TY - JOUR
T1 - Genetic evidence that RI chloroquine resistance of Plasmodium falciparum is caused by recrudescence of resistant parasites
AU - Babiker, Hamza
AU - Ranford-Cartwright, Lisa
AU - Sultan, Ali
AU - Satti, Gwiria
AU - Walliker, David
N1 - Funding Information:
Funding for this work has comef rom the UK Medical Re-searchC ouncil, the World Health Organizationa nd the USA National Instituteso f Health grant AI-16312.H amza Babiker and Ali Sultan are recipientso f British Council studentships. We appreciatep articularlyt he supporto f the Malaria Administration of the SudaneseM inistry of Health, togetherw ith the Malaria Committeein Gedaref.W e gratefullya cknowledgeth e assistanceo f Lars Hviid and Thor Theander,s upportedb y the Danish InternationaDl eveloomenAt aencv( DANIDA). as well as the greath elp of David Arnoi, Riad Biyoumi and JamesJ ensen. We thank especiallyt he peopleo f Asar villagef or their kind as-sistancea nd goodwilli n this project.
PY - 1994/5
Y1 - 1994/5
N2 - Isolates of Plasmodium falciparum from patients in a Sudanese village exhibiting RI resistance to chloroquine have been typed for allelic variants of 2 merozoite surface antigens, MSP1 and MSP2. Blood forms were taken from each patient before chloroquine was administered, and after parasites had reappeared following treatment. Each patient was foundto be infected with genetically different parasites. However, in each patient the parasites of the recrudescent infections possessed the same alleles of each gene as those of the primary infection. The results show that the parasites which reappeared after chloroquine were a genuine recrudescence of the primary forms, and not derived from a new infection.
AB - Isolates of Plasmodium falciparum from patients in a Sudanese village exhibiting RI resistance to chloroquine have been typed for allelic variants of 2 merozoite surface antigens, MSP1 and MSP2. Blood forms were taken from each patient before chloroquine was administered, and after parasites had reappeared following treatment. Each patient was foundto be infected with genetically different parasites. However, in each patient the parasites of the recrudescent infections possessed the same alleles of each gene as those of the primary infection. The results show that the parasites which reappeared after chloroquine were a genuine recrudescence of the primary forms, and not derived from a new infection.
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U2 - 10.1016/0035-9203(94)90103-1
DO - 10.1016/0035-9203(94)90103-1
M3 - Article
C2 - 7974680
AN - SCOPUS:0028341064
VL - 88
SP - 328
EP - 331
JO - Transactions of the Royal Society of Tropical Medicine and Hygiene
JF - Transactions of the Royal Society of Tropical Medicine and Hygiene
SN - 0035-9203
IS - 3
ER -