Genetic evidence that RI chloroquine resistance of Plasmodium falciparum is caused by recrudescence of resistant parasites

Hamza Babiker; Lisa Ranford-Cartwright; Ali Sultan; Gwiria Satti; David Walliker

doi:10.1016/0035-9203(94)90103-1

Genetic evidence that RI chloroquine resistance of Plasmodium falciparum is caused by recrudescence of resistant parasites

Hamza Babiker^*, Lisa Ranford-Cartwright, Ali Sultan, Gwiria Satti, David Walliker

^*Corresponding author for this work

Biochemistry

Research output: Contribution to journal › Article › peer-review

51 Citations (Scopus)

Abstract

Isolates of Plasmodium falciparum from patients in a Sudanese village exhibiting RI resistance to chloroquine have been typed for allelic variants of 2 merozoite surface antigens, MSP1 and MSP2. Blood forms were taken from each patient before chloroquine was administered, and after parasites had reappeared following treatment. Each patient was found to be infected with genetically different parasites. However, in each patient the parasites of the recrudescent infections possessed the same alleles of each gene as those of the primary infection. The results show that the parasites which reappeared after chloroquine were a genuine recrudescence of the primary forms, and not derived from a new infection.

Original language	English
Pages (from-to)	328-331
Number of pages	4
Journal	Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume	88
Issue number	3
DOIs	https://doi.org/10.1016/0035-9203(94)90103-1
Publication status	Published - 1994

ASJC Scopus subject areas

Parasitology
Medicine(all)

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Genetic evidence that RI chloroquine resistance of Plasmodium falciparum is caused by recrudescence of resistant parasites. / Babiker, Hamza; Ranford-Cartwright, Lisa; Sultan, Ali; Satti, Gwiria; Walliker, David.

In: Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol. 88, No. 3, 1994, p. 328-331.

Research output: Contribution to journal › Article › peer-review

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abstract = "Isolates of Plasmodium falciparum from patients in a Sudanese village exhibiting RI resistance to chloroquine have been typed for allelic variants of 2 merozoite surface antigens, MSP1 and MSP2. Blood forms were taken from each patient before chloroquine was administered, and after parasites had reappeared following treatment. Each patient was found to be infected with genetically different parasites. However, in each patient the parasites of the recrudescent infections possessed the same alleles of each gene as those of the primary infection. The results show that the parasites which reappeared after chloroquine were a genuine recrudescence of the primary forms, and not derived from a new infection.",

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AU - Satti, Gwiria

AU - Walliker, David

PY - 1994

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AB - Isolates of Plasmodium falciparum from patients in a Sudanese village exhibiting RI resistance to chloroquine have been typed for allelic variants of 2 merozoite surface antigens, MSP1 and MSP2. Blood forms were taken from each patient before chloroquine was administered, and after parasites had reappeared following treatment. Each patient was found to be infected with genetically different parasites. However, in each patient the parasites of the recrudescent infections possessed the same alleles of each gene as those of the primary infection. The results show that the parasites which reappeared after chloroquine were a genuine recrudescence of the primary forms, and not derived from a new infection.

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Genetic evidence that RI chloroquine resistance of Plasmodium falciparum is caused by recrudescence of resistant parasites

Abstract

ASJC Scopus subject areas

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