TY - JOUR
T1 - Genetic diversity of Plasmodium falciparum in a village in eastern Sudan. 1. Diversity of enzymes, 2D-PAGE proteins and antigens
AU - Babiker, Hamza Ali
AU - Creasey, Alison M.
AU - Fenton, Brian
AU - Bayoumi, Riad A.L.
AU - Arnot, David E.
AU - Walliker, David
N1 - Funding Information:
Acknowledeements We acknowledge with gratitude continuing support from the Medical Research Council of Great Britain? The Wellcome Trust, and the World Health Organization (TDR). Richard Fawcett provided expert technical assistance in culturing parasites. Field studies in Sudan arc generously funded by grants from the National Institutes of Health, USA (AI-16312) and the Danish Agency for International Development (DANIDA). We particularly thank Dr James Jensen for valuable assistance and encouragement. Hamza Babiker is supported by funds from the Overseas Development Administration of Great Britain, administered by the British Council. The work would not have been possible without the help of the Malaria Administration of Sudan. We are also happy to acknowledge the goodwill and excellent co-operation of the staff of Gedaref Hospital and the people of Asar.
PY - 1991
Y1 - 1991
N2 - Twenty-nine Plasmodium falciparum isolates from patients in Asar village, eastern Sudan, were characterized for variation in 18 different genetically controlled characters, including iso-enzymes, proteins detected by two-dimensional polyacrylamide gel electrophoresis and blood-stage antigens. Considerable allelic diversity in the genes determining these characters was detected. Each isolate contained genetically distinct parasites. Fifteen individuals were infected with more than one parasite genotype. The diversity of parasite types is most probably generated by recombination during mosquito transmission of mixed parasite clones.
AB - Twenty-nine Plasmodium falciparum isolates from patients in Asar village, eastern Sudan, were characterized for variation in 18 different genetically controlled characters, including iso-enzymes, proteins detected by two-dimensional polyacrylamide gel electrophoresis and blood-stage antigens. Considerable allelic diversity in the genes determining these characters was detected. Each isolate contained genetically distinct parasites. Fifteen individuals were infected with more than one parasite genotype. The diversity of parasite types is most probably generated by recombination during mosquito transmission of mixed parasite clones.
UR - http://www.scopus.com/inward/record.url?scp=0026001603&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026001603&partnerID=8YFLogxK
U2 - 10.1016/0035-9203(91)90347-2
DO - 10.1016/0035-9203(91)90347-2
M3 - Article
C2 - 1780978
AN - SCOPUS:0026001603
SN - 0035-9203
VL - 85
SP - 572
EP - 577
JO - Transactions of the Royal Society of Tropical Medicine and Hygiene
JF - Transactions of the Royal Society of Tropical Medicine and Hygiene
IS - 5
ER -
