Zemunik, Tatijana

AU - Pennell, Craig E.

AU - Nyberg, Fredrik

AU - Kuh, Diana

AU - Holloway, John W.

AU - Boezen, H. Marike

AU - Lawlor, Debbie A.

AU - Morris, Richard W.

AU - Probst-Hensch, Nicole

AU - Kaprio, Jaakko

AU - Wilson, James F.

AU - Hayward, Caroline

AU - Kähönen, Mika

AU - Heinrich, Joachim

AU - Musk, Arthur W.

AU - Jarvis, Deborah L.

AU - Gläser, Sven

AU - Järvelin, Marjo Riitta

AU - Ch Stricker, Bruno H.

AU - Elliott, Paul

AU - O'Connor, George T.

AU - Strachan, David P.

AU - London, Stephanie J.

AU - Hall, Ian P.

AU - Gudnason, Vilmundur

AU - Tobin, Martin D.

N1 - Funding Information: We thank the many colleagues who contributed to collection and phenotypic characterization of the clinical sampling, genotyping and analysis of the data. We especially thank those who kindly agreed to participate in the studies. Major funding for this work is from the following sources (alphabetical): Academy of Finland (project grants 104781, 120315, 129269, 1114194, Center of Excellence in Complex Disease Genetics (213506 and 129680) and SALVE); Althingi (Icelandic Parliament); Arthritis Research Campaign; Asthma UK; AstraZeneca; AXA Research Fund; Biotechnology and Biological Sciences Research Council (BBSRC) (BB/F019394/1, G20234); British Heart Foundation (PG/97012, PG/06/154/22043, FS05/125); British Lung Foundation; Canadian Institutes of Health Research (Grant ID MOP-82893); Cancer Research United Kingdom; Funding Information: N01-HC-48050, N01-HC-45134, N01-HC-05187, N01-HC-45205, N01-HC-45204, N01 HC-25195, N01-HC-95159 through N01-HC-95169, RR-024156, N02-HL-6-4278, R01 HL-071022, R01 HL-077612, R01 HL-074104, RC1 HL100543, HHSN268201100005C, HHSN268201100006C, HHSN268201100007C, HHSN268201100008C, HHSN268201100009C, HHSN268201100010C, HHSN268201100011C and HHSN268201100012C, grants HL080295, HL087652, HL105756, R01-HL-084099, R01HL087641, R01HL59367, R01HL086694, HL088133, HL075336 5R01HL087679-02 through the STAMPEED program (1RL1MH083268-01), 1K23HL094531-01); US NIH National Institute of Allergy and Infectious Diseases (NIAID); US NIH National Institute of Child Health and Human Development (NICHD); US NIH National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (DK063491); US NIH National Institute of Environmental Health Sciences (NIEHS) (ZO1 ES49019, ES015794); US NIH National Institute of Mental Health (NIMH) (5R01MH63706:02); US NIH National Institute of Neurological Disorders and Stroke (NINDD); US NIH National Institute on Aging (NIA) (R01 AG032098, RC1 AG035835, N01AG12100, N01AG62101, N01AG62103, N01AG62106, 1R01AG032098-01A1, AG-023269, AG-15928, AG-20098, AG-027058); Wellcome Trust (077016/Z/05/Z, GR069224, 068545/Z/02, 076113/B/04/Z, 079895). Funding Information: Chief Scientist Office, Scottish Government Health Directorate (CZD/16/6); Croatian Institute for Public Health; UK Department of Health; Dutch Kidney Foundation; Erasmus Medical Center and Erasmus University, Rotterdam; Estonian Genome Center, University of Tartu, Estonia (SF0180142s08); EU funding (GABRIEL GRANT Number: 018996, ECRHS II Coordination Number: QLK4-CT-1999-01237); European Commission (DG XII, EURO-BLCS, FP-5 QLG1-CT-2000-01643, FP-6 LSHB-CT-2006-018996 (GABRIEL), FP-6 LSHG-CT-2006-018947 (EUROSPAN), FP-6 GenomEUtwin project QLG2-CT-2002-01254, FP7/2007-2013: HEALTH-F2-2008-201865, GEFOS, HEALTH-F2-2008-35627, TREAT-OA, HEALTH-F4-2007-201413 (ENGAGE)); Finnish Foundation for Cardiovascular Research; Flight Attendant Medical Research Institute (FAMRI); German Asthma and COPD Network (COSYCONET: BMBF grant 01GI0883); German Bundesministerium fuer Forschung und Technology (01 AK 803 A-H, 01 IG 07015 G); German Federal Ministry of Education and Research (BMBF) (03ZIK012, 01ZZ9603, 01ZZ0103 and 01ZZ0403): German National Genome Research Network (NGFN-2 and NGFN-plus); German Ministry of Cultural Affairs; GlaxoSmithKline; Gyllenberg Foundations; Healthway, Western Australia; Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Healthcare and Bioscience iNet (funded by the East Midlands Development Agency, partially financed by the European Regional Development Fund, delivered by Medilink East Midlands); Higher Education Funding Council for England (HEFCE); Hjartavernd (Icelandic Heart Association); Innsbruck Medical University; Institute for Anthropological Research in Zagreb; International Osteoporosis Foundation; Intramural Research Program of the NIH, National Institute on Aging and National Institute of Environmental Health Sciences; Jalmari and Rauha Ahokas Foundation; Juvenile Diabetes Research Foundation International (JDRF); Lifelong Health and Wellbeing Initiative (G0700704/84698); Medical Research Council UK (G1000861, G0501942, G0902313, G0000934, G0800582, G0500539, G0600705, PrevMetSyn/SALVE, G9901462); Medical Research Fund of the Tampere University Hospital; Ministry of Science, Education and Sport of the Republic of Croatia (108-1080315-0302); Medical Research Council Human Genetics Unit; Medisearch–The Leicester Medical Research Foundation; Munich Center of Health Sciences (MC Health) as part of LMUinnovativ; National Health and Medical Research Council of Australia (Grant ID 403981 and ID 003209); National Human Genome Research Institute (NHGRI) (U01-HG-004729, U01-HG-004402); National Institute for Health Research (NIHR) Comprehensive Biomedical Research Centres (Guy’s & St. Thomas’ NHS Foundation Trust in partnership with King’s College London and Cambridge University Hospitals NHS Foundation Trust in partnership with the University of Cambridge); Netherlands Genomics Initiative (NGI)/Netherlands Organisation for Scientific Research (NWO) (050-060-810); Netherlands Organization for the Health Research and Development (ZonMw); Netherlands Organization of Scientific Research NOW (1750102007006, 175.010.2005.011, 911-03-012); Northern Netherlands Collaboration of Provinces (SNN); Norwegian University of Science and Technology; Novo Nordisk; Ontario Institute of Cancer Research and Canadian Cancer Society Research Institute (CCSRI 020214); Republic of Croatia Ministry of Science, Education and Sports research grants (108-1080315-0302); Research Institute for Diseases in the Elderly (RIDE) (014-93-015: RIDE2); Research Into Ageing (251); Siemens Healthcare, Erlangen, Germany and the Federal State of Mecklenburg–West Pomerania; Social Ministry of the Federal State of Mecklenburg–West Pomerania; Structure Enhancing Fund (FES) of the Dutch government; Swedish Heart and Lung Foundation grant 20050561; Swedish Research Council for Worklife and Social research (FAS), grants 2001-0263, 2003-0139; Swiss National Science Foundation (grants no. 4026-28099,3347CO-108796, 3247BO-104283, 3247BO-104288, 3247BO-104284, 32-65896.01,32-59302.99, 32-52720.97, 32-4253.94); The Asthma, Allergy and Inflammation Research Trust; The Great Wine Estates of the Margaret River region of Western Australia; The Netherlands’ Ministry of Economic Affairs, Ministry of Education, Culture and Science and Ministry for Health, Welfare and Sports; The Royal Society; The University of Split and Zagreb Medical Schools; Tromsø University; U01 DK062418; UBS Wealth Foundation Grant BA29s8Q7-DZZ; UK Department of Health Policy Research Programme; University Hospital Oulu, Biocenter, University of Oulu, Finland (75617); University Medical Center Groningen; University of Bristol; University of Leicester HEFCE CIF award; University of Nottingham; US National Institutes of Health (NIH) (1P50 CA70907, RO1 CA121197, U19 CA148127, CA55769, CA127219, R01HL071051, R01HL071205, R01HL071250, R01HL071251, R01HL071252, R01HL071258, R01HL071259, UL1RR025005, contracts HHSN268200625226C, HHSN268200782096C, R01-HL084099); US NIH National Cancer Institute (RO1CA111703); US NIH National Center for Research Resources (grants M01-RR00425 and 5M01 RR00997); US NIH National Eye Institute (NEI); US NIH National Heart, Lung and Blood Institute (contracts N01-HC-85079 through N01-HC-85086, N01-HC-35129, N01 HC-15103, N01 HC-55222, N01-HC-75150, N01-HC-45133, N01-HC-95095, N01-HC-48047, N01-HC-48048, N01-HC-48049,

PY - 2011/11

Y1 - 2011/11

N2 - Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P < 5 ×-10-8) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function.

AB - Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P < 5 ×-10-8) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function.

UR - http://www.scopus.com/inward/record.url?scp=80055008094&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80055008094&partnerID=8YFLogxK

U2 - 10.1038/ng.941

DO - 10.1038/ng.941

M3 - Article

C2 - 21946350

AN - SCOPUS:80055008094

SN - 1061-4036

VL - 43

SP - 1082

EP - 1090

JO - Nature Genetics

JF - Nature Genetics

IS - 11

ER -

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function

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