Frontotemporal dementia in Oman: Cognitive behavioural profile and neuroimaging characteristics; A prospective hospital-based study

Bhaskara P. Shelley, Jaber Al-Khabouri, Samir S. Hussein, Sameer B. Raniga

Research output: Contribution to journalArticle

5 Citations (Scopus)


Frontotemporal dementia is increasingly recognised as an important cause of early-onset dementia and is considered to be the second commonest neurodegenerative dementia after Alzheimer's disease. We describe the cognitive, behavioural profile and neuroimaging characteristics of 6 patients with frontal variant of Frontotemporal dementia that were evaluated at the cognitive behavioural clinic at this tertiary referral teaching hospital. All patients underwent clinical, neuropsychological, structural/functional neuroimaging, and laboratory evaluations. The male to female ratio was 1:1; mean age of onset was 54 years, and the mean duration of symptoms were 30 months. The mean scores for Addenbrooke's cognitive examination, Frontal Assessment Battery, and Mini-Mental State Examination were 70.5, 6.33 and 23.6 respectively. The mean VLOM ratio was 2.04. MRI revealed significant asymmetrical regional frontal/temporal atrophy supplemented by the evidence of circumscribed hypoperfusion in SPECT imaging. We conclude that a combination of behavioural and cognitive assessment using short bedside tests, along with structural and functional neuroimaging does facilitate early identification, and increase the diagnostic specificity of Frontotemporal dementia.

Original languageEnglish
Pages (from-to)167-174
Number of pages8
JournalJournal of the Neurological Sciences
Issue number1-2
Publication statusPublished - Sep 15 2007



  • Addenbrooke's Cognitive Examination
  • Early onset dementia
  • Frontal Assessment Battery
  • Frontal-variant
  • Frontotemporal dementia
  • MRI
  • Oman

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this