TY - JOUR
T1 - Gastric adenocarcinoma in association with tuberous sclerosis case report
AU - Ahmed, Saeed
AU - Burney, Ikram
AU - Sawhney, Sukhpal
AU - Al-Moundhri, Mansour S.
N1 - Publisher Copyright:
© 2009, Sultan Qaboos University. All rights reserved.
PY - 2009/4
Y1 - 2009/4
N2 - We report the first case of gastric cancer in association with tuberous sclerosis. Tuberous sclerosis is an autosomal dominant disorder which presents with a constellation of signs including benign tumours in the brain and in other vital organs such as the kidneys, heart, eyes, lungs, and skin. A combination of symptoms may include seizures, developmental delay, behavioural problems, skin abnormalities, and lung and kidney disease. It is caused by mutations on either of two genes, tuberous sclerosis genes, TSC1 or TSC2, which encode for the proteins hamartin and tuberin respectively. These proteins act as tumour growth suppressor agents that regulate cell proliferation and differentiation. Tuberous sclerosis has been associated with hamartomatous growths and angiomyol-ipomas, an association with gastric cancer has not been reported; however, this could be a co-incidental finding and further cases need to be reported.
AB - We report the first case of gastric cancer in association with tuberous sclerosis. Tuberous sclerosis is an autosomal dominant disorder which presents with a constellation of signs including benign tumours in the brain and in other vital organs such as the kidneys, heart, eyes, lungs, and skin. A combination of symptoms may include seizures, developmental delay, behavioural problems, skin abnormalities, and lung and kidney disease. It is caused by mutations on either of two genes, tuberous sclerosis genes, TSC1 or TSC2, which encode for the proteins hamartin and tuberin respectively. These proteins act as tumour growth suppressor agents that regulate cell proliferation and differentiation. Tuberous sclerosis has been associated with hamartomatous growths and angiomyol-ipomas, an association with gastric cancer has not been reported; however, this could be a co-incidental finding and further cases need to be reported.
KW - Case report
KW - Gastric cancer
KW - Hamartoma
KW - Lymphangiomyomatosis
KW - Mucinous adenocarcinoma
KW - Oman
KW - Tuberous sclerosis
UR - http://www.scopus.com/inward/record.url?scp=84887908905&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84887908905&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:84887908905
SN - 2075-051X
VL - 9
SP - 75
EP - 78
JO - Sultan Qaboos University Medical Journal
JF - Sultan Qaboos University Medical Journal
IS - 1
ER -