Genetic epidemiology of HbS in Oman: Multicentric origin for the β(s) gene

Shahina Daar, H. Mohamed Hussain, David Gravell, Ronald L. Nagel, Rajagopal Krishnamoorthy

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

On the basis of a sample of 117 chromosomes, we have demonstrated the multicentric origin of the sickle mutation in Northern Oman. Three major haplotypes coexist: 52.1% Benin (typical and atypicals), 26.7% Arab-India, and 21.4% Bantu. These haplotypes are not autochthonous to Oman but originated elsewhere and arrived in Oman by gene flow. The distribution of haplotypes is in excellent agreement with the historical record, which establishes clear ancient contacts between Oman and sub-Sahara west Africa and explains the presence of the Benin haplotype; contacts with Iraq, Iran, present-day Pakistan, and India explain the presence of the Arab-India haplotype. More recent contacts with East Africa (Zanzibar/Mombasa) explain the presence of the Bantu haplotype. The pattern of the Arab-India haplotype in the populations of the Arabian peninsula reinforces the hypothesis that this particular mutation originated in the Harappa culture or in a nearby population and in addition reveals that the Sassanian Empire might have been the vehicle by which this Indo-European sickle mutation migrated (gene flow) to the present-day Arabian peninsula, including Oman. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish
Pages (from-to)39-45
Number of pages7
JournalAmerican Journal of Hematology
Volume64
Issue number1
DOIs
Publication statusPublished - 2000

Fingerprint

Molecular Epidemiology
Oman
Haplotypes
India
Genes
Benin
Gene Flow
Mutation
Northern Africa
Eastern Africa
Iraq
Western Africa
Tanzania
Pakistan
Iran
hemoglobin S-Oman
Population
Chromosomes

Keywords

  • β(s) gene
  • HbS
  • Oman

ASJC Scopus subject areas

  • Hematology

Cite this

Genetic epidemiology of HbS in Oman : Multicentric origin for the β(s) gene. / Daar, Shahina; Mohamed Hussain, H.; Gravell, David; Nagel, Ronald L.; Krishnamoorthy, Rajagopal.

In: American Journal of Hematology, Vol. 64, No. 1, 2000, p. 39-45.

Research output: Contribution to journalArticle

Daar, Shahina ; Mohamed Hussain, H. ; Gravell, David ; Nagel, Ronald L. ; Krishnamoorthy, Rajagopal. / Genetic epidemiology of HbS in Oman : Multicentric origin for the β(s) gene. In: American Journal of Hematology. 2000 ; Vol. 64, No. 1. pp. 39-45.
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