Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function

María Soler Artigas, Daan W. Loth, Louise V. Wain, Sina A. Gharib, Ma'En Obeidat, Wenbo Tang, Guangju Zhai, Jing Hua Zhao, Albert Vernon Smith, Jennifer E. Huffman, Eva Albrecht, Catherine M. Jackson, David M. Evans, Gemma Cadby, Myriam Fornage, Ani Manichaikul, Lorna M. Lopez, Toby Johnson, Melinda C. Aldrich, Thor Aspelund & 149 others Ins Barroso, Harry Campbell, Patricia A. Cassano, David J. Couper, Gudny Eiriksdottir, Nora Franceschini, Melissa Garcia, Christian Gieger, Gauti Kjartan Gislason, Ivica Grkovic, Christopher J. Hammond, Dana B. Hancock, Tamara B. Harris, Adaikalavan Ramasamy, Susan R. Heckbert, Markku Heliövaara, Georg Homuth, Pirro G. Hysi, Alan L. James, Stipan Jankovic, Bonnie R. Joubert, Stefan Karrasch, Norman Klopp, Beate Koch, Stephen B. Kritchevsky, Lenore J. Launer, Yongmei Liu, Laura R. Loehr, Kurt Lohman, Ruth J F Loos, Thomas Lumley, Khalid A. Al Balushi, Wei Q. Ang, R. Graham Barr, John Beilby, John D. Blakey, Mladen Boban, Vesna Boraska, Jonas Brisman, John R. Britton, Guy G. Brusselle, Cyrus Cooper, Ivan Curjuric, Santosh Dahgam, Ian J. Deary, Shah Ebrahim, Mark Eijgelsheim, Clyde Francks, Darya Gaysina, Raquel Granell, Xiangjun Gu, John L. Hankinson, Rebecca Hardy, Sarah E. Harris, John Henderson, Amanda Henry, Aroon D. Hingorani, Albert Hofman, Patrick G. Holt, Jennie Hui, Michael L. Hunter, Medea Imboden, Karen A. Jameson, Shona M. Kerr, Ivana Kolcic, Florian Kronenberg, Jason Z. Liu, Jonathan Marchini, Tricia McKeever, Andrew D. Morris, Anna Carin Olin, David J. Porteous, Dirkje S. Postma, Stephen S. Rich, Susan M. Ring, Fernando Rivadeneira, Thierry Rochat, Avan Aihie Sayer, Ian Sayers, Peter D. Sly, George Davey Smith, Akshay Sood, John M. Starr, André G. Uitterlinden, Judith M. Vonk, S. Goya Wannamethee, Peter H. Whincup, Cisca Wijmenga, O. Dale Williams, Andrew Wong, Massimo Mangino, Kristin D. Marciante, Wendy L. McArdle, Bernd Meibohm, Alanna C. Morrison, Kari E. North, Ernst Omenaas, Lyle J. Palmer, Kirsi H. Pietiläinen, Isabelle Pin, Ozren Polašek, Anneli Pouta, Bruce M. Psaty, Anna Liisa Hartikainen, Taina Rantanen, Samuli Ripatti, Jerome I. Rotter, Igor Rudan, Alicja R. Rudnicka, Holger Schulz, So Youn Shin, Tim D. Spector, Ida Surakka, Veronique Vitart, Henry Völzke, Nicholas J. Wareham, Nicole M. Warrington, H. Erich Wichmann, Sarah H. Wild, Jemma B. Wilk, Matthias Wjst, Alan F. Wright, Lina Zgaga, Tatijana Zemunik, Craig E. Pennell, Fredrik Nyberg, Diana Kuh, John W. Holloway, H. Marike Boezen, Debbie A. Lawlor, Richard W. Morris, Nicole Probst-Hensch, Jaakko Kaprio, James F. Wilson, Caroline Hayward, Mika Kähönen, Joachim Heinrich, Arthur W. Musk, Deborah L. Jarvis, Sven Gläser, Marjo Riitta Järvelin, Bruno H. Ch Stricker, Paul Elliott, George T. O'Connor, David P. Strachan, Stephanie J. London, Ian P. Hall, Vilmundur Gudnason, Martin D. Tobin

Research output: Contribution to journalArticle

251 Citations (Scopus)

Abstract

Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P <5 ×-10-8) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function.

Original languageEnglish
Pages (from-to)1082-1090
Number of pages9
JournalNature Genetics
Volume43
Issue number11
DOIs
Publication statusPublished - Nov 2011

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Genome
Lung
Forced Expiratory Volume
Vital Capacity
Chronic Obstructive Pulmonary Disease
Health
Therapeutics

ASJC Scopus subject areas

  • Genetics

Cite this

Artigas, M. S., Loth, D. W., Wain, L. V., Gharib, S. A., Obeidat, ME., Tang, W., ... Tobin, M. D. (2011). Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nature Genetics, 43(11), 1082-1090. https://doi.org/10.1038/ng.941

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. / Artigas, María Soler; Loth, Daan W.; Wain, Louise V.; Gharib, Sina A.; Obeidat, Ma'En; Tang, Wenbo; Zhai, Guangju; Zhao, Jing Hua; Smith, Albert Vernon; Huffman, Jennifer E.; Albrecht, Eva; Jackson, Catherine M.; Evans, David M.; Cadby, Gemma; Fornage, Myriam; Manichaikul, Ani; Lopez, Lorna M.; Johnson, Toby; Aldrich, Melinda C.; Aspelund, Thor; Barroso, Ins; Campbell, Harry; Cassano, Patricia A.; Couper, David J.; Eiriksdottir, Gudny; Franceschini, Nora; Garcia, Melissa; Gieger, Christian; Gislason, Gauti Kjartan; Grkovic, Ivica; Hammond, Christopher J.; Hancock, Dana B.; Harris, Tamara B.; Ramasamy, Adaikalavan; Heckbert, Susan R.; Heliövaara, Markku; Homuth, Georg; Hysi, Pirro G.; James, Alan L.; Jankovic, Stipan; Joubert, Bonnie R.; Karrasch, Stefan; Klopp, Norman; Koch, Beate; Kritchevsky, Stephen B.; Launer, Lenore J.; Liu, Yongmei; Loehr, Laura R.; Lohman, Kurt; Loos, Ruth J F; Lumley, Thomas; Al Balushi, Khalid A.; Ang, Wei Q.; Barr, R. Graham; Beilby, John; Blakey, John D.; Boban, Mladen; Boraska, Vesna; Brisman, Jonas; Britton, John R.; Brusselle, Guy G.; Cooper, Cyrus; Curjuric, Ivan; Dahgam, Santosh; Deary, Ian J.; Ebrahim, Shah; Eijgelsheim, Mark; Francks, Clyde; Gaysina, Darya; Granell, Raquel; Gu, Xiangjun; Hankinson, John L.; Hardy, Rebecca; Harris, Sarah E.; Henderson, John; Henry, Amanda; Hingorani, Aroon D.; Hofman, Albert; Holt, Patrick G.; Hui, Jennie; Hunter, Michael L.; Imboden, Medea; Jameson, Karen A.; Kerr, Shona M.; Kolcic, Ivana; Kronenberg, Florian; Liu, Jason Z.; Marchini, Jonathan; McKeever, Tricia; Morris, Andrew D.; Olin, Anna Carin; Porteous, David J.; Postma, Dirkje S.; Rich, Stephen S.; Ring, Susan M.; Rivadeneira, Fernando; Rochat, Thierry; Sayer, Avan Aihie; Sayers, Ian; Sly, Peter D.; Smith, George Davey; Sood, Akshay; Starr, John M.; Uitterlinden, André G.; Vonk, Judith M.; Wannamethee, S. Goya; Whincup, Peter H.; Wijmenga, Cisca; Williams, O. Dale; Wong, Andrew; Mangino, Massimo; Marciante, Kristin D.; McArdle, Wendy L.; Meibohm, Bernd; Morrison, Alanna C.; North, Kari E.; Omenaas, Ernst; Palmer, Lyle J.; Pietiläinen, Kirsi H.; Pin, Isabelle; Polašek, Ozren; Pouta, Anneli; Psaty, Bruce M.; Hartikainen, Anna Liisa; Rantanen, Taina; Ripatti, Samuli; Rotter, Jerome I.; Rudan, Igor; Rudnicka, Alicja R.; Schulz, Holger; Shin, So Youn; Spector, Tim D.; Surakka, Ida; Vitart, Veronique; Völzke, Henry; Wareham, Nicholas J.; Warrington, Nicole M.; Wichmann, H. Erich; Wild, Sarah H.; Wilk, Jemma B.; Wjst, Matthias; Wright, Alan F.; Zgaga, Lina; Zemunik, Tatijana; Pennell, Craig E.; Nyberg, Fredrik; Kuh, Diana; Holloway, John W.; Boezen, H. Marike; Lawlor, Debbie A.; Morris, Richard W.; Probst-Hensch, Nicole; Kaprio, Jaakko; Wilson, James F.; Hayward, Caroline; Kähönen, Mika; Heinrich, Joachim; Musk, Arthur W.; Jarvis, Deborah L.; Gläser, Sven; Järvelin, Marjo Riitta; Ch Stricker, Bruno H.; Elliott, Paul; O'Connor, George T.; Strachan, David P.; London, Stephanie J.; Hall, Ian P.; Gudnason, Vilmundur; Tobin, Martin D.

In: Nature Genetics, Vol. 43, No. 11, 11.2011, p. 1082-1090.

Research output: Contribution to journalArticle

Artigas, MS, Loth, DW, Wain, LV, Gharib, SA, Obeidat, ME, Tang, W, Zhai, G, Zhao, JH, Smith, AV, Huffman, JE, Albrecht, E, Jackson, CM, Evans, DM, Cadby, G, Fornage, M, Manichaikul, A, Lopez, LM, Johnson, T, Aldrich, MC, Aspelund, T, Barroso, I, Campbell, H, Cassano, PA, Couper, DJ, Eiriksdottir, G, Franceschini, N, Garcia, M, Gieger, C, Gislason, GK, Grkovic, I, Hammond, CJ, Hancock, DB, Harris, TB, Ramasamy, A, Heckbert, SR, Heliövaara, M, Homuth, G, Hysi, PG, James, AL, Jankovic, S, Joubert, BR, Karrasch, S, Klopp, N, Koch, B, Kritchevsky, SB, Launer, LJ, Liu, Y, Loehr, LR, Lohman, K, Loos, RJF, Lumley, T, Al Balushi, KA, Ang, WQ, Barr, RG, Beilby, J, Blakey, JD, Boban, M, Boraska, V, Brisman, J, Britton, JR, Brusselle, GG, Cooper, C, Curjuric, I, Dahgam, S, Deary, IJ, Ebrahim, S, Eijgelsheim, M, Francks, C, Gaysina, D, Granell, R, Gu, X, Hankinson, JL, Hardy, R, Harris, SE, Henderson, J, Henry, A, Hingorani, AD, Hofman, A, Holt, PG, Hui, J, Hunter, ML, Imboden, M, Jameson, KA, Kerr, SM, Kolcic, I, Kronenberg, F, Liu, JZ, Marchini, J, McKeever, T, Morris, AD, Olin, AC, Porteous, DJ, Postma, DS, Rich, SS, Ring, SM, Rivadeneira, F, Rochat, T, Sayer, AA, Sayers, I, Sly, PD, Smith, GD, Sood, A, Starr, JM, Uitterlinden, AG, Vonk, JM, Wannamethee, SG, Whincup, PH, Wijmenga, C, Williams, OD, Wong, A, Mangino, M, Marciante, KD, McArdle, WL, Meibohm, B, Morrison, AC, North, KE, Omenaas, E, Palmer, LJ, Pietiläinen, KH, Pin, I, Polašek, O, Pouta, A, Psaty, BM, Hartikainen, AL, Rantanen, T, Ripatti, S, Rotter, JI, Rudan, I, Rudnicka, AR, Schulz, H, Shin, SY, Spector, TD, Surakka, I, Vitart, V, Völzke, H, Wareham, NJ, Warrington, NM, Wichmann, HE, Wild, SH, Wilk, JB, Wjst, M, Wright, AF, Zgaga, L, Zemunik, T, Pennell, CE, Nyberg, F, Kuh, D, Holloway, JW, Boezen, HM, Lawlor, DA, Morris, RW, Probst-Hensch, N, Kaprio, J, Wilson, JF, Hayward, C, Kähönen, M, Heinrich, J, Musk, AW, Jarvis, DL, Gläser, S, Järvelin, MR, Ch Stricker, BH, Elliott, P, O'Connor, GT, Strachan, DP, London, SJ, Hall, IP, Gudnason, V & Tobin, MD 2011, 'Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function', Nature Genetics, vol. 43, no. 11, pp. 1082-1090. https://doi.org/10.1038/ng.941
Artigas MS, Loth DW, Wain LV, Gharib SA, Obeidat ME, Tang W et al. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nature Genetics. 2011 Nov;43(11):1082-1090. https://doi.org/10.1038/ng.941
Artigas, María Soler ; Loth, Daan W. ; Wain, Louise V. ; Gharib, Sina A. ; Obeidat, Ma'En ; Tang, Wenbo ; Zhai, Guangju ; Zhao, Jing Hua ; Smith, Albert Vernon ; Huffman, Jennifer E. ; Albrecht, Eva ; Jackson, Catherine M. ; Evans, David M. ; Cadby, Gemma ; Fornage, Myriam ; Manichaikul, Ani ; Lopez, Lorna M. ; Johnson, Toby ; Aldrich, Melinda C. ; Aspelund, Thor ; Barroso, Ins ; Campbell, Harry ; Cassano, Patricia A. ; Couper, David J. ; Eiriksdottir, Gudny ; Franceschini, Nora ; Garcia, Melissa ; Gieger, Christian ; Gislason, Gauti Kjartan ; Grkovic, Ivica ; Hammond, Christopher J. ; Hancock, Dana B. ; Harris, Tamara B. ; Ramasamy, Adaikalavan ; Heckbert, Susan R. ; Heliövaara, Markku ; Homuth, Georg ; Hysi, Pirro G. ; James, Alan L. ; Jankovic, Stipan ; Joubert, Bonnie R. ; Karrasch, Stefan ; Klopp, Norman ; Koch, Beate ; Kritchevsky, Stephen B. ; Launer, Lenore J. ; Liu, Yongmei ; Loehr, Laura R. ; Lohman, Kurt ; Loos, Ruth J F ; Lumley, Thomas ; Al Balushi, Khalid A. ; Ang, Wei Q. ; Barr, R. Graham ; Beilby, John ; Blakey, John D. ; Boban, Mladen ; Boraska, Vesna ; Brisman, Jonas ; Britton, John R. ; Brusselle, Guy G. ; Cooper, Cyrus ; Curjuric, Ivan ; Dahgam, Santosh ; Deary, Ian J. ; Ebrahim, Shah ; Eijgelsheim, Mark ; Francks, Clyde ; Gaysina, Darya ; Granell, Raquel ; Gu, Xiangjun ; Hankinson, John L. ; Hardy, Rebecca ; Harris, Sarah E. ; Henderson, John ; Henry, Amanda ; Hingorani, Aroon D. ; Hofman, Albert ; Holt, Patrick G. ; Hui, Jennie ; Hunter, Michael L. ; Imboden, Medea ; Jameson, Karen A. ; Kerr, Shona M. ; Kolcic, Ivana ; Kronenberg, Florian ; Liu, Jason Z. ; Marchini, Jonathan ; McKeever, Tricia ; Morris, Andrew D. ; Olin, Anna Carin ; Porteous, David J. ; Postma, Dirkje S. ; Rich, Stephen S. ; Ring, Susan M. ; Rivadeneira, Fernando ; Rochat, Thierry ; Sayer, Avan Aihie ; Sayers, Ian ; Sly, Peter D. ; Smith, George Davey ; Sood, Akshay ; Starr, John M. ; Uitterlinden, André G. ; Vonk, Judith M. ; Wannamethee, S. Goya ; Whincup, Peter H. ; Wijmenga, Cisca ; Williams, O. Dale ; Wong, Andrew ; Mangino, Massimo ; Marciante, Kristin D. ; McArdle, Wendy L. ; Meibohm, Bernd ; Morrison, Alanna C. ; North, Kari E. ; Omenaas, Ernst ; Palmer, Lyle J. ; Pietiläinen, Kirsi H. ; Pin, Isabelle ; Polašek, Ozren ; Pouta, Anneli ; Psaty, Bruce M. ; Hartikainen, Anna Liisa ; Rantanen, Taina ; Ripatti, Samuli ; Rotter, Jerome I. ; Rudan, Igor ; Rudnicka, Alicja R. ; Schulz, Holger ; Shin, So Youn ; Spector, Tim D. ; Surakka, Ida ; Vitart, Veronique ; Völzke, Henry ; Wareham, Nicholas J. ; Warrington, Nicole M. ; Wichmann, H. Erich ; Wild, Sarah H. ; Wilk, Jemma B. ; Wjst, Matthias ; Wright, Alan F. ; Zgaga, Lina ; Zemunik, Tatijana ; Pennell, Craig E. ; Nyberg, Fredrik ; Kuh, Diana ; Holloway, John W. ; Boezen, H. Marike ; Lawlor, Debbie A. ; Morris, Richard W. ; Probst-Hensch, Nicole ; Kaprio, Jaakko ; Wilson, James F. ; Hayward, Caroline ; Kähönen, Mika ; Heinrich, Joachim ; Musk, Arthur W. ; Jarvis, Deborah L. ; Gläser, Sven ; Järvelin, Marjo Riitta ; Ch Stricker, Bruno H. ; Elliott, Paul ; O'Connor, George T. ; Strachan, David P. ; London, Stephanie J. ; Hall, Ian P. ; Gudnason, Vilmundur ; Tobin, Martin D. / Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. In: Nature Genetics. 2011 ; Vol. 43, No. 11. pp. 1082-1090.
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title = "Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function",
abstract = "Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P <5 ×-10-8) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function.",
author = "Artigas, {Mar{\'i}a Soler} and Loth, {Daan W.} and Wain, {Louise V.} and Gharib, {Sina A.} and Ma'En Obeidat and Wenbo Tang and Guangju Zhai and Zhao, {Jing Hua} and Smith, {Albert Vernon} and Huffman, {Jennifer E.} and Eva Albrecht and Jackson, {Catherine M.} and Evans, {David M.} and Gemma Cadby and Myriam Fornage and Ani Manichaikul and Lopez, {Lorna M.} and Toby Johnson and Aldrich, {Melinda C.} and Thor Aspelund and Ins Barroso and Harry Campbell and Cassano, {Patricia A.} and Couper, {David J.} and Gudny Eiriksdottir and Nora Franceschini and Melissa Garcia and Christian Gieger and Gislason, {Gauti Kjartan} and Ivica Grkovic and Hammond, {Christopher J.} and Hancock, {Dana B.} and Harris, {Tamara B.} and Adaikalavan Ramasamy and Heckbert, {Susan R.} and Markku Heli{\"o}vaara and Georg Homuth and Hysi, {Pirro G.} and James, {Alan L.} and Stipan Jankovic and Joubert, {Bonnie R.} and Stefan Karrasch and Norman Klopp and Beate Koch and Kritchevsky, {Stephen B.} and Launer, {Lenore J.} and Yongmei Liu and Loehr, {Laura R.} and Kurt Lohman and Loos, {Ruth J F} and Thomas Lumley and {Al Balushi}, {Khalid A.} and Ang, {Wei Q.} and Barr, {R. Graham} and John Beilby and Blakey, {John D.} and Mladen Boban and Vesna Boraska and Jonas Brisman and Britton, {John R.} and Brusselle, {Guy G.} and Cyrus Cooper and Ivan Curjuric and Santosh Dahgam and Deary, {Ian J.} and Shah Ebrahim and Mark Eijgelsheim and Clyde Francks and Darya Gaysina and Raquel Granell and Xiangjun Gu and Hankinson, {John L.} and Rebecca Hardy and Harris, {Sarah E.} and John Henderson and Amanda Henry and Hingorani, {Aroon D.} and Albert Hofman and Holt, {Patrick G.} and Jennie Hui and Hunter, {Michael L.} and Medea Imboden and Jameson, {Karen A.} and Kerr, {Shona M.} and Ivana Kolcic and Florian Kronenberg and Liu, {Jason Z.} and Jonathan Marchini and Tricia McKeever and Morris, {Andrew D.} and Olin, {Anna Carin} and Porteous, {David J.} and Postma, {Dirkje S.} and Rich, {Stephen S.} and Ring, {Susan M.} and Fernando Rivadeneira and Thierry Rochat and Sayer, {Avan Aihie} and Ian Sayers and Sly, {Peter D.} and Smith, {George Davey} and Akshay Sood and Starr, {John M.} and Uitterlinden, {Andr{\'e} G.} and Vonk, {Judith M.} and Wannamethee, {S. Goya} and Whincup, {Peter H.} and Cisca Wijmenga and Williams, {O. Dale} and Andrew Wong and Massimo Mangino and Marciante, {Kristin D.} and McArdle, {Wendy L.} and Bernd Meibohm and Morrison, {Alanna C.} and North, {Kari E.} and Ernst Omenaas and Palmer, {Lyle J.} and Pietil{\"a}inen, {Kirsi H.} and Isabelle Pin and Ozren Polašek and Anneli Pouta and Psaty, {Bruce M.} and Hartikainen, {Anna Liisa} and Taina Rantanen and Samuli Ripatti and Rotter, {Jerome I.} and Igor Rudan and Rudnicka, {Alicja R.} and Holger Schulz and Shin, {So Youn} and Spector, {Tim D.} and Ida Surakka and Veronique Vitart and Henry V{\"o}lzke and Wareham, {Nicholas J.} and Warrington, {Nicole M.} and Wichmann, {H. Erich} and Wild, {Sarah H.} and Wilk, {Jemma B.} and Matthias Wjst and Wright, {Alan F.} and Lina Zgaga and Tatijana Zemunik and Pennell, {Craig E.} and Fredrik Nyberg and Diana Kuh and Holloway, {John W.} and Boezen, {H. Marike} and Lawlor, {Debbie A.} and Morris, {Richard W.} and Nicole Probst-Hensch and Jaakko Kaprio and Wilson, {James F.} and Caroline Hayward and Mika K{\"a}h{\"o}nen and Joachim Heinrich and Musk, {Arthur W.} and Jarvis, {Deborah L.} and Sven Gl{\"a}ser and J{\"a}rvelin, {Marjo Riitta} and {Ch Stricker}, {Bruno H.} and Paul Elliott and O'Connor, {George T.} and Strachan, {David P.} and London, {Stephanie J.} and Hall, {Ian P.} and Vilmundur Gudnason and Tobin, {Martin D.}",
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TY - JOUR

T1 - Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function

AU - Artigas, María Soler

AU - Loth, Daan W.

AU - Wain, Louise V.

AU - Gharib, Sina A.

AU - Obeidat, Ma'En

AU - Tang, Wenbo

AU - Zhai, Guangju

AU - Zhao, Jing Hua

AU - Smith, Albert Vernon

AU - Huffman, Jennifer E.

AU - Albrecht, Eva

AU - Jackson, Catherine M.

AU - Evans, David M.

AU - Cadby, Gemma

AU - Fornage, Myriam

AU - Manichaikul, Ani

AU - Lopez, Lorna M.

AU - Johnson, Toby

AU - Aldrich, Melinda C.

AU - Aspelund, Thor

AU - Barroso, Ins

AU - Campbell, Harry

AU - Cassano, Patricia A.

AU - Couper, David J.

AU - Eiriksdottir, Gudny

AU - Franceschini, Nora

AU - Garcia, Melissa

AU - Gieger, Christian

AU - Gislason, Gauti Kjartan

AU - Grkovic, Ivica

AU - Hammond, Christopher J.

AU - Hancock, Dana B.

AU - Harris, Tamara B.

AU - Ramasamy, Adaikalavan

AU - Heckbert, Susan R.

AU - Heliövaara, Markku

AU - Homuth, Georg

AU - Hysi, Pirro G.

AU - James, Alan L.

AU - Jankovic, Stipan

AU - Joubert, Bonnie R.

AU - Karrasch, Stefan

AU - Klopp, Norman

AU - Koch, Beate

AU - Kritchevsky, Stephen B.

AU - Launer, Lenore J.

AU - Liu, Yongmei

AU - Loehr, Laura R.

AU - Lohman, Kurt

AU - Loos, Ruth J F

AU - Lumley, Thomas

AU - Al Balushi, Khalid A.

AU - Ang, Wei Q.

AU - Barr, R. Graham

AU - Beilby, John

AU - Blakey, John D.

AU - Boban, Mladen

AU - Boraska, Vesna

AU - Brisman, Jonas

AU - Britton, John R.

AU - Brusselle, Guy G.

AU - Cooper, Cyrus

AU - Curjuric, Ivan

AU - Dahgam, Santosh

AU - Deary, Ian J.

AU - Ebrahim, Shah

AU - Eijgelsheim, Mark

AU - Francks, Clyde

AU - Gaysina, Darya

AU - Granell, Raquel

AU - Gu, Xiangjun

AU - Hankinson, John L.

AU - Hardy, Rebecca

AU - Harris, Sarah E.

AU - Henderson, John

AU - Henry, Amanda

AU - Hingorani, Aroon D.

AU - Hofman, Albert

AU - Holt, Patrick G.

AU - Hui, Jennie

AU - Hunter, Michael L.

AU - Imboden, Medea

AU - Jameson, Karen A.

AU - Kerr, Shona M.

AU - Kolcic, Ivana

AU - Kronenberg, Florian

AU - Liu, Jason Z.

AU - Marchini, Jonathan

AU - McKeever, Tricia

AU - Morris, Andrew D.

AU - Olin, Anna Carin

AU - Porteous, David J.

AU - Postma, Dirkje S.

AU - Rich, Stephen S.

AU - Ring, Susan M.

AU - Rivadeneira, Fernando

AU - Rochat, Thierry

AU - Sayer, Avan Aihie

AU - Sayers, Ian

AU - Sly, Peter D.

AU - Smith, George Davey

AU - Sood, Akshay

AU - Starr, John M.

AU - Uitterlinden, André G.

AU - Vonk, Judith M.

AU - Wannamethee, S. Goya

AU - Whincup, Peter H.

AU - Wijmenga, Cisca

AU - Williams, O. Dale

AU - Wong, Andrew

AU - Mangino, Massimo

AU - Marciante, Kristin D.

AU - McArdle, Wendy L.

AU - Meibohm, Bernd

AU - Morrison, Alanna C.

AU - North, Kari E.

AU - Omenaas, Ernst

AU - Palmer, Lyle J.

AU - Pietiläinen, Kirsi H.

AU - Pin, Isabelle

AU - Polašek, Ozren

AU - Pouta, Anneli

AU - Psaty, Bruce M.

AU - Hartikainen, Anna Liisa

AU - Rantanen, Taina

AU - Ripatti, Samuli

AU - Rotter, Jerome I.

AU - Rudan, Igor

AU - Rudnicka, Alicja R.

AU - Schulz, Holger

AU - Shin, So Youn

AU - Spector, Tim D.

AU - Surakka, Ida

AU - Vitart, Veronique

AU - Völzke, Henry

AU - Wareham, Nicholas J.

AU - Warrington, Nicole M.

AU - Wichmann, H. Erich

AU - Wild, Sarah H.

AU - Wilk, Jemma B.

AU - Wjst, Matthias

AU - Wright, Alan F.

AU - Zgaga, Lina

AU - Zemunik, Tatijana

AU - Pennell, Craig E.

AU - Nyberg, Fredrik

AU - Kuh, Diana

AU - Holloway, John W.

AU - Boezen, H. Marike

AU - Lawlor, Debbie A.

AU - Morris, Richard W.

AU - Probst-Hensch, Nicole

AU - Kaprio, Jaakko

AU - Wilson, James F.

AU - Hayward, Caroline

AU - Kähönen, Mika

AU - Heinrich, Joachim

AU - Musk, Arthur W.

AU - Jarvis, Deborah L.

AU - Gläser, Sven

AU - Järvelin, Marjo Riitta

AU - Ch Stricker, Bruno H.

AU - Elliott, Paul

AU - O'Connor, George T.

AU - Strachan, David P.

AU - London, Stephanie J.

AU - Hall, Ian P.

AU - Gudnason, Vilmundur

AU - Tobin, Martin D.

PY - 2011/11

Y1 - 2011/11

N2 - Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P <5 ×-10-8) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function.

AB - Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P <5 ×-10-8) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function.

UR - http://www.scopus.com/inward/record.url?scp=80055008094&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80055008094&partnerID=8YFLogxK

U2 - 10.1038/ng.941

DO - 10.1038/ng.941

M3 - Article

VL - 43

SP - 1082

EP - 1090

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 11

ER -