Gene flow and cross-mating in Plasmodium falciparum in households in a Tanzanian village

H. A. Babiker, J. D. Charlwood, T. Smith, D. Walliker

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The diversity of the genes encoding 2 merozoite surface proteins (MSP-1 and MSP-2) of Plasmodium falciparum has been examined in parasites infecting members of 4 households in a village in Tanzania. The polymerase chain reaction (PCR) was used to characterize allelic variants of these genes by the sizes and sequences of regions of tandemly repeated bases in each gene. In each household extensive polymorphism was detected among parasites in the inhabitants and in infected mosquitoes caught in their houses. Similar frequencies of the alleles of these genes were observed in all households. Capture-recapture data indicated that both Anopheles gambiae and A. funestus freely dispersed among households in the hamlet. The results confirm that cross-mating and gene flow occur extensively among the parasites, and are discussed within the contest of spatial clustering of natural populations of P. falciparum.

Original languageEnglish
Pages (from-to)433-442
Number of pages10
JournalParasitology
Volume111
Issue number4
Publication statusPublished - 1995

Fingerprint

Gene Flow
Plasmodium falciparum
villages
households
gene flow
Merozoite Surface Protein 1
Parasites
Gene Frequency
parasites
genes
Anopheles funestus
Genes
Anopheles gambiae
merozoites
Tanzania
surface proteins
Culicidae
gene frequency
Cluster Analysis
polymerase chain reaction

Keywords

  • Genetic polymorphisms
  • Merozoite surface proteins
  • Plasmodium falciparum
  • Spatial clustering

ASJC Scopus subject areas

  • Immunology
  • Parasitology

Cite this

Gene flow and cross-mating in Plasmodium falciparum in households in a Tanzanian village. / Babiker, H. A.; Charlwood, J. D.; Smith, T.; Walliker, D.

In: Parasitology, Vol. 111, No. 4, 1995, p. 433-442.

Research output: Contribution to journalArticle

Babiker, HA, Charlwood, JD, Smith, T & Walliker, D 1995, 'Gene flow and cross-mating in Plasmodium falciparum in households in a Tanzanian village', Parasitology, vol. 111, no. 4, pp. 433-442.
Babiker, H. A. ; Charlwood, J. D. ; Smith, T. ; Walliker, D. / Gene flow and cross-mating in Plasmodium falciparum in households in a Tanzanian village. In: Parasitology. 1995 ; Vol. 111, No. 4. pp. 433-442.
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