TY - JOUR
T1 - Genetic epidemiology of HbS in Oman
T2 - Multicentric origin for the β(s) gene
AU - Daar, Shahina
AU - Mohamed Hussain, H.
AU - Gravell, David
AU - Nagel, Ronald L.
AU - Krishnamoorthy, Rajagopal
PY - 2000
Y1 - 2000
N2 - On the basis of a sample of 117 chromosomes, we have demonstrated the multicentric origin of the sickle mutation in Northern Oman. Three major haplotypes coexist: 52.1% Benin (typical and atypicals), 26.7% Arab-India, and 21.4% Bantu. These haplotypes are not autochthonous to Oman but originated elsewhere and arrived in Oman by gene flow. The distribution of haplotypes is in excellent agreement with the historical record, which establishes clear ancient contacts between Oman and sub-Sahara west Africa and explains the presence of the Benin haplotype; contacts with Iraq, Iran, present-day Pakistan, and India explain the presence of the Arab-India haplotype. More recent contacts with East Africa (Zanzibar/Mombasa) explain the presence of the Bantu haplotype. The pattern of the Arab-India haplotype in the populations of the Arabian peninsula reinforces the hypothesis that this particular mutation originated in the Harappa culture or in a nearby population and in addition reveals that the Sassanian Empire might have been the vehicle by which this Indo-European sickle mutation migrated (gene flow) to the present-day Arabian peninsula, including Oman. (C) 2000 Wiley-Liss, Inc.
AB - On the basis of a sample of 117 chromosomes, we have demonstrated the multicentric origin of the sickle mutation in Northern Oman. Three major haplotypes coexist: 52.1% Benin (typical and atypicals), 26.7% Arab-India, and 21.4% Bantu. These haplotypes are not autochthonous to Oman but originated elsewhere and arrived in Oman by gene flow. The distribution of haplotypes is in excellent agreement with the historical record, which establishes clear ancient contacts between Oman and sub-Sahara west Africa and explains the presence of the Benin haplotype; contacts with Iraq, Iran, present-day Pakistan, and India explain the presence of the Arab-India haplotype. More recent contacts with East Africa (Zanzibar/Mombasa) explain the presence of the Bantu haplotype. The pattern of the Arab-India haplotype in the populations of the Arabian peninsula reinforces the hypothesis that this particular mutation originated in the Harappa culture or in a nearby population and in addition reveals that the Sassanian Empire might have been the vehicle by which this Indo-European sickle mutation migrated (gene flow) to the present-day Arabian peninsula, including Oman. (C) 2000 Wiley-Liss, Inc.
KW - HbS
KW - Oman
KW - β(s) gene
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U2 - 10.1002/(sici)1096-8652(200005)64:1<39::aid-ajh7>3.0.co;2-%23
DO - 10.1002/(sici)1096-8652(200005)64:1<39::aid-ajh7>3.0.co;2-%23
M3 - Article
C2 - 10815786
AN - SCOPUS:0342369587
SN - 0361-8609
VL - 64
SP - 39
EP - 46
JO - American Journal of Hematology
JF - American Journal of Hematology
IS - 1
ER -