Abstract
Isolates of Plasmodium falciparum from patients in a Sudanese village exhibiting RI resistance to chloroquine have been typed for allelic variants of 2 merozoite surface antigens, MSP1 and MSP2. Blood forms were taken from each patient before chloroquine was administered, and after parasites had reappeared following treatment. Each patient was found to be infected with genetically different parasites. However, in each patient the parasites of the recrudescent infections possessed the same alleles of each gene as those of the primary infection. The results show that the parasites which reappeared after chloroquine were a genuine recrudescence of the primary forms, and not derived from a new infection.
| Original language | English |
|---|---|
| Pages (from-to) | 328-331 |
| Number of pages | 4 |
| Journal | Transactions of the Royal Society of Tropical Medicine and Hygiene |
| Volume | 88 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1994 |
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ASJC Scopus subject areas
- Parasitology
- Medicine(all)
Cite this
Genetic evidence that RI chloroquine resistance of Plasmodium falciparum is caused by recrudescence of resistant parasites. / Babiker, Hamza; Ranford-Cartwright, Lisa; Sultan, Ali; Satti, Gwiria; Walliker, David.
In: Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol. 88, No. 3, 1994, p. 328-331.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Genetic evidence that RI chloroquine resistance of Plasmodium falciparum is caused by recrudescence of resistant parasites
AU - Babiker, Hamza
AU - Ranford-Cartwright, Lisa
AU - Sultan, Ali
AU - Satti, Gwiria
AU - Walliker, David
PY - 1994
Y1 - 1994
N2 - Isolates of Plasmodium falciparum from patients in a Sudanese village exhibiting RI resistance to chloroquine have been typed for allelic variants of 2 merozoite surface antigens, MSP1 and MSP2. Blood forms were taken from each patient before chloroquine was administered, and after parasites had reappeared following treatment. Each patient was found to be infected with genetically different parasites. However, in each patient the parasites of the recrudescent infections possessed the same alleles of each gene as those of the primary infection. The results show that the parasites which reappeared after chloroquine were a genuine recrudescence of the primary forms, and not derived from a new infection.
AB - Isolates of Plasmodium falciparum from patients in a Sudanese village exhibiting RI resistance to chloroquine have been typed for allelic variants of 2 merozoite surface antigens, MSP1 and MSP2. Blood forms were taken from each patient before chloroquine was administered, and after parasites had reappeared following treatment. Each patient was found to be infected with genetically different parasites. However, in each patient the parasites of the recrudescent infections possessed the same alleles of each gene as those of the primary infection. The results show that the parasites which reappeared after chloroquine were a genuine recrudescence of the primary forms, and not derived from a new infection.
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UR - http://www.scopus.com/inward/citedby.url?scp=0028341064&partnerID=8YFLogxK
U2 - 10.1016/0035-9203(94)90103-1
DO - 10.1016/0035-9203(94)90103-1
M3 - Article
VL - 88
SP - 328
EP - 331
JO - Transactions of the Royal Society of Tropical Medicine and Hygiene
JF - Transactions of the Royal Society of Tropical Medicine and Hygiene
SN - 0035-9203
IS - 3
ER -