Functional connectivity of insular efferences

Talal Almashaikhi, Sylvain Rheims, Julien Jung, Karine Ostrowsky-Coste, Alexandra Montavont, Julitta De Bellescize, Alexis Arzimanoglou, Pascale Keo Kosal, Marc Guénot, Olivier Bertrand, Philippe Ryvlin

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Objectives: The aim of our study was to explore the functional connectivity between the insula and other cortical regions, in human, using cortico-cortical evoked potentials (CCEPs) Experimental design: We performed intra-cerebral electrical stimulation in eleven patients with refractory epilepsy investigated with depth electrodes, including 39 targeting the insula. Electrical stimulation consisted of two series of 20 pulses of 1-ms duration, 0.2-Hz frequency, and 1-mA intensity delivered at each of the 39 insular bipoles. Rates of connectivity were reported whenever a noninsular cortical region was tested by at least ten stimulating/recording electrode pairs in three or more patients Results: Significant CCEPs were elicited in 193 of the 578 (33%) tested connections, with an average latency of 33±5 ms. The highest connectivity rates were observed with the nearby perisylvian structures (59%), followed by the pericentral cortex (38%), the temporal neocortex (28%), the lateral parietal cortex (26%), the orbitofrontal cortex (25%), the mesial temporal structures (24%), the dorsolateral frontal cortex (15%), the temporal pole (14%), and the mesial parietal cortex (11%). No connectivity was detected in the mesial frontal cortex or cingulate gyrus. The pattern of connectivity also differed between the five insular gyri, with greater connectivity rate for the posterior short gyrus (49%), than for the middle short (29%), and two long gyri (28 and 33%) Conclusion: The human insula is characterized by a rich and complex connectivity that varies as a function of the insular gyrus and appears to partly differ from the efferences described in nonhuman primates.

Original languageEnglish
Pages (from-to)5279-5294
Number of pages16
JournalHuman Brain Mapping
Volume35
Issue number10
DOIs
Publication statusPublished - 2014

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Parietal Lobe
Frontal Lobe
Evoked Potentials
Electric Stimulation
Electrodes
Neocortex
Gyrus Cinguli
Temporal Lobe
Prefrontal Cortex
Primates
Epilepsy
Research Design

Keywords

  • Evoked potential
  • Functional connectivity
  • Human
  • Insular
  • Intra-cranial electrical stimulation

ASJC Scopus subject areas

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology

Cite this

Almashaikhi, T., Rheims, S., Jung, J., Ostrowsky-Coste, K., Montavont, A., De Bellescize, J., ... Ryvlin, P. (2014). Functional connectivity of insular efferences. Human Brain Mapping, 35(10), 5279-5294. https://doi.org/10.1002/hbm.22549

Functional connectivity of insular efferences. / Almashaikhi, Talal; Rheims, Sylvain; Jung, Julien; Ostrowsky-Coste, Karine; Montavont, Alexandra; De Bellescize, Julitta; Arzimanoglou, Alexis; Kosal, Pascale Keo; Guénot, Marc; Bertrand, Olivier; Ryvlin, Philippe.

In: Human Brain Mapping, Vol. 35, No. 10, 2014, p. 5279-5294.

Research output: Contribution to journalArticle

Almashaikhi, T, Rheims, S, Jung, J, Ostrowsky-Coste, K, Montavont, A, De Bellescize, J, Arzimanoglou, A, Kosal, PK, Guénot, M, Bertrand, O & Ryvlin, P 2014, 'Functional connectivity of insular efferences', Human Brain Mapping, vol. 35, no. 10, pp. 5279-5294. https://doi.org/10.1002/hbm.22549
Almashaikhi T, Rheims S, Jung J, Ostrowsky-Coste K, Montavont A, De Bellescize J et al. Functional connectivity of insular efferences. Human Brain Mapping. 2014;35(10):5279-5294. https://doi.org/10.1002/hbm.22549
Almashaikhi, Talal ; Rheims, Sylvain ; Jung, Julien ; Ostrowsky-Coste, Karine ; Montavont, Alexandra ; De Bellescize, Julitta ; Arzimanoglou, Alexis ; Kosal, Pascale Keo ; Guénot, Marc ; Bertrand, Olivier ; Ryvlin, Philippe. / Functional connectivity of insular efferences. In: Human Brain Mapping. 2014 ; Vol. 35, No. 10. pp. 5279-5294.
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abstract = "Objectives: The aim of our study was to explore the functional connectivity between the insula and other cortical regions, in human, using cortico-cortical evoked potentials (CCEPs) Experimental design: We performed intra-cerebral electrical stimulation in eleven patients with refractory epilepsy investigated with depth electrodes, including 39 targeting the insula. Electrical stimulation consisted of two series of 20 pulses of 1-ms duration, 0.2-Hz frequency, and 1-mA intensity delivered at each of the 39 insular bipoles. Rates of connectivity were reported whenever a noninsular cortical region was tested by at least ten stimulating/recording electrode pairs in three or more patients Results: Significant CCEPs were elicited in 193 of the 578 (33{\%}) tested connections, with an average latency of 33±5 ms. The highest connectivity rates were observed with the nearby perisylvian structures (59{\%}), followed by the pericentral cortex (38{\%}), the temporal neocortex (28{\%}), the lateral parietal cortex (26{\%}), the orbitofrontal cortex (25{\%}), the mesial temporal structures (24{\%}), the dorsolateral frontal cortex (15{\%}), the temporal pole (14{\%}), and the mesial parietal cortex (11{\%}). No connectivity was detected in the mesial frontal cortex or cingulate gyrus. The pattern of connectivity also differed between the five insular gyri, with greater connectivity rate for the posterior short gyrus (49{\%}), than for the middle short (29{\%}), and two long gyri (28 and 33{\%}) Conclusion: The human insula is characterized by a rich and complex connectivity that varies as a function of the insular gyrus and appears to partly differ from the efferences described in nonhuman primates.",
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