Functional mutations of the ABCA1 gene in subjects of French-Canadian descent with HDL deficiency

Khalid Alrasadi, Isabelle L. Ruel, Michel Marcil, Jacques Genest

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Mutations in the ABCA1 gene cause defective cellular lipid efflux and severe familial HDL deficiency. We examined the prevalence of mutations at the ABCA1 gene in 58 unrelated probands of French-Canadian descent with HDL deficiency (HDL-C <5th percentile). A defective cellular cholesterol or phospholipid efflux (

Original languageEnglish
Pages (from-to)281-291
Number of pages11
JournalAtherosclerosis
Volume188
Issue number2
DOIs
Publication statusPublished - Oct 2006

Fingerprint

Mutation
Genes
Phospholipids
Cholesterol
Lipids
Familial HDL deficiency

Keywords

  • ABCA1
  • Cellular cholesterol and phospholipid efflux
  • Familial HDL deficiency
  • Gene defects

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Functional mutations of the ABCA1 gene in subjects of French-Canadian descent with HDL deficiency. / Alrasadi, Khalid; Ruel, Isabelle L.; Marcil, Michel; Genest, Jacques.

In: Atherosclerosis, Vol. 188, No. 2, 10.2006, p. 281-291.

Research output: Contribution to journalArticle

Alrasadi, Khalid ; Ruel, Isabelle L. ; Marcil, Michel ; Genest, Jacques. / Functional mutations of the ABCA1 gene in subjects of French-Canadian descent with HDL deficiency. In: Atherosclerosis. 2006 ; Vol. 188, No. 2. pp. 281-291.
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