Abstract
Mutations in the ABCA1 gene cause defective cellular lipid efflux and severe familial HDL deficiency. We examined the prevalence of mutations at the ABCA1 gene in 58 unrelated probands of French-Canadian descent with HDL deficiency (HDL-C <5th percentile). A defective cellular cholesterol or phospholipid efflux (
Original language | English |
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Pages (from-to) | 281-291 |
Number of pages | 11 |
Journal | Atherosclerosis |
Volume | 188 |
Issue number | 2 |
DOIs | |
Publication status | Published - Oct 2006 |
Keywords
- ABCA1
- Cellular cholesterol and phospholipid efflux
- Familial HDL deficiency
- Gene defects
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine