Genetic complexity and gametocyte production of Plasmodium falciparum in Fulani and Mossi communities in Burkina Faso

G. M. Paganotti, C. Palladino, D. Modiano, B. S. Sirima, L. Råberg, A. Diarra, A. Konaté, M. Coluzzi, D. Walliker, H. A. Babiker

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

We have examined Plasmodium falciparum gametocyte prevalence, density and their genetic complexity among children of 2 sympatric ethnic groups (Mossi and Fulani) in villages in Burkina Faso. The 2 groups are known to have distinct differences in their susceptibility and immune responses to malaria. We used RT-PCR and sequence-specific probes to detect and type RNA of the gametocyte-specific protein Pfs48/45. There were no differences in detection rates of asexual forms and gametocytes among the 2 groups, using PCR and RT-PCR, respectively. However, there were significant differences in densities of asexual forms and gametocytes, which were both higher among Mossi than Fulani. Both asexual forms and gametocyte densities were influenced by age and ethnicity. Multiple-clone infections with more than 1 gametocyte genotype were equally prevalent among Fulani and Mossi. These differences can most probably be attributed to genetic differences in malaria susceptibility in the 2 ethnic groups.

Original languageEnglish
Pages (from-to)607-614
Number of pages8
JournalParasitology
Volume132
Issue number5
DOIs
Publication statusPublished - 2006

Fingerprint

Burkina Faso
gametocytes
Plasmodium falciparum
Ethnic Groups
Polymerase Chain Reaction
Malaria
nationalities and ethnic groups
malaria
Clone Cells
reverse transcriptase polymerase chain reaction
Genotype
RNA
Infection
villages
Proteins
immune response
clones
genotype
infection

Keywords

  • Burkina Faso
  • Fulani
  • Gametocytes
  • Mossi
  • Plasmodium falciparum

ASJC Scopus subject areas

  • Parasitology
  • Immunology

Cite this

Genetic complexity and gametocyte production of Plasmodium falciparum in Fulani and Mossi communities in Burkina Faso. / Paganotti, G. M.; Palladino, C.; Modiano, D.; Sirima, B. S.; Råberg, L.; Diarra, A.; Konaté, A.; Coluzzi, M.; Walliker, D.; Babiker, H. A.

In: Parasitology, Vol. 132, No. 5, 2006, p. 607-614.

Research output: Contribution to journalArticle

Paganotti, GM, Palladino, C, Modiano, D, Sirima, BS, Råberg, L, Diarra, A, Konaté, A, Coluzzi, M, Walliker, D & Babiker, HA 2006, 'Genetic complexity and gametocyte production of Plasmodium falciparum in Fulani and Mossi communities in Burkina Faso', Parasitology, vol. 132, no. 5, pp. 607-614. https://doi.org/10.1017/S0031182005009601
Paganotti, G. M. ; Palladino, C. ; Modiano, D. ; Sirima, B. S. ; Råberg, L. ; Diarra, A. ; Konaté, A. ; Coluzzi, M. ; Walliker, D. ; Babiker, H. A. / Genetic complexity and gametocyte production of Plasmodium falciparum in Fulani and Mossi communities in Burkina Faso. In: Parasitology. 2006 ; Vol. 132, No. 5. pp. 607-614.
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