Gene frequencies of human platelet alloantigens in Bahraini Arabs

Abeer M. Al-Subaie, Iman K. Al-Absi, Khadija Al-Ola, Sarra Saidi, Naglaa A. Fawaz, Wassim Y. Almawi

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Abstract

Human platelet antigens (HPA) are implicated in the pathophysiology of certain hematological disorders, and as varied distribution of HPA-1 alleles and genotypes were reported for different countries and ethnic populations, we determined the distribution of HPA-1, -2, -3, -4, and -5 alleles, genotypes and haplotypes for 194 healthy Bahraini subjects by polymerase chain reaction with sequence specific primers. The distribution of the HPA polymorphisms was in Hardy-Weinberg equilibrium. Allele frequencies of 0.76 and 0.24 (HPA-1a and -1b), 0.77 and 0.23 (HPA-2a and -2b), 0.57 and 0.43 (HPA-3a and -3b), 0.93 and 0.07 (HPA-4a and -4b), and 0.86 and 0.13 (HPA-5a and -5b) were seen. With the exception of HPA-3a/a (30.4%), the frequencies of homozygous HPA-1a/a (56.8%), 2a/a (60.1%), 4a/a (87.2%), and 5a/a (75.7%) were higher than those of heterozygous (a/b) or homozygous (b/b) variants. Our results provide basic information for further studies of the HPA system polymorphism, which in turn will be instrumental in understanding and treating immune-mediated platelet disorders.

Original languageEnglish
Pages (from-to)242-244
Number of pages3
JournalAmerican Journal of Hematology
Volume82
Issue number3
DOIs
Publication statusPublished - Mar 2007

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Keywords

  • Haplotype
  • Hematological disorders
  • Human platelet antigens
  • PCR-SSP

ASJC Scopus subject areas

  • Hematology

Cite this

Al-Subaie, A. M., Al-Absi, I. K., Al-Ola, K., Saidi, S., Fawaz, N. A., & Almawi, W. Y. (2007). Gene frequencies of human platelet alloantigens in Bahraini Arabs. American Journal of Hematology, 82(3), 242-244. https://doi.org/10.1002/ajh.20769