Abstract
Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P <5 ×-10-8) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function.
| Original language | English |
|---|---|
| Pages (from-to) | 1082-1090 |
| Number of pages | 9 |
| Journal | Nature Genetics |
| Volume | 43 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Nov 2011 |
ASJC Scopus subject areas
- Genetics
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Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. / Artigas, María Soler; Loth, Daan W.; Wain, Louise V.; Gharib, Sina A.; Obeidat, Ma'En; Tang, Wenbo; Zhai, Guangju; Zhao, Jing Hua; Smith, Albert Vernon; Huffman, Jennifer E.; Albrecht, Eva; Jackson, Catherine M.; Evans, David M.; Cadby, Gemma; Fornage, Myriam; Manichaikul, Ani; Lopez, Lorna M.; Johnson, Toby; Aldrich, Melinda C.; Aspelund, Thor; Barroso, Ins; Campbell, Harry; Cassano, Patricia A.; Couper, David J.; Eiriksdottir, Gudny; Franceschini, Nora; Garcia, Melissa; Gieger, Christian; Gislason, Gauti Kjartan; Grkovic, Ivica; Hammond, Christopher J.; Hancock, Dana B.; Harris, Tamara B.; Ramasamy, Adaikalavan; Heckbert, Susan R.; Heliövaara, Markku; Homuth, Georg; Hysi, Pirro G.; James, Alan L.; Jankovic, Stipan; Joubert, Bonnie R.; Karrasch, Stefan; Klopp, Norman; Koch, Beate; Kritchevsky, Stephen B.; Launer, Lenore J.; Liu, Yongmei; Loehr, Laura R.; Lohman, Kurt; Loos, Ruth J F; Lumley, Thomas; Al Balushi, Khalid A.; Ang, Wei Q.; Barr, R. Graham; Beilby, John; Blakey, John D.; Boban, Mladen; Boraska, Vesna; Brisman, Jonas; Britton, John R.; Brusselle, Guy G.; Cooper, Cyrus; Curjuric, Ivan; Dahgam, Santosh; Deary, Ian J.; Ebrahim, Shah; Eijgelsheim, Mark; Francks, Clyde; Gaysina, Darya; Granell, Raquel; Gu, Xiangjun; Hankinson, John L.; Hardy, Rebecca; Harris, Sarah E.; Henderson, John; Henry, Amanda; Hingorani, Aroon D.; Hofman, Albert; Holt, Patrick G.; Hui, Jennie; Hunter, Michael L.; Imboden, Medea; Jameson, Karen A.; Kerr, Shona M.; Kolcic, Ivana; Kronenberg, Florian; Liu, Jason Z.; Marchini, Jonathan; McKeever, Tricia; Morris, Andrew D.; Olin, Anna Carin; Porteous, David J.; Postma, Dirkje S.; Rich, Stephen S.; Ring, Susan M.; Rivadeneira, Fernando; Rochat, Thierry; Sayer, Avan Aihie; Sayers, Ian; Sly, Peter D.; Smith, George Davey; Sood, Akshay; Starr, John M.; Uitterlinden, André G.; Vonk, Judith M.; Wannamethee, S. Goya; Whincup, Peter H.; Wijmenga, Cisca; Williams, O. Dale; Wong, Andrew; Mangino, Massimo; Marciante, Kristin D.; McArdle, Wendy L.; Meibohm, Bernd; Morrison, Alanna C.; North, Kari E.; Omenaas, Ernst; Palmer, Lyle J.; Pietiläinen, Kirsi H.; Pin, Isabelle; Polašek, Ozren; Pouta, Anneli; Psaty, Bruce M.; Hartikainen, Anna Liisa; Rantanen, Taina; Ripatti, Samuli; Rotter, Jerome I.; Rudan, Igor; Rudnicka, Alicja R.; Schulz, Holger; Shin, So Youn; Spector, Tim D.; Surakka, Ida; Vitart, Veronique; Völzke, Henry; Wareham, Nicholas J.; Warrington, Nicole M.; Wichmann, H. Erich; Wild, Sarah H.; Wilk, Jemma B.; Wjst, Matthias; Wright, Alan F.; Zgaga, Lina; Zemunik, Tatijana; Pennell, Craig E.; Nyberg, Fredrik; Kuh, Diana; Holloway, John W.; Boezen, H. Marike; Lawlor, Debbie A.; Morris, Richard W.; Probst-Hensch, Nicole; Kaprio, Jaakko; Wilson, James F.; Hayward, Caroline; Kähönen, Mika; Heinrich, Joachim; Musk, Arthur W.; Jarvis, Deborah L.; Gläser, Sven; Järvelin, Marjo Riitta; Ch Stricker, Bruno H.; Elliott, Paul; O'Connor, George T.; Strachan, David P.; London, Stephanie J.; Hall, Ian P.; Gudnason, Vilmundur; Tobin, Martin D.
In: Nature Genetics, Vol. 43, No. 11, 11.2011, p. 1082-1090.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function
AU - Artigas, María Soler
AU - Loth, Daan W.
AU - Wain, Louise V.
AU - Gharib, Sina A.
AU - Obeidat, Ma'En
AU - Tang, Wenbo
AU - Zhai, Guangju
AU - Zhao, Jing Hua
AU - Smith, Albert Vernon
AU - Huffman, Jennifer E.
AU - Albrecht, Eva
AU - Jackson, Catherine M.
AU - Evans, David M.
AU - Cadby, Gemma
AU - Fornage, Myriam
AU - Manichaikul, Ani
AU - Lopez, Lorna M.
AU - Johnson, Toby
AU - Aldrich, Melinda C.
AU - Aspelund, Thor
AU - Barroso, Ins
AU - Campbell, Harry
AU - Cassano, Patricia A.
AU - Couper, David J.
AU - Eiriksdottir, Gudny
AU - Franceschini, Nora
AU - Garcia, Melissa
AU - Gieger, Christian
AU - Gislason, Gauti Kjartan
AU - Grkovic, Ivica
AU - Hammond, Christopher J.
AU - Hancock, Dana B.
AU - Harris, Tamara B.
AU - Ramasamy, Adaikalavan
AU - Heckbert, Susan R.
AU - Heliövaara, Markku
AU - Homuth, Georg
AU - Hysi, Pirro G.
AU - James, Alan L.
AU - Jankovic, Stipan
AU - Joubert, Bonnie R.
AU - Karrasch, Stefan
AU - Klopp, Norman
AU - Koch, Beate
AU - Kritchevsky, Stephen B.
AU - Launer, Lenore J.
AU - Liu, Yongmei
AU - Loehr, Laura R.
AU - Lohman, Kurt
AU - Loos, Ruth J F
AU - Lumley, Thomas
AU - Al Balushi, Khalid A.
AU - Ang, Wei Q.
AU - Barr, R. Graham
AU - Beilby, John
AU - Blakey, John D.
AU - Boban, Mladen
AU - Boraska, Vesna
AU - Brisman, Jonas
AU - Britton, John R.
AU - Brusselle, Guy G.
AU - Cooper, Cyrus
AU - Curjuric, Ivan
AU - Dahgam, Santosh
AU - Deary, Ian J.
AU - Ebrahim, Shah
AU - Eijgelsheim, Mark
AU - Francks, Clyde
AU - Gaysina, Darya
AU - Granell, Raquel
AU - Gu, Xiangjun
AU - Hankinson, John L.
AU - Hardy, Rebecca
AU - Harris, Sarah E.
AU - Henderson, John
AU - Henry, Amanda
AU - Hingorani, Aroon D.
AU - Hofman, Albert
AU - Holt, Patrick G.
AU - Hui, Jennie
AU - Hunter, Michael L.
AU - Imboden, Medea
AU - Jameson, Karen A.
AU - Kerr, Shona M.
AU - Kolcic, Ivana
AU - Kronenberg, Florian
AU - Liu, Jason Z.
AU - Marchini, Jonathan
AU - McKeever, Tricia
AU - Morris, Andrew D.
AU - Olin, Anna Carin
AU - Porteous, David J.
AU - Postma, Dirkje S.
AU - Rich, Stephen S.
AU - Ring, Susan M.
AU - Rivadeneira, Fernando
AU - Rochat, Thierry
AU - Sayer, Avan Aihie
AU - Sayers, Ian
AU - Sly, Peter D.
AU - Smith, George Davey
AU - Sood, Akshay
AU - Starr, John M.
AU - Uitterlinden, André G.
AU - Vonk, Judith M.
AU - Wannamethee, S. Goya
AU - Whincup, Peter H.
AU - Wijmenga, Cisca
AU - Williams, O. Dale
AU - Wong, Andrew
AU - Mangino, Massimo
AU - Marciante, Kristin D.
AU - McArdle, Wendy L.
AU - Meibohm, Bernd
AU - Morrison, Alanna C.
AU - North, Kari E.
AU - Omenaas, Ernst
AU - Palmer, Lyle J.
AU - Pietiläinen, Kirsi H.
AU - Pin, Isabelle
AU - Polašek, Ozren
AU - Pouta, Anneli
AU - Psaty, Bruce M.
AU - Hartikainen, Anna Liisa
AU - Rantanen, Taina
AU - Ripatti, Samuli
AU - Rotter, Jerome I.
AU - Rudan, Igor
AU - Rudnicka, Alicja R.
AU - Schulz, Holger
AU - Shin, So Youn
AU - Spector, Tim D.
AU - Surakka, Ida
AU - Vitart, Veronique
AU - Völzke, Henry
AU - Wareham, Nicholas J.
AU - Warrington, Nicole M.
AU - Wichmann, H. Erich
AU - Wild, Sarah H.
AU - Wilk, Jemma B.
AU - Wjst, Matthias
AU - Wright, Alan F.
AU - Zgaga, Lina
AU - Zemunik, Tatijana
AU - Pennell, Craig E.
AU - Nyberg, Fredrik
AU - Kuh, Diana
AU - Holloway, John W.
AU - Boezen, H. Marike
AU - Lawlor, Debbie A.
AU - Morris, Richard W.
AU - Probst-Hensch, Nicole
AU - Kaprio, Jaakko
AU - Wilson, James F.
AU - Hayward, Caroline
AU - Kähönen, Mika
AU - Heinrich, Joachim
AU - Musk, Arthur W.
AU - Jarvis, Deborah L.
AU - Gläser, Sven
AU - Järvelin, Marjo Riitta
AU - Ch Stricker, Bruno H.
AU - Elliott, Paul
AU - O'Connor, George T.
AU - Strachan, David P.
AU - London, Stephanie J.
AU - Hall, Ian P.
AU - Gudnason, Vilmundur
AU - Tobin, Martin D.
PY - 2011/11
Y1 - 2011/11
N2 - Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P <5 ×-10-8) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function.
AB - Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P <5 ×-10-8) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function.
UR - http://www.scopus.com/inward/record.url?scp=80055008094&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80055008094&partnerID=8YFLogxK
U2 - 10.1038/ng.941
DO - 10.1038/ng.941
M3 - Article
C2 - 21946350
AN - SCOPUS:80055008094
VL - 43
SP - 1082
EP - 1090
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 11
ER -