Further evidence for papovavirus as the probable etiology of transmissible lymphoma of Syrian hamsters.

S. W. Barthold, P. N. Bhatt, E. A. Johnson

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The role of hamster papovavirus as the etiology of transmissible lymphoma was investigated under strict conditions that prevented natural exposure to the lymphoma agent. In an initial experiment, 19 hamsters that were exposed naturally to transmissible lymphoma were placed in direct and indirect contact with weanling hamsters from an uninfected source. Lymphoma developed in the original infected hamsters as well as hamsters maintained in direct and indirect contact. In addition, one of the contact hamsters developed cutaneous epitheliomas, containing hamster papovavirus. Epithelioma homogenate was inoculated into primary hamster embryo cultures, in which hamster papovavirus replicated. Second and third passage tissue culture fluid containing hamster papovavirus induced lymphomas in suckling and weanling hamsters. Cell culture fluid from uninoculated embryo cultures was not oncogenic.

Original languageEnglish
Pages (from-to)283-288
Number of pages6
JournalLaboratory animal science Chicago
Volume37
Issue number3
Publication statusPublished - Jun 1987

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Hamster polyomavirus
Mesocricetus
lymphoma
Cell culture
hamsters
Cricetinae
etiology
Lymphoma
Tissue culture
Fluids
indirect contact
embryo culture
direct contact
weanlings
Experiments
Mesocricetus auratus
Embryonic Structures
suckling
tissue culture
Carcinoma

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Further evidence for papovavirus as the probable etiology of transmissible lymphoma of Syrian hamsters. / Barthold, S. W.; Bhatt, P. N.; Johnson, E. A.

In: Laboratory animal science Chicago, Vol. 37, No. 3, 06.1987, p. 283-288.

Research output: Contribution to journalArticle

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