Fresh frozen plasma (Octaplas) and topical heparin in the management of ligneous conjunctivitis

Patrick Watts, Shahab H. Agha, Maha Mameesh, Phillip Conor, Anuradha Ganesh, Abdullah Al-Mujaini, Hugh Jewsbury, Anil Pathare, Abdulhakim AL-Rawas

Research output: Contribution to journalArticle

Abstract

Ligneous conjunctivitis is a rare form of chronic recurrent membranous conjunctivitis with reduced plasminogen activity. It is characterized by the formation of characteristic firm (“woody”) membranes on the tarsal conjunctiva. Similar lesions may occur on other mucous membranes. When treated with local excision, ligneous conjunctivitis is invariably associated with recurrences. Various therapeutic modalities, including topical heparin, cyclosporine, fresh frozen plasma (FFP), plasminogen, and amniotic membrane transplantation have been reported to reduce postoperative recurrences. We present 2 cases of recurrent ligneous conjunctivitis in children successfully managed with surgical excision under cover of FFP transfusion, amniotic membrane grafting, and combined with concomitant postoperative administration of topical heparin, steroids.

Original languageEnglish
JournalJournal of AAPOS
DOIs
Publication statusAccepted/In press - Jan 1 2018

Fingerprint

Heparin
Amnion
Plasminogen
Topical Administration
Recurrence
Conjunctivitis
Conjunctiva
Cyclosporine
Mucous Membrane
Transplantation
Steroids
Cell Membrane
Membranes
Type I Plasminogen Deficiency
Therapeutics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Ophthalmology

Cite this

Fresh frozen plasma (Octaplas) and topical heparin in the management of ligneous conjunctivitis. / Watts, Patrick; Agha, Shahab H.; Mameesh, Maha; Conor, Phillip; Ganesh, Anuradha; Al-Mujaini, Abdullah; Jewsbury, Hugh; Pathare, Anil; AL-Rawas, Abdulhakim.

In: Journal of AAPOS, 01.01.2018.

Research output: Contribution to journalArticle

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