Furosemide kinetics in camels (Camelus dromedarius)

G. Alhadrami, B. H. Ali, Y. Wong, A. K. Bashir, B. G. Charles

Research output: Contribution to journalArticle

Abstract

Furosemide kinetics was studied in camels (Camelus dromedarms). The drug was injected intramuscularly (i.m.) and intravenously (i.v.) at doses of 0.5 mg/kg or 1.5 mg/kg. The mean terminal elimination half life ranged from 50.2 min (0.5 mg/kg, i.m.) to 119 min (1.5 mg/kg, i.v.). The average systemic clearance and the steady state volume of distribution were higher when the 1.5 mg/kg dose was administered. Peak furosemide plasma concentration was achieved in about 20 min after i.m. dosing. The glucuronide metabolite of furosemide was not detected in plasma. The mean absolute bioavailability of furosemide administered i.m. ranged from 47% (0.5 mg/kg) to 71% (1.5 mg/kg). It appears that some aspects of the kinetics of furosemide in camels may be different from that in other animals such as the horse.

Original languageEnglish
JournalFASEB Journal
Volume11
Issue number3
Publication statusPublished - 1997

Fingerprint

furosemide
Camelus
Camelus dromedarius
Furosemide
camels
kinetics
Kinetics
Plasmas
Biological Availability
Horses
Glucuronides
Half-Life
Metabolites
dosage
half life
bioavailability
Animals
metabolites
horses
drugs

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Alhadrami, G., Ali, B. H., Wong, Y., Bashir, A. K., & Charles, B. G. (1997). Furosemide kinetics in camels (Camelus dromedarius). FASEB Journal, 11(3).

Furosemide kinetics in camels (Camelus dromedarius). / Alhadrami, G.; Ali, B. H.; Wong, Y.; Bashir, A. K.; Charles, B. G.

In: FASEB Journal, Vol. 11, No. 3, 1997.

Research output: Contribution to journalArticle

Alhadrami, G, Ali, BH, Wong, Y, Bashir, AK & Charles, BG 1997, 'Furosemide kinetics in camels (Camelus dromedarius)', FASEB Journal, vol. 11, no. 3.
Alhadrami G, Ali BH, Wong Y, Bashir AK, Charles BG. Furosemide kinetics in camels (Camelus dromedarius). FASEB Journal. 1997;11(3).
Alhadrami, G. ; Ali, B. H. ; Wong, Y. ; Bashir, A. K. ; Charles, B. G. / Furosemide kinetics in camels (Camelus dromedarius). In: FASEB Journal. 1997 ; Vol. 11, No. 3.
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