Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function

María Soler Artigas, Daan W. Loth, Louise V. Wain, Sina A. Gharib, Ma'En Obeidat, Wenbo Tang, Guangju Zhai, Jing Hua Zhao, Albert Vernon Smith, Jennifer E. Huffman, Eva Albrecht, Catherine M. Jackson, David M. Evans, Gemma Cadby, Myriam Fornage, Ani Manichaikul, Lorna M. Lopez, Toby Johnson, Melinda C. Aldrich, Thor AspelundIns Barroso, Harry Campbell, Patricia A. Cassano, David J. Couper, Gudny Eiriksdottir, Nora Franceschini, Melissa Garcia, Christian Gieger, Gauti Kjartan Gislason, Ivica Grkovic, Christopher J. Hammond, Dana B. Hancock, Tamara B. Harris, Adaikalavan Ramasamy, Susan R. Heckbert, Markku Heliövaara, Georg Homuth, Pirro G. Hysi, Alan L. James, Stipan Jankovic, Bonnie R. Joubert, Stefan Karrasch, Norman Klopp, Beate Koch, Stephen B. Kritchevsky, Lenore J. Launer, Yongmei Liu, Laura R. Loehr, Kurt Lohman, Ruth J F Loos, Thomas Lumley, Khalid A. Al Balushi, Wei Q. Ang, R. Graham Barr, John Beilby, John D. Blakey, Mladen Boban, Vesna Boraska, Jonas Brisman, John R. Britton, Guy G. Brusselle, Cyrus Cooper, Ivan Curjuric, Santosh Dahgam, Ian J. Deary, Shah Ebrahim, Mark Eijgelsheim, Clyde Francks, Darya Gaysina, Raquel Granell, Xiangjun Gu, John L. Hankinson, Rebecca Hardy, Sarah E. Harris, John Henderson, Amanda Henry, Aroon D. Hingorani, Albert Hofman, Patrick G. Holt, Jennie Hui, Michael L. Hunter, Medea Imboden, Karen A. Jameson, Shona M. Kerr, Ivana Kolcic, Florian Kronenberg, Jason Z. Liu, Jonathan Marchini, Tricia McKeever, Andrew D. Morris, Anna Carin Olin, David J. Porteous, Dirkje S. Postma, Stephen S. Rich, Susan M. Ring, Fernando Rivadeneira, Thierry Rochat, Avan Aihie Sayer, Ian Sayers, Peter D. Sly, George Davey Smith, Akshay Sood, John M. Starr, André G. Uitterlinden, Judith M. Vonk, S. Goya Wannamethee, Peter H. Whincup, Cisca Wijmenga, O. Dale Williams, Andrew Wong, Massimo Mangino, Kristin D. Marciante, Wendy L. McArdle, Bernd Meibohm, Alanna C. Morrison, Kari E. North, Ernst Omenaas, Lyle J. Palmer, Kirsi H. Pietiläinen, Isabelle Pin, Ozren Polašek, Anneli Pouta, Bruce M. Psaty, Anna Liisa Hartikainen, Taina Rantanen, Samuli Ripatti, Jerome I. Rotter, Igor Rudan, Alicja R. Rudnicka, Holger Schulz, So Youn Shin, Tim D. Spector, Ida Surakka, Veronique Vitart, Henry Völzke, Nicholas J. Wareham, Nicole M. Warrington, H. Erich Wichmann, Sarah H. Wild, Jemma B. Wilk, Matthias Wjst, Alan F. Wright, Lina Zgaga, Tatijana Zemunik, Craig E. Pennell, Fredrik Nyberg, Diana Kuh, John W. Holloway, H. Marike Boezen, Debbie A. Lawlor, Richard W. Morris, Nicole Probst-Hensch, Jaakko Kaprio, James F. Wilson, Caroline Hayward, Mika Kähönen, Joachim Heinrich, Arthur W. Musk, Deborah L. Jarvis, Sven Gläser, Marjo Riitta Järvelin, Bruno H. Ch Stricker, Paul Elliott, George T. O'Connor, David P. Strachan, Stephanie J. London, Ian P. Hall, Vilmundur Gudnason, Martin D. Tobin

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266 Citations (Scopus)

Abstract

Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P <5 ×-10-8) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function.

Original languageEnglish
Pages (from-to)1082-1090
Number of pages9
JournalNature Genetics
Volume43
Issue number11
DOIs
Publication statusPublished - Nov 2011

ASJC Scopus subject areas

  • Genetics

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    Artigas, M. S., Loth, D. W., Wain, L. V., Gharib, S. A., Obeidat, ME., Tang, W., Zhai, G., Zhao, J. H., Smith, A. V., Huffman, J. E., Albrecht, E., Jackson, C. M., Evans, D. M., Cadby, G., Fornage, M., Manichaikul, A., Lopez, L. M., Johnson, T., Aldrich, M. C., ... Tobin, M. D. (2011). Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nature Genetics, 43(11), 1082-1090. https://doi.org/10.1038/ng.941