Frequency of CYP2C9 genotypes among Omani patients receiving warfarin and its correlation with warfarin dose

Musbah O. Tanira, Mohammed K. Al-Mukhaini, Ali T. Al-Hinai, Khalid A. Al Balushi, Ikhlas S. Ahmed

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Objectives: This study was conducted to determine the frequency of CYP2C9 alleles in Omani patients receiving warfarin and to correlate genotyping data with warfarin dosage. The Omani population has Asian and African ethnicities. Methods: CYP2C9 genotypes were determined by the polymerase chain reaction restriction fragment length polymorphism method. Non-parametric Kruskal-Wallis test was used to compare groups of continuous data for significance differences. Results: Genotyping data showed that 12.7 and 5.8% of the samples were heterozygous for the CYP2C9*2 and CYP2C9*3 alleles, respectively. The CYP2C9*2 allele frequency was 0.074 in our population. It was 0.029 for CYP2C9*3. Conclusion: This is the first report on the presence of CYP2C9*2 allele homozygocity in any Asian or African population.

Original languageEnglish
Pages (from-to)32-37
Number of pages6
JournalCommunity Genetics
Volume10
Issue number1
DOIs
Publication statusPublished - Dec 2006

Keywords

  • CYP2C9 genotype
  • Warfarin treatment

ASJC Scopus subject areas

  • Genetics(clinical)

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