TY - JOUR
T1 - Folate and vitamin B12 deficiency and hyperhomocysteinemia promote oxidative stress in adult type 2 diabetes
AU - Al-Maskari, Masoud Y.
AU - Waly, Mostafa I.
AU - Ali, Amanat
AU - Al-Shuaibi, Yusra S.
AU - Ouhtit, Allal
N1 - Funding Information:
This study was financially supported in part by The Sultan Qaboos University internal grant IG/AGR/FOOD/10/01 .
PY - 2012/7
Y1 - 2012/7
N2 - Objective: The purpose of this study was to examine the status of folate and vitamin B12 (B12) in relation to serum homocysteine (HCY) and oxidative stress indices in patients with type 2 diabetes (T2DM). Methods: This case-control study involved 100 Omani adults (50 patients newly diagnosed with T2DM and 50 age- and gender-matched healthy controls). Several parameters were investigated, including dietary intake and biochemical assessments of folate, B12, HCY, oxidative stress markers (glutathione and total antioxidant status), and antioxidant enzymes (superoxide dismutase, glutathione peroxidase, and catalase). Results: Low serum levels of folate, B12, and hyperhomocysteinemia were prevalent in patients with T2DM compared with controls. Oxidative stress was evident in patients with T2DM as indicated by low serum levels of glutathione, total antioxidant status, and impaired antioxidant enzymatic activities (superoxide dismutase, glutathione peroxidase, and catalase). Conclusion: The low intake of folate and B12 is associated with low serum levels of these two nutrients and hyperhomocysteinemia in Omani adults with T2DM.
AB - Objective: The purpose of this study was to examine the status of folate and vitamin B12 (B12) in relation to serum homocysteine (HCY) and oxidative stress indices in patients with type 2 diabetes (T2DM). Methods: This case-control study involved 100 Omani adults (50 patients newly diagnosed with T2DM and 50 age- and gender-matched healthy controls). Several parameters were investigated, including dietary intake and biochemical assessments of folate, B12, HCY, oxidative stress markers (glutathione and total antioxidant status), and antioxidant enzymes (superoxide dismutase, glutathione peroxidase, and catalase). Results: Low serum levels of folate, B12, and hyperhomocysteinemia were prevalent in patients with T2DM compared with controls. Oxidative stress was evident in patients with T2DM as indicated by low serum levels of glutathione, total antioxidant status, and impaired antioxidant enzymatic activities (superoxide dismutase, glutathione peroxidase, and catalase). Conclusion: The low intake of folate and B12 is associated with low serum levels of these two nutrients and hyperhomocysteinemia in Omani adults with T2DM.
KW - Folate
KW - Homocysteine
KW - Oxidative stress
KW - Type 2 diabetes mellitus
KW - Vitamin B12
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U2 - 10.1016/j.nut.2012.01.005
DO - 10.1016/j.nut.2012.01.005
M3 - Article
C2 - 22595450
AN - SCOPUS:84862208421
SN - 0899-9007
VL - 28
SP - e23-e26
JO - Nutrition
JF - Nutrition
IS - 7-8
ER -
