Genetic diversity of Plasmodium falciparum in a village in eastern Sudan. 1. Diversity of enzymes, 2D-PAGE proteins and antigens

Hamza Ali Babiker, Alison M. Creasey, Brian Fenton, Riad A L Bayoumi, David E. Arnot, David Walliker

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Abstract

Twenty-nine Plasmodium falciparum isolates from patients in Asar village, eastern Sudan, were characterized for variation in 18 different genetically controlled characters, including iso-enzymes, proteins detected by two-dimensional polyacrylamide gel electrophoresis and blood-stage antigens. Considerable allelic diversity in the genes determining these characters was detected. Each isolate contained genetically distinct parasites. Fifteen individuals were infected with more than one parasite genotype. The diversity of parasite types is most probably generated by recombination during mosquito transmission of mixed parasite clones.

Original languageEnglish
Pages (from-to)572-577
Number of pages6
JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
Volume85
Issue number5
DOIs
Publication statusPublished - 1991

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ASJC Scopus subject areas

  • Parasitology
  • Medicine(all)

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